Pseurotin A

CAS# 58523-30-1

Pseurotin A

Catalog No. BCN7246----Order now to get a substantial discount!

Product Name & Size Price Stock
Pseurotin A: 5mg $828 In Stock
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Quality Control of Pseurotin A

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Chemical structure

Pseurotin A

3D structure

Chemical Properties of Pseurotin A

Cas No. 58523-30-1 SDF Download SDF
PubChem ID 5477694 Appearance Powder
Formula C22H25NO8 M.Wt 431.44
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 8-benzoyl-2-[(E)-1,2-dihydroxyhex-3-enyl]-9-hydroxy-8-methoxy-3-methyl-1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione
SMILES CCC=CC(C(C1=C(C(=O)C2(O1)C(C(NC2=O)(C(=O)C3=CC=CC=C3)OC)O)C)O)O
Standard InChIKey SLYDIPAXCVVRNY-VZUCSPMQSA-N
Standard InChI InChI=1S/C22H25NO8/c1-4-5-11-14(24)15(25)16-12(2)17(26)21(31-16)19(28)22(30-3,23-20(21)29)18(27)13-9-7-6-8-10-13/h5-11,14-15,19,24-25,28H,4H2,1-3H3,(H,23,29)/b11-5+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pseurotin A

The cultures of marine Bacillus sp. FS8D.

Biological Activity of Pseurotin A

Description1. Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro. 2. Pseurotin A shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively. 3. Pseurotin A shows to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 uM, the targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A.
TargetsAntifection | Immunology & Inflammation related

Pseurotin A Dilution Calculator

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Pseurotin A Molarity Calculator

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Preparing Stock Solutions of Pseurotin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3178 mL 11.5891 mL 23.1782 mL 46.3564 mL 57.9455 mL
5 mM 0.4636 mL 2.3178 mL 4.6356 mL 9.2713 mL 11.5891 mL
10 mM 0.2318 mL 1.1589 mL 2.3178 mL 4.6356 mL 5.7945 mL
50 mM 0.0464 mL 0.2318 mL 0.4636 mL 0.9271 mL 1.1589 mL
100 mM 0.0232 mL 0.1159 mL 0.2318 mL 0.4636 mL 0.5795 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pseurotin A

Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.[Pubmed:19179074]

Bioorg Med Chem Lett. 2009 Mar 1;19(5):1457-60.

A natural product, Pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of Pseurotin A was performed. Structure-activity relationship studies of Pseurotin Analogues elucidated that 10-deoxyPseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.

Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii.[Pubmed:18669024]

Z Naturforsch C. 2008 May-Jun;63(5-6):383-8.

Penicillium janczewskii K. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina. When grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. The compounds were for the first time isolated from this species and identified by spectroscopic methods as Pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic peptides by endophytic fungi from Chilean gymnosperms. Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively.

Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.[Pubmed:28641457]

Nat Prod Res. 2018 Jun;32(11):1353-1356.

Pseurotin A was isolated from a culture of marine Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 muM. It has been found that Pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation. The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of Pseurotin A.

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