PicralinalCAS# 20045-06-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 20045-06-1 | SDF | Download SDF |
| PubChem ID | 46229103 | Appearance | Powder |
| Formula | C21H22N2O4 | M.Wt | 366.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | methyl (1R,9S,11S,14E,15S,17S,19R)-14-ethylidene-19-formyl-18-oxa-2,12-diazahexacyclo[9.6.1.19,15.01,9.03,8.012,17]nonadeca-3,5,7-triene-19-carboxylate | ||
| SMILES | CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)(C=O)C(=O)OC | ||
| Standard InChIKey | RHBAENOZUZWALZ-GGZNVOGHSA-N | ||
| Standard InChI | InChI=1S/C21H22N2O4/c1-3-12-10-23-16-8-14(12)19(11-24,18(25)26-2)20-9-17(23)27-21(16,20)22-15-7-5-4-6-13(15)20/h3-7,11,14,16-17,22H,8-10H2,1-2H3/b12-3-/t14-,16-,17-,19-,20-,21-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Picralinal has anti-inflammatory and analgesic effects. |
| Targets | COX | LOX |
Picralinal Dilution Calculator
Picralinal Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7293 mL | 13.6463 mL | 27.2926 mL | 54.5852 mL | 68.2314 mL |
| 5 mM | 0.5459 mL | 2.7293 mL | 5.4585 mL | 10.917 mL | 13.6463 mL |
| 10 mM | 0.2729 mL | 1.3646 mL | 2.7293 mL | 5.4585 mL | 6.8231 mL |
| 50 mM | 0.0546 mL | 0.2729 mL | 0.5459 mL | 1.0917 mL | 1.3646 mL |
| 100 mM | 0.0273 mL | 0.1365 mL | 0.2729 mL | 0.5459 mL | 0.6823 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- UB 165 fumarate
Catalog No.:BCC5746
CAS No.:200432-86-6
- 6-Chloroguanine riboside
Catalog No.:BCC8771
CAS No.:2004-07-1
- Fmoc-D-Cys(Trt)-OPfp
Catalog No.:BCC3482
CAS No.:200395-72-8
- Fmoc-D-Cit-OH
Catalog No.:BCC3181
CAS No.:200344-33-8
- Fmoc-D-Asp(OtBu)-Opfp
Catalog No.:BCC3472
CAS No.:200335-75-7
- Boc-D-Asp(OtBu)-OH.DCHA
Catalog No.:BCC3373
CAS No.:200334-95-8
- Melanocyte stimulating hormone release inhibiting factor
Catalog No.:BCC1043
CAS No.:2002-44-0
- Z-Arg(Pbf)-OH.CHA
Catalog No.:BCC3064
CAS No.:200190-89-2
- CGP 3466B maleate
Catalog No.:BCC5955
CAS No.:200189-97-5
- Fmoc-Arg(Pbf)-OPfp
Catalog No.:BCC3041
CAS No.:200132-16-7
- Dehydrochromolaenin
Catalog No.:BCN4072
CAS No.:20013-76-7
- Pyrocurzerenone
Catalog No.:BCN4067
CAS No.:20013-75-6
- GMX1778 (CHS828)
Catalog No.:BCC6527
CAS No.:200484-11-3
- Hotrienol
Catalog No.:BCN6340
CAS No.:20053-88-7
- Fmoc-D-Glu(OtBu)-OPfp
Catalog No.:BCC3497
CAS No.:200616-21-3
- Fmoc-N-Me-Glu(OtBu)-OH
Catalog No.:BCC3213
CAS No.:200616-40-6
- Fmoc-D-Gln-OPfp
Catalog No.:BCC3487
CAS No.:200622-33-9
- Fmoc-D-Gln(Trt)-OH
Catalog No.:BCC3488
CAS No.:200623-62-7
- Hennadiol
Catalog No.:BCN4679
CAS No.:20065-99-0
- Piplartine
Catalog No.:BCN4037
CAS No.:20069-09-4
- (-)-Phyllocladene
Catalog No.:BCN7661
CAS No.:20070-61-5
- 7-Hydroxy-PIPAT maleate
Catalog No.:BCC6760
CAS No.:200722-46-9
- 16-Nor-15-oxodehydroabietic acid
Catalog No.:BCN3943
CAS No.:200813-31-6
- Pseudoneolinderane
Catalog No.:BCN8034
CAS No.:20082-45-5
Pharmacological evaluation of Alstonia scholaris: anti-inflammatory and analgesic effects.[Pubmed:20219658]
J Ethnopharmacol. 2010 May 27;129(2):174-81.
ETHNOPHARMACOLOGICAL RELEVANCE: Alstonia scholaris (Apocynaceae) has been historically used in "dai" ethnopharmacy to treat chronic respiratory diseases. The leaf extract, developed as a commercially available traditional Chinese medicine, used to release tracheitis and cold symptom, has also been prescribed in hospitals and sold over the counter in drug stores. AIM OF THE STUDY: The investigation evaluated the anti-inflammatory and analgesic activities of the ethanolic extract, fractions and main alkaloids of Alstonia scholaris leaf to provide experimental evidence for its traditional and modern clinical use. Besides, to discover the active fraction and components for further better use in Chinese medicine is hopeful. MATERIALS AND METHODS: The leaf of Alstonia scholaris was extracted with ethanol and then separated into different fractions. Furthermore, alkaloids were isolated by phytochemical method. The analgesic activities were investigated using acetic acid-induced writhing, hot-plate and formalin tests in mice. The anti-inflammatory activities were carried out in vivo and in vitro, including xylene-induced ear edema and carrageenan-induced air pouch formation in mice, and COX-1, -2 and 5-LOX inhibition. RESULTS: It has been exhibited that the EtOAc and alkaloid fractions reduced acetic acid-induced writhing response in mice, significantly. The ethanolic extract, EtOAc and alkaloid fractions remarkably inhibited xylene-induced ear edema. Further investigation was focused on the alkaloids fraction and three main alkaloids isolated from the alkaloids fraction, in different animal models. Alkaloids reduced acetic acid-induced writhing response, and xylene-induced ear edema in mice. In the hot-plate test, alkaloids did not increase the latency period of mice obviously. In the formalin test, alkaloids did not inhibit the licking time in first phase, but significantly inhibited the licking time in second phase of mice. Alkaloids increased significantly SOD activity and decreased levels of NO, PGE2 and MDA significantly, in air pouch mice model. Moreover, some alkaloids isolated from the leaf of Alstonia scholaris exhibited inhibition of COX-1, COX-2 and 5-LOX in vitro anti-inflammatory assay, which supported alkaloids as the bioactive fraction. CONCLUSIONS: The alkaloids fraction of Alstonia scholaris leaf, three main alkaloids, picrinine, vallesamine and scholaricine, may produce the anti-inflammatory and analgesic effect peripherally based on several in vivo assays. In in vitro tests, alkaloids exhibited inhibition of inflammatory mediators (COX-1, COX-2 and 5-LOX), which is accordant with results on animal models. Besides, COX-2/5-LOX dual inhibitors found in the experiment, such as 16-formyl-5alpha-methoxystrictamine, Picralinal, and tubotaiwine might be valuable for further attention.
