Roburic acid

CAS# 6812-81-3

Roburic acid

Catalog No. BCN5385----Order now to get a substantial discount!

Product Name & Size Price Stock
Roburic acid: 5mg $40 In Stock
Roburic acid: 10mg Please Inquire In Stock
Roburic acid: 20mg Please Inquire Please Inquire
Roburic acid: 50mg Please Inquire Please Inquire
Roburic acid: 100mg Please Inquire Please Inquire
Roburic acid: 200mg Please Inquire Please Inquire
Roburic acid: 500mg Please Inquire Please Inquire
Roburic acid: 1000mg Please Inquire Please Inquire

Quality Control of Roburic acid

Number of papers citing our products

Chemical structure

Roburic acid

3D structure

Chemical Properties of Roburic acid

Cas No. 6812-81-3 SDF Download SDF
PubChem ID 12315005 Appearance White powder
Formula C30H48O2 M.Wt 440.71
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in chloroform
Chemical Name 3-[(1S,2S,4aR,4bS,6aR,9R,10S,10aR,12aR)-1,4a,4b,6a,9,10-hexamethyl-2-prop-1-en-2-yl-2,3,4,5,6,7,8,9,10,10a,12,12a-dodecahydrochrysen-1-yl]propanoic acid
SMILES CC1CCC2(CCC3(C(=CCC4C3(CCC(C4(C)CCC(=O)O)C(=C)C)C)C2C1C)C)C
Standard InChIKey RPPYCVULPFKBOG-CSHKLQQTSA-N
Standard InChI InChI=1S/C30H48O2/c1-19(2)22-12-16-30(8)24(28(22,6)15-13-25(31)32)10-9-23-26-21(4)20(3)11-14-27(26,5)17-18-29(23,30)7/h9,20-22,24,26H,1,10-18H2,2-8H3,(H,31,32)/t20-,21+,22+,24-,26+,27-,28+,29-,30-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Roburic acid

The roots of Gentiana macrophylla

Biological Activity of Roburic acid

DescriptionRoburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
TargetsCOX
In vitro

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.[Pubmed: 20188172]

Pharmacol Res. 2010 Jun;61(6):519-24.


METHODS AND RESULTS:
Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC(50)). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC(50) values of approximately 10 microM. Senkyunolide O and cryptotanshinone were COX-2 selective inhibitors with IC(50) values of 5 microM and 22 microM, respectively.
CONCLUSIONS:
Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC(50) values of most of these natural product ligands have not been reported previously.

Protocol of Roburic acid

Structure Identification
Zhongguo Zhong Yao Za Zhi. 2005 Oct;30(19):1519-22.

Studies on the chemical constituents in root of Gentiana macrophylla from Shaanxi[Pubmed: 16335823]

To in vestigate the constituents in root of Gentiana macrophylla.
METHODS AND RESULTS:
Various column chromatographic techniques were used for isolation and purification of the principles. The structures were elucidated on the basis of spectral data (UV, IR, MS, 1H-, 13C-NMR etc.) and identified by comparing with standard substance. Eight compounds were identified. Four compounds isolated from the chloroform fraction are: 5-carboxyl-3,4-dihydrogen-1H-2-benzopyran-1-one (1), erythrocentauric acid (2), Roburic acid (3), oleanolic acid (4). Water fraction gave four known secoiridoid glucosides. They were: gentiopicroside (5), swertiamarine (6), sweroside (7), 6'-O-beta-D-glucosylgentiopicroside (8).
CONCLUSIONS:
1 is a novel compound. It was named as erythrocentauric acid. 2 was isolated from genus Gentiana and 8 was isolated from G. macrophylla for the first time.

Roburic acid Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Roburic acid Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Roburic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2691 mL 11.3453 mL 22.6907 mL 45.3813 mL 56.7266 mL
5 mM 0.4538 mL 2.2691 mL 4.5381 mL 9.0763 mL 11.3453 mL
10 mM 0.2269 mL 1.1345 mL 2.2691 mL 4.5381 mL 5.6727 mL
50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1345 mL
100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Roburic acid

Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.[Pubmed:20188172]

Pharmacol Res. 2010 Jun;61(6):519-24.

Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC(50)). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC(50) values of approximately 10 microM. Senkyunolide O and cryptotanshinone were COX-2 selective inhibitors with IC(50) values of 5 microM and 22 microM, respectively. Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC(50) values of most of these natural product ligands have not been reported previously.

[Studies on the chemical constituents in root of Gentiana macrophylla from Shaanxi].[Pubmed:16335823]

Zhongguo Zhong Yao Za Zhi. 2005 Oct;30(19):1519-22.

OBJECTIVE: To in vestigate the constituents in root of Gentiana macrophylla. METHOD: Various column chromatographic techniques were used for isolation and purification of the principles. The structures were elucidated on the basis of spectral data (UV, IR, MS, 1H-, 13C-NMR etc.) and identified by comparing with standard substance. RESULT: Eight compounds were identified. Four compounds isolated from the chloroform fraction are: 5-carboxyl-3,4-dihydrogen-1H-2-benzopyran-1-one (1), erythrocentauric acid (2), Roburic acid (3), oleanolic acid (4). Water fraction gave four known secoiridoid glucosides. They were: gentiopicroside (5), swertiamarine (6), sweroside (7), 6'-O-beta-D-glucosylgentiopicroside (8). CONCLUSION: 1 is a novel compound. It was named as erythrocentauric acid. 2 was isolated from genus Gentiana and 8 was isolated from G. macrophylla for the first time.

Description

Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC50s of 5 and 9 μM for COX-1 and COX-2, respectively.

Keywords:

Roburic acid,6812-81-3,Natural Products, buy Roburic acid , Roburic acid supplier , purchase Roburic acid , Roburic acid cost , Roburic acid manufacturer , order Roburic acid , high purity Roburic acid

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: