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Chonglou Saponin VII

CAS# 68124-04-9

Chonglou Saponin VII

Catalog No. BCN4239----Order now to get a substantial discount!

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Quality Control of Chonglou Saponin VII

Number of papers citing our products

Chemical structure

Chonglou Saponin VII

3D structure

Chemical Properties of Chonglou Saponin VII

Cas No. 68124-04-9 SDF Download SDF
PubChem ID 176233 Appearance White powder
Formula C51H82O21 M.Wt 1031.2
Type of Compound Steroids Storage Desiccate at -20°C
Synonyms Chonglouoside VII; Dioscinin; 17-Hydroxyparis II; Paris saponin VII; Pennogenin 3-O-rhamnosylchacotrioside; Saponin Tg
Solubility Soluble in methanol; sparingly soluble in water
SMILES CC1CCC2(C(C3(C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)OC9C(C(C(C(O9)C)O)O)O)O)O)O)OC2C(C(C(C(O2)C)O)O)O)C)C)O)C)OC1
Standard InChIKey FBFJAXUYHGSVFN-IYUYFXHASA-N
Standard InChI InChI=1S/C51H82O21/c1-20-10-15-50(63-19-20)24(5)51(62)31(72-50)17-29-27-9-8-25-16-26(11-13-48(25,6)28(27)12-14-49(29,51)7)67-47-43(71-45-38(59)35(56)33(54)22(3)65-45)40(61)42(30(18-52)68-47)70-46-39(60)36(57)41(23(4)66-46)69-44-37(58)34(55)32(53)21(2)64-44/h8,20-24,26-47,52-62H,9-19H2,1-7H3/t20-,21+,22+,23+,24-,26+,27-,28+,29+,30-,31+,32+,33+,34-,35-,36+,37-,38-,39-,40+,41+,42-,43-,44+,45+,46+,47-,48+,49+,50-,51-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chonglou Saponin VII

The roots of Paris polyphylla

Biological Activity of Chonglou Saponin VII

Description1. Chonglou saponin VII shows inhibitory effects on cell proliferation.

Chonglou Saponin VII Dilution Calculator

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Chonglou Saponin VII Molarity Calculator

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Preparing Stock Solutions of Chonglou Saponin VII

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.9697 mL 4.8487 mL 9.6974 mL 19.3949 mL 24.2436 mL
5 mM 0.1939 mL 0.9697 mL 1.9395 mL 3.879 mL 4.8487 mL
10 mM 0.097 mL 0.4849 mL 0.9697 mL 1.9395 mL 2.4244 mL
50 mM 0.0194 mL 0.097 mL 0.1939 mL 0.3879 mL 0.4849 mL
100 mM 0.0097 mL 0.0485 mL 0.097 mL 0.1939 mL 0.2424 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chonglou Saponin VII

Quantitative evaluation and discrimination of wild Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz from three regions of Yunnan Province using UHPLC-UV-MS and UV spectroscopy couple with partial least squares discriminant analysis.[Pubmed:27665609]

J Nat Med. 2017 Jan;71(1):148-157.

Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz (PPY) is used widely as an anthelmintic, antimicrobial, and anti-tumor agent. Multiplicate analytical methods have been employed to discriminate PPY from different regions, as well as to identify regions most beneficial to the growing of this species. In this study, a convenient and accurate method was established using ultra high performance liquid chromatography (UHPLC) for simultaneous determination of four steroid saponins (Pa, Pb, polyphyllin VI, and Chonglou Saponin VII). Partial least squares discriminant analysis (PLS-DA) according to UHPLC and UV spectroscopy was applied to analyze 30 samples of PPY from three regions of Yunnan Province in China, and identify significant peaks. The results indicated that the correlation coefficients (r (2)) of all calibration curves were above 0.999, and the inter- and intra-day relative standard deviations (RSD) of retention time and peak areas of common peaks were below 1.78 % and 3.40 %, respectively, with recovery rates of 99.6-103.4 % with RSD

[Effects of Paris polyphylla saponin VII plus silica nano composite on ovarian cancer drug resistance in vitro].[Pubmed:26712407]

Zhonghua Yi Xue Za Zhi. 2015 Jun 16;95(23):1859-61.

OBJECTIVE: To explore the drug resistance of Chonglou Saponin VII plus silica nano complex for ovarian cancer. METHODS: The method of thiazolyl blue tetrazolium blue (MTT) was employed for determining the proliferation inhibition rate of Chonglou Saponin VII plus silica nano composite for SKOV3/DDP drug-resistant human ovarian cancer cell. Flow cytometry and Hoechst 33342 staining were used for detecting apoptosis rate and cell cycle phase distribution. And the changes of apoptosis-related protein were examined by immunoblot assay. RESULTS: There were obvious inhibitory effects of Chonglou Saponin VII on cell proliferation. The inhibition rate increased with rising drug concentration with an obvious dose-effect relationship (P < 0.05). At the same time, the cell proliferation inhibition rate significantly improved at 48 h versus 24 h (P < 0.05). Flow cytometry and Hoechst 33342 staining showed that, after a 24 h treatment of SKOV3/DDP cells with 50 and 100 micromol/L Chonglou Saponin VII, early apoptotic cell ratio significantly increased compared with control group. CONCLUSION: The composite of Paris polyphylla saponin VII and silica nano has obvious proliferation inhibitory effects on SKOV3/DDP cells. And there is a significant concentration dependence and it also has some correlation with time. The above composite can increased the proportion of early apoptotic cell ratio.

Description

Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.

Keywords:

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