Levobupivacaine HClCAS# 27262-48-2 |
- Alarelin Acetate
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| Cas No. | 27262-48-2 | SDF | Download SDF |
| PubChem ID | 117965 | Appearance | Powder |
| Formula | C18H29ClN2O | M.Wt | 324.89 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (S)-(-)-Bupivacaine monohydrochloride | ||
| Solubility | DMSO : ≥ 47 mg/mL (144.66 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride | ||
| SMILES | [Cl-].CCCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C.[H+] | ||
| Standard InChIKey | SIEYLFHKZGLBNX-NTISSMGPSA-N | ||
| Standard InChI | InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H/t16-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Levobupivacaine Hcl is a local anaesthetic compound belonging to the amino amide group; long-acting local anesthetic. References: | |||||
Levobupivacaine HCl Dilution Calculator
Levobupivacaine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.078 mL | 15.3898 mL | 30.7796 mL | 61.5593 mL | 76.9491 mL |
| 5 mM | 0.6156 mL | 3.078 mL | 6.1559 mL | 12.3119 mL | 15.3898 mL |
| 10 mM | 0.3078 mL | 1.539 mL | 3.078 mL | 6.1559 mL | 7.6949 mL |
| 50 mM | 0.0616 mL | 0.3078 mL | 0.6156 mL | 1.2312 mL | 1.539 mL |
| 100 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.6156 mL | 0.7695 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Levobupivacaine HCl, the pure S(-)-enantiomer of bupivacaine, is a long-acting local anesthetic.
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Stability of sufentanil citrate with levobupivacaine HCl in NaCl 0.9% infusion after microwave freeze-thaw treatment.[Pubmed:15454582]
Ann Pharmacother. 2004 Nov;38(11):1836-9.
BACKGROUND: Sufentanil is a powerful central anesthetic and analgesic of the opiate family that can be used with levobupivacaine for epidural administration. Advance preparation of intravenous solution could be useful to improve quality, time management, and cost-savings of drug delivery. OBJECTIVE: To investigate how freezing, long-term storage, and microwave thawing can affect the stability of sufentanil citrate and Levobupivacaine HCl in NaCl 0.9% (saline) (w/v) polyvinyl chloride (PVC) bags. METHODS: The stability of 5 bags of solution containing sufentanil 500 microg and levobupivacaine 625 mg per 500 mL of saline solution in PVC bags was studied after freezing for 4 months at -30 degrees C, thawing in a microwave oven with a validated cycle, and storage at 4 degrees C. The concentrations of the drugs were measured by HPLC using a reversed-phase column, a mobile phase consisting of 18% acetonitrile (v/v) in tertabutyl ammonium hydrogen sulfate buffer 0.03 M pH 3.00 +/- 0.05, and UV detection at 235 nm for sufentanil and 260 nm for levobupivacaine. Visual inspection and pH measurement were also performed. RESULTS: No color change or precipitation was observed. Sufentanil and levobupivacaine were stable for at least 70 days at 4 degrees C after freezing and thawing. Throughout this period, the 95% lower confidence limit of the concentration-time profile remained >90% of the initial concentration. During this period, the pH value remained stable. CONCLUSIONS: Within the limits defined here, a mixture of sufentanil citrate and Levobupivacaine HCl may be prepared in advance and kept frozen.
