SD-06

CAS# 271576-80-8

SD-06

Catalog No. BCC1937----Order now to get a substantial discount!

Product Name & Size Price Stock
SD-06: 5mg $414 In Stock
SD-06: 10mg Please Inquire In Stock
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Quality Control of SD-06

Number of papers citing our products

Chemical structure

SD-06

3D structure

Chemical Properties of SD-06

Cas No. 271576-80-8 SDF Download SDF
PubChem ID 9865587 Appearance Powder
Formula C20H20ClN5O2 M.Wt 397.87
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 50 mg/mL (125.67 mM; Need ultrasonic)
Chemical Name 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone
SMILES C1CN(CCC1C2=C(C(=NN2)C3=CC=C(C=C3)Cl)C4=NC=NC=C4)C(=O)CO
Standard InChIKey CATQHDWESBRRQA-UHFFFAOYSA-N
Standard InChI InChI=1S/C20H20ClN5O2/c21-15-3-1-13(2-4-15)19-18(16-5-8-22-12-23-16)20(25-24-19)14-6-9-26(10-7-14)17(28)11-27/h1-5,8,12,14,27H,6-7,9-11H2,(H,24,25)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

SD-06 Dilution Calculator

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SD-06 Molarity Calculator

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Preparing Stock Solutions of SD-06

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5134 mL 12.5669 mL 25.1338 mL 50.2677 mL 62.8346 mL
5 mM 0.5027 mL 2.5134 mL 5.0268 mL 10.0535 mL 12.5669 mL
10 mM 0.2513 mL 1.2567 mL 2.5134 mL 5.0268 mL 6.2835 mL
50 mM 0.0503 mL 0.2513 mL 0.5027 mL 1.0054 mL 1.2567 mL
100 mM 0.0251 mL 0.1257 mL 0.2513 mL 0.5027 mL 0.6283 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

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University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
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The University of Michigan
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Jilin University
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Wuhan University
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Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
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Auckland University
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The University of Tokyo
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Korea University
Korea University

Background on SD-06

SD-06 is a p38 MAP kinase inhibitor. SD-06 inhibits p38α with an IC50 value of 170nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).

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References on SD-06

Identification of a bovine viral diarrhea virus 2 isolated from cattle in China.[Pubmed:19537915]

Acta Virol. 2009;53(2):131-4.

The identification and characterization of bovine viral diarrhea virus 2 (BVDV-2) strain SD-06 isolated from cattle in China is reported. We performed sequence analysis of 5'-untranslated region (5'-UTR) and E2 sequences and the identity at the nucleotide and amino acid level indicated that the isolate was closely related to BVDV-2. The BVDV-2 strain New York'93 showed the highest sequence homology with the isolate SD-06. The phylogenetic analysis revealed that the isolate SD-06 belonged to BVDV-2a subtype. Furthermore, immunofluorescence assay with the monoclonal antibody specific for BVDV-2 glycoprotein E2 confirmed this identification. Thus, the strain SD-06 was the first isolate of BVDV-2 identified in China.

Description

SD 0006 (SD-06) is an orally active, selective, ATP-competitive and potent diaryl pyrazole inhibitor of p38α MAP kinase, with an IC50 of 110 nM for p38α.

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