H-D-Glu-OHEndogenous, non-selective agonist. Less active enantiomer CAS# 6893-26-1 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 6893-26-1 | SDF | Download SDF |
| PubChem ID | 23327 | Appearance | Powder |
| Formula | C5H9NO4 | M.Wt | 147.1 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (R)-Glutamic acid | ||
| Solubility | H2O : 6 mg/mL (40.78 mM; Need ultrasonic) | ||
| Chemical Name | (2R)-2-aminopentanedioic acid | ||
| SMILES | C(CC(=O)O)C(C(=O)O)N | ||
| Standard InChIKey | WHUUTDBJXJRKMK-GSVOUGTGSA-N | ||
| Standard InChI | InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Excitatory amino acid acting at NMDA receptors; less active than the L-isomer,L-glutamic acid. |
H-D-Glu-OH Dilution Calculator
H-D-Glu-OH Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.7981 mL | 33.9905 mL | 67.981 mL | 135.9619 mL | 169.9524 mL |
| 5 mM | 1.3596 mL | 6.7981 mL | 13.5962 mL | 27.1924 mL | 33.9905 mL |
| 10 mM | 0.6798 mL | 3.399 mL | 6.7981 mL | 13.5962 mL | 16.9952 mL |
| 50 mM | 0.136 mL | 0.6798 mL | 1.3596 mL | 2.7192 mL | 3.399 mL |
| 100 mM | 0.068 mL | 0.3399 mL | 0.6798 mL | 1.3596 mL | 1.6995 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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H-D-Glu-OH
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Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes.[Pubmed:2901691]
Neuroscience. 1988 Jul;26(1):17-31.
Structure/activity relations of agonists and antagonists for the N-methyl-D-aspartate receptor have been investigated by measuring the ability of a large range of substances to inhibit binding of [3H]2-amino-5-phosphonopentanoate to rat brain membranes. A major difference between optimum structures for agonist and antagonist activity lay in the differential effectiveness of sulphonic and phosphonic acid groups as the omega-acidic terminal in these two types of compound. The sulphonic acid moiety was an effective omega-acidic terminal in short chain agonists, but not in longer chain antagonists, while the phosphonic acid group was the most effective omega-acidic terminal in longer chain antagonists, but was only very weakly active in short chain agonists. It is proposed that the binding site of the omega-acidic terminal of antagonists is different from that for the omega-acidic group of agonists. Other structural features conducive to effective interaction of ligands with the receptor are discussed.
D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
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