RA VII

CAS# 86229-97-2

RA VII

Catalog No. BCN3512----Order now to get a substantial discount!

Product Name & Size Price Stock
RA VII: 5mg Please Inquire In Stock
RA VII: 10mg Please Inquire In Stock
RA VII: 20mg Please Inquire Please Inquire
RA VII: 50mg Please Inquire Please Inquire
RA VII: 100mg Please Inquire Please Inquire
RA VII: 200mg Please Inquire Please Inquire
RA VII: 500mg Please Inquire Please Inquire
RA VII: 1000mg Please Inquire Please Inquire

Quality Control of RA VII

Number of papers citing our products

Chemical structure

RA VII

3D structure

Chemical Properties of RA VII

Cas No. 86229-97-2 SDF Download SDF
PubChem ID 3034401 Appearance Powder
Formula C41H50N6O9 M.Wt 770.9
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C2CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC(C(=O)N1)N(C2=O)C)OC)C)C)CC5=CC=C(C=C5)OC)C)C
Standard InChIKey MBQKTLYFUYNAPZ-FEZMQHRXSA-N
Standard InChI InChI=1S/C41H50N6O9/c1-23-36(48)43-24(2)39(51)45(4)31(19-26-9-14-29(54-7)15-10-26)38(50)44-25(3)40(52)47(6)33-20-27-11-16-30(17-12-27)56-35-22-28(13-18-34(35)55-8)21-32(37(49)42-23)46(5)41(33)53/h9-18,22-25,31-33H,19-21H2,1-8H3,(H,42,49)(H,43,48)(H,44,50)/t23-,24+,25+,31+,32+,33+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of RA VII

The roots of Rubia cordifolia

Biological Activity of RA VII

Description1. RA VII is an antitumour agent, shows cytotoxic activity against P-388 cells. 2. RA VII causes the conformational change of F-actin and the stabilization of actin filaments to induce G2 arrest.

RA VII Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

RA VII Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of RA VII

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2972 mL 6.4859 mL 12.9719 mL 25.9437 mL 32.4296 mL
5 mM 0.2594 mL 1.2972 mL 2.5944 mL 5.1887 mL 6.4859 mL
10 mM 0.1297 mL 0.6486 mL 1.2972 mL 2.5944 mL 3.243 mL
50 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.5189 mL 0.6486 mL
100 mM 0.013 mL 0.0649 mL 0.1297 mL 0.2594 mL 0.3243 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on RA VII

Aza-cycloisodityrosine analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed:24268554]

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6728-31.

An aza-cycloisodityrosine analogue of RA-VII, 3, was designed and synthesized. The key aza-cycloisodityrosine unit was prepared by copper(II)-acetate-mediated intramolecular phenylamine/arylboronic acid coupling of dipeptide followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with EDC . HCl and HOOBt under dilute conditions gave 3. Analogue 3 showed significant cytotoxic activity against human promyelocytic leukemia HL-60 cells and human colon carcinoma HCT-116 cells, but its activity was weaker than that of parent peptide RA-VII (1).

Synthesis of [Tyr-5-Psi(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.[Pubmed:22460024]

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2757-9.

A reduced peptide bond analogue of RA-VII, [Tyr-5-Psi(CH(2)NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with FDPP under dilute conditions gave 3. Analogue 3 showed cytotoxic activity against P-388 cells, but its activity was much weaker than that of parent peptide RA-VII.

Keywords:

RA VII,86229-97-2,Natural Products, buy RA VII , RA VII supplier , purchase RA VII , RA VII cost , RA VII manufacturer , order RA VII , high purity RA VII

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: