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Podophyllotoxin 4-O-glucoside

CAS# 16481-54-2

Podophyllotoxin 4-O-glucoside

Catalog No. BCN8064----Order now to get a substantial discount!

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Podophyllotoxin 4-O-glucoside: 5mg $132 In Stock
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Quality Control of Podophyllotoxin 4-O-glucoside

Number of papers citing our products

Chemical structure

Podophyllotoxin 4-O-glucoside

3D structure

Chemical Properties of Podophyllotoxin 4-O-glucoside

Cas No. 16481-54-2 SDF Download SDF
PubChem ID 161177 Appearance Powder
Formula C28H32O13 M.Wt 576.55
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (5R,5aR,8aR,9R)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
SMILES COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)OC6C(C(C(C(O6)CO)O)O)O
Standard InChIKey NXVJTGLCCSFGAT-QNDDJFOYSA-N
Standard InChI InChI=1S/C28H32O13/c1-34-17-4-11(5-18(35-2)26(17)36-3)20-12-6-15-16(39-10-38-15)7-13(12)25(14-9-37-27(33)21(14)20)41-28-24(32)23(31)22(30)19(8-29)40-28/h4-7,14,19-25,28-32H,8-10H2,1-3H3/t14-,19+,20+,21-,22+,23-,24+,25-,28-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Podophyllotoxin 4-O-glucoside

The herbs of Dysosma versipellis

Biological Activity of Podophyllotoxin 4-O-glucoside

TargetsTNF-α | NF-kB | IL Receptor

Podophyllotoxin 4-O-glucoside Dilution Calculator

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Podophyllotoxin 4-O-glucoside Molarity Calculator

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Preparing Stock Solutions of Podophyllotoxin 4-O-glucoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7345 mL 8.6723 mL 17.3445 mL 34.6891 mL 43.3614 mL
5 mM 0.3469 mL 1.7345 mL 3.4689 mL 6.9378 mL 8.6723 mL
10 mM 0.1734 mL 0.8672 mL 1.7345 mL 3.4689 mL 4.3361 mL
50 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6938 mL 0.8672 mL
100 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.3469 mL 0.4336 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Podophyllotoxin 4-O-glucoside

Production of tumour-inhibitory lignans in callus cultures of Podophyllum hexandrum.[Pubmed:24227060]

Plant Cell Rep. 1990 Nov;9(7):382-5.

Callus cultures have been established from root explants of aseptically-grown Podophyllum hexandrum seedlings. A fully defined medium based on Gamborg's B5 salts supplemented with 2/4-dichlorophenoxyacetic acid, gibberellic acid and 6-benzylaminopurine was effective for both initiation and sustained growth of callus tissue. Cultures produced anticancer lignans podophyllotoxin, 4'-demethylpodophyllotoxin and Podophyllotoxin 4-O-glucoside at levels similar to those found in the expiant material as assayed by high performance liquid chromatography. The relative proportions of podophyllotoxin and 4'-demethyl-podophyllotoxin were markedly influenced by the presence of plant growth regulators. Particularly high levels of podophyllotoxin were associated with growth regulator induced tissue differentiation.

Podophyllotoxin lignans enhance IL-1beta but suppress TNF-alpha mRNA expression in LPS-treated monocytes.[Pubmed:11322652]

Immunopharmacol Immunotoxicol. 2001 Feb;23(1):83-95.

There exists a growing body of research which indicates that antimitotics such as taxol and colchicine influence cytokine gene expression. In the present study we examined the effect of podophyllotoxin and six analogs on nuclear factor kappa B (NF-kappa B) activation, and on interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) mRNA expression in human THP-1 monocytes. All compounds were inactive between 0.001microM and 10microM when tested alone. However, podophyllotoxin (0.1 microM) enhanced LPS-induced NF-kappa B activation and IL-1beta mRNA expression between 2 and 3-fold. In contrast, LPS-induced TNF-alpha mRNA expression was decreased between 3 and 6-fold. Comparable results were also observed with the three analogs acetylpodophyllotoxin, 4'-demethylpodophyllotoxin and alpha-peltatin. The remaining three analogs (podophyllotoxin-4-O-glucoside, beta-peltatin-beta-D-glucopyransoide and 1,2,3,4-dehydrodesoxypodophyllotoxin) were inactive. Clearly certain structural features such as the presence of a glycosidic group or ring aromatization results in loss of biological activity. Interestingly, the analogs that were inactive in our assays have also been previously shown to lack affinity for tubulin binding. These results suggest that during the initial hours of exposure to podophyllotoxin or specific analogs these compounds do not act as independent stimulants of human monocyte activation, but can selectively enhance or suppress LPS-induced cytokine gene expression.

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