PanaxydiolCAS# 708257-91-4 |
- (3R,10S)-Heptadeca-1,8-diene-4,6-diyne-3,10-diol
Catalog No.:BCC9111
CAS No.:63910-76-9
Quality Control & MSDS
3D structure
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| Cas No. | 708257-91-4 | SDF | Download SDF |
| PubChem ID | 71404807 | Appearance | Oil |
| Formula | C17H24O2 | M.Wt | 260.4 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,10S)-heptadeca-1,8-dien-4,6-diyne-3,10-diol | ||
| SMILES | CCCCCCCC(C=CC#CC#CC(C=C)O)O | ||
| Standard InChIKey | DSVMWGREWREVQQ-SJORKVTESA-N | ||
| Standard InChI | InChI=1S/C17H24O2/c1-3-5-6-7-11-14-17(19)15-12-9-8-10-13-16(18)4-2/h4,12,15-19H,2-3,5-7,11,14H2,1H3/t16-,17+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Panaxydiol can inhibit rat liver cholesterol acyltransferase (ACAT) with IC50 values of 45 microM. |
Panaxydiol Dilution Calculator
Panaxydiol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8402 mL | 19.2012 mL | 38.4025 mL | 76.8049 mL | 96.0061 mL |
| 5 mM | 0.768 mL | 3.8402 mL | 7.6805 mL | 15.361 mL | 19.2012 mL |
| 10 mM | 0.384 mL | 1.9201 mL | 3.8402 mL | 7.6805 mL | 9.6006 mL |
| 50 mM | 0.0768 mL | 0.384 mL | 0.768 mL | 1.5361 mL | 1.9201 mL |
| 100 mM | 0.0384 mL | 0.192 mL | 0.384 mL | 0.768 mL | 0.9601 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities.[Pubmed:15796588]
J Agric Food Chem. 2005 Apr 6;53(7):2518-23.
A dichloromethane extract of root celery yielded falcarinol, falcarindiol, Panaxydiol, and the new polyacetylene 8-O-methylfalcarindiol. The structure of the new compound was established by one- and two-dimensional (1D and 2D) NMR, mass spectrometry, and optical rotation data. Nonpolar extracts of roots and bulbs of carrots, celery, fennel, parsley, and parsnip were investigated for their content of polyacetylenes by high-performance liquid chromatography with diode array detection (HPLC-DAD). All five species contained polyacetylenes, although carrots and fennel only in minor amounts. Additionally, the cytotoxicity of the four polyacetylenes against five different cell lines was evaluated by the annexin V-PI assay. Falcarinol proved to be the most active compound with a pronounced toxicity against acute lymphoblastic leukemia cell line CEM-C7H2, with an IC(50) of 3.5 micromol/L. The possible chemopreventive impact of the presented findings is discussed briefly.
Synthesis of panax acetylenes: chiral syntheses of acetylpanaxydol, PQ-3 and panaxydiol.[Pubmed:15056955]
Chem Pharm Bull (Tokyo). 2004 Apr;52(4):418-21.
Acetylpanaxydol (1-Ac), PQ-3 (2) and Panaxydiol (3) and their optical isomers were synthesized from L-(+)-diethyl tartrate. The absolute configurations of 1-Ac, 2 and 3 were determined to be 1-Ac (3R,9R,10S), 2 (9R,10S) and 3 (3R,10S), respectively, by comparisons of their optical rotations and the NMR data of their MTPA esters with those of natural products.
