Penicillin G Sodiumpenicillin antibiotic CAS# 69-57-8 |
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Quality Control & MSDS
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| Cas No. | 69-57-8 | SDF | Download SDF |
| PubChem ID | 23668834 | Appearance | Powder |
| Formula | C16H17N2NaO4S | M.Wt | 356.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (280.61 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | sodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | ||
| SMILES | [Na+].CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C([O-])=O | ||
| Standard InChIKey | FCPVYOBCFFNJFS-LQDWTQKMSA-M | ||
| Standard InChI | InChI=1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Penicillin G Sodium Dilution Calculator
Penicillin G Sodium Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8061 mL | 14.0304 mL | 28.0607 mL | 56.1214 mL | 70.1518 mL |
| 5 mM | 0.5612 mL | 2.8061 mL | 5.6121 mL | 11.2243 mL | 14.0304 mL |
| 10 mM | 0.2806 mL | 1.403 mL | 2.8061 mL | 5.6121 mL | 7.0152 mL |
| 50 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.1224 mL | 1.403 mL |
| 100 mM | 0.0281 mL | 0.1403 mL | 0.2806 mL | 0.5612 mL | 0.7015 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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IC50: 0.002 µg/ml for Streptococcus pneumoniae serotype 4
Penicillin G sodium is a penicillin antibiotic against sensitive organisms during the stage of active multiplication and acts by inhibiting the biosynthesis of bacterial cell wall mucopeptides. It is not active against penicillinase-producing bacteria, which include many strains of staphylococci.
In vitro: Penicillin G sodium works by interfering with the formation of the bacteria's cell wall. This weakens the cell wall and kills the bacteria. Penicillin G is highly effective in-vitro against staphylococci, streptococci and pneumococci. Other organisms sensitive in-vitro to penicillin G are Neisseria gonorrhoeae, Bacillus anthracis, Corynebacterium diphtheriae, Clostridia et al. Treponema pallidum is extremely sensitive [1].
In vivo: With intermittent intramuscular administration of penicillin normal rats were cured after doses of 4 mg/kg/d, whereas decomplemented rats recovered only after daily doses of above 100 mg/kg. When penicillin was administered by way of continuous infusion, doses of 3.5 mg/kg/d were required for a cure of infections in both normal and decomplemented rats [2].
Clinical trials: Penicillin G sodium is used to treat a wide variety of bacterial infections. It is also used to prevent the heart infection in patients with certain heart diseases who are having surgery. Penicillin G sodium is known as a natural penicillin antibiotic. It works by stopping the growth of bacteria [1].
Reference:
[1] Bakker-Woudenberg IA, van den Berg JC, Fontijne P, Michel MF. Efficacy of continuous versus intermittent administration of penicillin G in Streptococcus pneumoniae pneumonia in normal and immunodeficient rats. Eur J Clin Microbiol. 1984 Apr;3(2):131-5.
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Stability of penicillin G sodium diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in polyvinyl chloride bag containers and elastomeric pump containers.[Pubmed:24688042]
Am J Health Syst Pharm. 2014 Apr 15;71(8):669-73.
PURPOSE: The stability of Penicillin G Sodium solutions stored in polyvinyl chloride (PVC) bags or elastomeric pump containers was studied. METHODS: Test samples were prepared by diluting powdered Penicillin G Sodium (10 million units/10-mL vial) to solutions of 2,500 or 50,000 units/mL with 0.9% sodium chloride injection or 5% dextrose injection. The preparations were transferred to 250-mL PVC bags and elastomeric pump containers. All samples were prepared in triplicate and stored at 5 degrees C. Chemical stability was measured by a stability-indicating high-performance liquid chromatographic (HPLC) assay and by pH evaluation. Particulate matter was evaluated according to compendial standards using a light-obscuration particle count test. Preparations were visually examined throughout the study. RESULTS: After 21 days of storage, all test samples remained chemically stable, with an HPLC assay recovery value of more than 90% of the initial value. After 28 days, all samples prepared with either diluent and stored in PVC bags, as well as the samples diluted to 2,500 units/mL with sodium chloride injection and stored in elastomeric pump containers, did not meet the recovery acceptance limit. For all test samples, the mean pH consistently decreased during storage, from about 6.4 to about 5.5. Particle counts remained acceptable throughout the study, and no change in appearance was observed. CONCLUSION: Penicillin G for injection (2,500 and 50,000 units/mL) diluted in 0.9% sodium chloride injection or 5% dextrose injection and stored at 5 degrees C in PVC containers or elastomeric pump containers was physically and chemically stable for a period of at least 21 days.
Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.[Pubmed:27408337]
Can J Vet Res. 2016 Jul;80(3):230-5.
The aim of this study was to determine the pharmacokinetics of amikacin and Penicillin G Sodium when administered in combination as an intravenous regional limb perfusion (IVRLP) to horses. Seven healthy adult horses underwent an IVRLP in the cephalic vein with 2 g of amikacin sulfate and 10 mill IU of Penicillin G Sodium diluted to 60 mL in 0.9% saline. A pneumatic tourniquet set at 450 mmHg was left in place for 30 min. Synovial fluid was collected from the metacarpophalangeal joint 35 min and 2, 6, 12, and 24 h after infusion of the antimicrobials. Concentrations of amikacin and penicillin in synovial fluid were quantitated by liquid chromatography tandem-mass spectrometry analysis. Therapeutic concentrations of amikacin and penicillin for equine-susceptible pathogens were achieved in the synovial fluid. Maximum synovial concentrations (Cmax) (mean +/- SE) for amikacin and penicillin were 132 +/- 33 mug/mL and 8474 +/- 5710 ng/mL, respectively. Only 3 horses had detectable levels of penicillin at 6 h and 1 at the 12 h sample. The combination of amikacin with Penicillin G Sodium via IVDLP resulted in reported therapeutic concentrations of both antibiotics in the synovial fluid. The Cmax:MIC (minimum inhibitory concentration) ratio for amikacin was 8:1 and Time > MIC for penicillin was 6 h. At 24 h, the mean concentration of amikacin was still above 4 mug/mL. Terminal elimination rate constants (T1/2 lambdaz) were 13.6 h and 2.8 h for amikacin and penicillin, respectively. The use of IVDLP with penicillin may therefore not be practical as rapid clearance of penicillin from the synovial fluid requires frequent perfusions to maintain acceptable therapeutic concentrations.
Electrical conductances of dilute aqueous solutions of sodium penicillin G, potassium penicillin G, and potassium penicillin V in the 278.15-313.15 K temperature range.[Pubmed:17887789]
J Phys Chem B. 2007 Oct 18;111(41):11957-67.
Systematic determinations of electrical conductivities of sodium penicillin G, potassium penicillin G, and potassium penicillin V in the 278.15-313.15 K temperature range are reported. These conductivities are examined by applying the Quint-Viallard conductivity equations and the Debye-Huckel equations for activity coefficients. Determined dissociation constants and the limiting conductances of penicillin anions are based on the assumption that in dilute aqueous solutions, penicillin salts behave as acidic salts of dibasic acids, which are the final products of degradation reactions in acidic media.
Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis.[Pubmed:12802748]
Clin Infect Dis. 2003 Jun 15;36(12):1507-13.
A prospective, open-label, randomized trial at Khon Kaen Hospital (Thailand) was conducted from July 2000 through December 2001 to compare the clinical efficacies of ceftriaxone and sodium penicillin G for the treatment of severe leptospirosis. A total of 173 patients with severe leptospirosis were randomly assigned to be treated with either intravenous ceftriaxone (1 g daily for 7 days; n=87) or intravenous sodium penicillin G (1.5 million U every 6 h for 7 days; n=86). The primary outcome was time to fever resolution. Survival analysis demonstrated that the median duration of fever was 3 days for both groups. Ten patients (5 in each group) died of leptospirosis infection. There were no statistically significant differences in the duration of organ dysfunction. Ceftriaxone and sodium penicillin G were equally effective for the treatment of severe leptospirosis. Once-daily administration and the extended spectrum of ceftriaxone against bacteria provide additional benefits over intravenous penicillin.
