Bis[4-(2-hydroxyethoxy)phenyl] sulfoneCAS# 27205-03-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 27205-03-4 | SDF | Download SDF |
PubChem ID | 95071 | Appearance | Powder |
Formula | C16H18O6S | M.Wt | 338.4 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 2-[4-[4-(2-hydroxyethoxy)phenyl]sulfonylphenoxy]ethanol | ||
SMILES | C1=CC(=CC=C1OCCO)S(=O)(=O)C2=CC=C(C=C2)OCCO | ||
Standard InChIKey | UTNSTOOXQPHXJQ-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C16H18O6S/c17-9-11-21-13-1-5-15(6-2-13)23(19,20)16-7-3-14(4-8-16)22-12-10-18/h1-8,17-18H,9-12H2 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Bis[4-(2-hydroxyethoxy)phenyl] sulfone Dilution Calculator
Bis[4-(2-hydroxyethoxy)phenyl] sulfone Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | 59.1017 mL | 73.8771 mL |
5 mM | 0.591 mL | 2.9551 mL | 5.9102 mL | 11.8203 mL | 14.7754 mL |
10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL | 5.9102 mL | 7.3877 mL |
50 mM | 0.0591 mL | 0.2955 mL | 0.591 mL | 1.182 mL | 1.4775 mL |
100 mM | 0.0296 mL | 0.1478 mL | 0.2955 mL | 0.591 mL | 0.7388 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Ampelopsin
Catalog No.:BCN5160
CAS No.:27200-12-0
- 2-Acetamidothiazole
Catalog No.:BCC8509
CAS No.:2719-23-5
- FH1(BRD-K4477)
Catalog No.:BCC5341
CAS No.:2719-05-3
- LY 393558
Catalog No.:BCC7660
CAS No.:271780-64-4
- Thonningianin A
Catalog No.:BCN2774
CAS No.:271579-11-4
- SD-06
Catalog No.:BCC1937
CAS No.:271576-80-8
- 3-Tritylmercapto-Propionicacid
Catalog No.:BCC2846
CAS No.:27144-18-9
- Thevetin B
Catalog No.:BCN4046
CAS No.:27127-79-3
- MMK 1
Catalog No.:BCC6037
CAS No.:271246-66-3
- Paradol
Catalog No.:BCC1837
CAS No.:27113-22-0
- Solasurine
Catalog No.:BCN2694
CAS No.:27028-76-8
- H-D-Glu(OMe)-OMe.HCl
Catalog No.:BCC2941
CAS No.:27025-25-8
- Polydatin
Catalog No.:BCN5949
CAS No.:27208-80-6
- Miltirone
Catalog No.:BCN5356
CAS No.:27210-57-7
- Pedunsaponin C
Catalog No.:BCN8193
CAS No.:272120-53-3
- Decursidate
Catalog No.:BCN4044
CAS No.:272122-56-2
- Cyanidin 3-Arabinoside
Catalog No.:BCC8157
CAS No.:27214-72-8
- Neoandrographolide
Catalog No.:BCN4657
CAS No.:27215-14-1
- N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide
Catalog No.:BCC9051
CAS No.:27262-40-4
- Levobupivacaine HCl
Catalog No.:BCC4675
CAS No.:27262-48-2
- Phyllostine
Catalog No.:BCN4773
CAS No.:27270-89-9
- ICI 63197
Catalog No.:BCC7188
CAS No.:27277-00-5
- Tirapazamine
Catalog No.:BCC5184
CAS No.:27314-97-2
- 5-Formyl-2-furylboronic acid
Catalog No.:BCC8748
CAS No.:27329-70-0
Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities.[Pubmed:25192815]
Toxicol In Vitro. 2015 Feb;29(1):8-15.
A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industrial chemicals that disrupt endocrine activity were selected for evaluation of potential (anti)glucocorticoid and (anti)androgenic activities. The human breast carcinoma MDA-kb2 cell line was utilized for reporter gene assays, since it expresses both the androgen and the glucocorticoid-responsive reporter. Two new antiandrogens, 4,4'-sulfonylbis(2-methylphenol) (dBPS) and 4,4'-thiodiphenol (THIO), and two new antiglucocorticoids, bisphenol Z and its analog Bis[4-(2-hydroxyethoxy)phenyl] sulfone (BHEPS) were identified. Moreover, four new glucocorticoid agonists (methyl paraben, ethyl paraben, propyl paraben and bisphenol F) were found. To elucidate the structure-activity relationship of bisphenols, we performed molecular docking experiments with androgen and glucocorticoid receptor. These docking experiments had shown that bulky structures such as BHEPS and bisphenol Z act as antiglucocorticoid, because they are positioned toward helix H12 in the antagonist conformation and could therefore be responsible for H12 conformational change and the switch between agonistic and antagonistic conformation of receptor. On the other hand smaller structures cannot interact with H12. The results of in vitro screening of fifteen industrial chemicals as modulators of the glucocorticoid and androgen receptor activities demand additional in vivo testing of these chemicals for formulating any relevant hazard identification to human health.