RA VIICAS# 86229-97-2 |
Quality Control & MSDS
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| Cas No. | 86229-97-2 | SDF | Download SDF |
| PubChem ID | 3034401 | Appearance | Powder |
| Formula | C41H50N6O9 | M.Wt | 770.9 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C2CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC(C(=O)N1)N(C2=O)C)OC)C)C)CC5=CC=C(C=C5)OC)C)C | ||
| Standard InChIKey | MBQKTLYFUYNAPZ-FEZMQHRXSA-N | ||
| Standard InChI | InChI=1S/C41H50N6O9/c1-23-36(48)43-24(2)39(51)45(4)31(19-26-9-14-29(54-7)15-10-26)38(50)44-25(3)40(52)47(6)33-20-27-11-16-30(17-12-27)56-35-22-28(13-18-34(35)55-8)21-32(37(49)42-23)46(5)41(33)53/h9-18,22-25,31-33H,19-21H2,1-8H3,(H,42,49)(H,43,48)(H,44,50)/t23-,24+,25+,31+,32+,33+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Rubia cordifolia
| Description | 1. RA VII is an antitumour agent, shows cytotoxic activity against P-388 cells. 2. RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest. |
RA VII Dilution Calculator
RA VII Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2972 mL | 6.4859 mL | 12.9719 mL | 25.9437 mL | 32.4296 mL |
| 5 mM | 0.2594 mL | 1.2972 mL | 2.5944 mL | 5.1887 mL | 6.4859 mL |
| 10 mM | 0.1297 mL | 0.6486 mL | 1.2972 mL | 2.5944 mL | 3.243 mL |
| 50 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.5189 mL | 0.6486 mL |
| 100 mM | 0.013 mL | 0.0649 mL | 0.1297 mL | 0.2594 mL | 0.3243 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed:24268554]
Bioorg Med Chem Lett. 2013 Dec 15;23(24):6728-31.
An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized. The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC . HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1).
Synthesis of [Tyr-5-Psi(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed:22460024]
Bioorg Med Chem Lett. 2012 Apr 15;22(8):2757-9.
A reduced peptide bond analogue of RA-VII, [Tyr-5-Psi(CH(2)NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with FDPP under dilute conditions gave 3. Analogue 3 showed cytotoxic activity against P-388 cells, but its activity was much weaker than that of parent peptide RA-VII.
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