(+)-Osbeckic acidCAS# 112923-64-5 |
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Number of papers citing our products
| Cas No. | 112923-64-5 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C7H6O6 | M.Wt | 186.12 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Osbeckic acid | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
(+)-Osbeckic acid Dilution Calculator
(+)-Osbeckic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.3729 mL | 26.8644 mL | 53.7288 mL | 107.4576 mL | 134.3219 mL |
| 5 mM | 1.0746 mL | 5.3729 mL | 10.7458 mL | 21.4915 mL | 26.8644 mL |
| 10 mM | 0.5373 mL | 2.6864 mL | 5.3729 mL | 10.7458 mL | 13.4322 mL |
| 50 mM | 0.1075 mL | 0.5373 mL | 1.0746 mL | 2.1492 mL | 2.6864 mL |
| 100 mM | 0.0537 mL | 0.2686 mL | 0.5373 mL | 1.0746 mL | 1.3432 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitory Effects of Phenylpropanoid Derivatives from Oenanthe javanica on Antigen-Stimulated Degranulation in RBL-2H3 Cells.[Pubmed:31125231]
J Nat Prod. 2019 Jun 28;82(6):1518-1526.
Two diacyldaucic acids (1 and 2), an alpha,beta-unsaturated gamma-lactone-type lignan (3) and its derivatives (4-6), and 12 known compounds were isolated from a traditional East Asian vegetable, Oenanthe javanica. The absolute configuration of 1 was validated by obtaining (+)-Osbeckic acid through acid hydrolysis. The absolute configurations of 3-5 were determined by comparing their experimental and computed ECD data. The conclusion was supported by applying the phenylglycine methyl ester method to 3. Compound 6 was obtained as an interconverting mixture of isomers in a 3:1 trans- cis ratio. Several water-soluble components (1, 3, and 6) showed concentration-dependent inhibitory effects on antigen-stimulated degranulation in RBL-2H3 cells without producing any direct cytotoxicity against RBL-2H3 or HeLa cells.
Identification of a new natural vasorelaxatant compound, (+)-osbeckic acid, from rutin-free tartary buckwheat extract.[Pubmed:20873790]
J Agric Food Chem. 2010 Oct 27;58(20):10876-9.
The candidates responsible for vasorelaxation action of rutin-free tartary buckwheat extract (TBSP) were examined in this study. As a result of reversed-phase high-performance liquid chromatography (HPLC) separations, five prominent peaks in the acidic fraction of TBSP were obtained at 260 nm. Among the five collected peaks, we successfully identified four compounds by nuclear magnetic resonance (NMR) and mass spectrometry (MS) measurements: (+)-Osbeckic acid as a dimer ([M - H](-) m/z: 371.2 > 184.9 > 140.9), 5-hydroxymethyl-2-furoic acid, protocatechuic acid, and p-hydroxybenzoic acid. A vascular contractive measurement in 1.0 muM phenylephrine-contracted Sprague-Dawley rat thoracic aorta rings revealed that (+)-Osbeckic acid dimer evoked a potent vasorelaxant effect with an EC50 value of 887 muM compared to other isolates (EC50: 5-hydroxymethyl-2-furoic acid, 3610 muM; protocatechuic acid, 2160 muM; p-hydroxybenzoic acid, no inhibition). Dimeric (+)-Osbeckic acid was stable in solutions and at high temperatures, while its degraded peak on the HPLC chromatogram was observed when it was dissolved in dimethyl sulfoxide.
