Home >> Research Area >>Natural Products>>Flavonoids>> 4',5,7-Trihydroxy-6-prenylflavone

4',5,7-Trihydroxy-6-prenylflavone

CAS# 68097-13-2

4',5,7-Trihydroxy-6-prenylflavone

Catalog No. BCN4238----Order now to get a substantial discount!

Product Name & Size Price Stock
4',5,7-Trihydroxy-6-prenylflavone: 5mg $725 In Stock
4',5,7-Trihydroxy-6-prenylflavone: 10mg Please Inquire In Stock
4',5,7-Trihydroxy-6-prenylflavone: 20mg Please Inquire Please Inquire
4',5,7-Trihydroxy-6-prenylflavone: 50mg Please Inquire Please Inquire
4',5,7-Trihydroxy-6-prenylflavone: 100mg Please Inquire Please Inquire
4',5,7-Trihydroxy-6-prenylflavone: 200mg Please Inquire Please Inquire
4',5,7-Trihydroxy-6-prenylflavone: 500mg Please Inquire Please Inquire
4',5,7-Trihydroxy-6-prenylflavone: 1000mg Please Inquire Please Inquire

Quality Control of 4',5,7-Trihydroxy-6-prenylflavone

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Chemical structure

4',5,7-Trihydroxy-6-prenylflavone

3D structure

Chemical Properties of 4',5,7-Trihydroxy-6-prenylflavone

Cas No. 68097-13-2 SDF Download SDF
PubChem ID 10382485 Appearance Yellow powder
Formula C20H18O5 M.Wt 338.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)chromen-4-one
SMILES CC(=CCC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=C(C=C3)O)O)C
Standard InChIKey VJDRSTHNWHVTNQ-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 4',5,7-Trihydroxy-6-prenylflavone

The herbs of Garcinia hanburyi Hook.f.

Biological Activity of 4',5,7-Trihydroxy-6-prenylflavone

Description1. 6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. 2. 6-Prenylapigenin shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines.

4',5,7-Trihydroxy-6-prenylflavone Dilution Calculator

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4',5,7-Trihydroxy-6-prenylflavone Molarity Calculator

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Preparing Stock Solutions of 4',5,7-Trihydroxy-6-prenylflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 4',5,7-Trihydroxy-6-prenylflavone

Artocarpus plants as a potential source of skin whitening agents.[Pubmed:21941923]

Nat Prod Commun. 2011 Sep;6(9):1397-402.

Artocarpus plants have been a focus of constant attention due to the potential for skin whitening agents. In the in vitro experiment, compounds from the Artocarpus plants, such as artocarpanone, norartocarpetin, artocarpesin, artogomezianol, andalasin, artocarbene, and chlorophorin showed tyrosinase inhibitory activity. Structure-activity investigations revealed that the 4-substituted resorcinol moiety in these compounds was responsible for their potent inhibitory activities on tyrosinase. In the in vitro assay, using B16 melanoma cells, the prenylated polyphenols isolated from Artocarpus plants, such as artocarpin, cudraflavone C, 6-prenylapigenin, kuwanon C, norartocarpin, albanin A, cudraflavone B, and brosimone I showed potent inhibitory activity on melanin formation. Structure-activity investigations revealed that the introduction of an isoprenoid moiety to a non-isoprenoid-substituted polyphenol enhanced the inhibitory activity of melanin production in B16 melanoma cells. In the in vivo investigation, the extract of the wood of Artocarpus incisus and a representative isolated compound from it, artocarpin had a lightening effect on the skin of guinea pigs' backs. Other in vivo experiments using human volunteers have shown that water extract of Artocarpus lakoocha reduced the melanin formation in the skin of volunteers. These results indicate that the extracts of Artocarpus plants are potential sources for skin whitening agents.

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