Home >> Research Area >>Microbiology and Virology>>NA>> Peramivir Trihydrate

Peramivir Trihydrate

CAS# 1041434-82-5

Peramivir Trihydrate

Catalog No. BCC4956----Order now to get a substantial discount!

Product Name & Size Price Stock
Peramivir Trihydrate: 5mg $138 In Stock
Peramivir Trihydrate: 10mg Please Inquire In Stock
Peramivir Trihydrate: 20mg Please Inquire Please Inquire
Peramivir Trihydrate: 50mg Please Inquire Please Inquire
Peramivir Trihydrate: 100mg Please Inquire Please Inquire
Peramivir Trihydrate: 200mg Please Inquire Please Inquire
Peramivir Trihydrate: 500mg Please Inquire Please Inquire
Peramivir Trihydrate: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Peramivir Trihydrate

Number of papers citing our products

Chemical structure

Peramivir Trihydrate

3D structure

Chemical Properties of Peramivir Trihydrate

Cas No. 1041434-82-5 SDF Download SDF
PubChem ID 11954371 Appearance Powder
Formula C15H34N4O7 M.Wt 382.45
Type of Compound N/A Storage Desiccate at -20°C
Synonyms RWJ 270201 trihydrate; BCX 1812 trihydrate
Solubility H2O : 6.6 mg/mL (17.26 mM; Need ultrasonic)
Chemical Name (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate
SMILES CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O
Standard InChIKey RFUCJKFZFXNIGB-ZBBHRWOZSA-N
Standard InChI InChI=1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Peramivir Trihydrate

DescriptionPeramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. IC50 Value: 0.09 nM Target: Neuraminidase Peramivir is an experimental antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. It has been authorized for the emergency use of treatment of certain hospitalized patients with known or suspected 2009 H1N1 influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. From Wikipedia

References:
[1]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM. Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09. PLoS One. 2012;7(6):e40261. [2]. Sakata H. Clinical efficiency in children treated with intravenous drip infusion of peramivirJpn J Antibiot. 2011 Dec;64(6):383-7. [3]. Abed Y, Pizzorno A, Boivin G. Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation. Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80. [4]. Shobugawa Y, Saito R, Sato I, Kawashima T, Dapat C, Dapat IC, Kondo H, Suzuki Y, Saito K, Suzuki H. Clinical effectiveness of neuraminidase inhibitors-oseltamivir, zanamivir, laninamivir, and peramivir-for treatment of influenza A(H3N2) and A(H1N1)pdm09 [5]. Yu Y, Garg S, Yu PA, Kim HJ, Patel A, Merlin T, Redd S, Uyeki TM. Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under emergency use authorization, October 2009-June 2010. Clin Infect Dis. 2012 Jul;55(1):8-15.

Peramivir Trihydrate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Peramivir Trihydrate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Peramivir Trihydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6147 mL 13.0736 mL 26.1472 mL 52.2944 mL 65.368 mL
5 mM 0.5229 mL 2.6147 mL 5.2294 mL 10.4589 mL 13.0736 mL
10 mM 0.2615 mL 1.3074 mL 2.6147 mL 5.2294 mL 6.5368 mL
50 mM 0.0523 mL 0.2615 mL 0.5229 mL 1.0459 mL 1.3074 mL
100 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.5229 mL 0.6537 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Peramivir Trihydrate

Peramivir (RWJ 270201; Rapiacta; BCX 1812) is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.

Featured Products
New Products
 

Description

Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes.

Keywords:

Peramivir Trihydrate,1041434-82-5,RWJ 270201 trihydrate; BCX 1812 trihydrate,Natural Products,NA, buy Peramivir Trihydrate , Peramivir Trihydrate supplier , purchase Peramivir Trihydrate , Peramivir Trihydrate cost , Peramivir Trihydrate manufacturer , order Peramivir Trihydrate , high purity Peramivir Trihydrate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: