4'-Hydroxy-7-methoxyflavanCAS# 27348-54-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 27348-54-5 | SDF | Download SDF |
| PubChem ID | 185609 | Appearance | Cryst. |
| Formula | C16H16O3 | M.Wt | 256.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-[(2S)-7-methoxy-3,4-dihydro-2H-chromen-2-yl]phenol | ||
| SMILES | COC1=CC2=C(CCC(O2)C3=CC=C(C=C3)O)C=C1 | ||
| Standard InChIKey | HQIYVJDLRVEGDX-HNNXBMFYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 4'-Hydroxy-7-methoxyflavan shows an important cytotoxic effect against human leukemic Molt 4 cells. |
4'-Hydroxy-7-methoxyflavan Dilution Calculator
4'-Hydroxy-7-methoxyflavan Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9017 mL | 19.5084 mL | 39.0168 mL | 78.0336 mL | 97.5419 mL |
| 5 mM | 0.7803 mL | 3.9017 mL | 7.8034 mL | 15.6067 mL | 19.5084 mL |
| 10 mM | 0.3902 mL | 1.9508 mL | 3.9017 mL | 7.8034 mL | 9.7542 mL |
| 50 mM | 0.078 mL | 0.3902 mL | 0.7803 mL | 1.5607 mL | 1.9508 mL |
| 100 mM | 0.039 mL | 0.1951 mL | 0.3902 mL | 0.7803 mL | 0.9754 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Studies on flavans. 1. Facile synthesis of (+/-)-7-hydroxy-3',4'-methylenedioxyflavan and (+/-)-4'-hydroxy-7-methoxyflavan by a BF3.Et2O-mediated pyran cyclization.[Pubmed:11430003]
J Nat Prod. 2001 Feb;64(2):214-6.
A facile approach for the synthesis of flavans was developed by employing a BF3.Et2O-catalyzed pyran cyclization in an aprotic polar solvent as a key step, by which concise total syntheses of (+/-)-7-hydroxy-3',4'-methylenedioxyflavan (1) and (+/-)-4'-hydroxy-7-methoxyflavan (2), two naturally occurring flavans, were achieved.
A new flavan from the Drynaria bonii H. Christ rhizomes.[Pubmed:26230303]
Nat Prod Res. 2016;30(7):761-7.
In Vietnam, the medicinal plant Drynaria bonii H. Christ is used for the treatment of osteoporosis, bone fractures, and stimulate the growth of hair, treat tinnitus (Ho 2002; Loi 2004). In this article, experiments were designed to investigate the proliferation activity of ethanol, n-hexane, chloroform, ethyl acetate and methanol extracts from D. bonii rhizomes on MG-63 human osteoblast-like cells. The results showed that methanol and hexane extracts had the ability to proliferate MG-63 cells at the concentration varying from 0.1 to 0.01 mug/mL. In particular, at the concentration of 0.01 mug/mL, hexane and methanol extracts illustrated the highest proliferation ratio with 9.31% and 6.16%, respectively. By column chromatography, a new compound named drynaether A (1) and five known compounds uracil (2), 4'-hydroxy-7-methoxyflavan (3), kaempferol (4), indole-3-carboxylic acid (5) and protocatechuic acid (6) were isolated and identified from the methanol extract.
Cytotoxic activity of Amaryllidaceae alkaloids from Crinum augustum and Crinum bulbispermum.[Pubmed:1798796]
Planta Med. 1991 Oct;57(5):437-9.
The cytotoxic activity of five minor Amaryllidaceae alkaloids and one flavan isolated from Crinum augustum Rox and Crinum bulbispermum Milne were tested on human leukemic Molt 4 cells. Whereas the crinine-type alkaloids (6 alpha-hydroxycrinine, powelline) and the new type augustamine did not even inhibit the growth of Molt 4 cells, the lycorine-type alkaloid (pratorinine) and the crinine-type alkaloid (6 alpha-hydroxybuphanisine) showed a moderate cytotoxic activity and the flavan (4'-hydroxy-7-methoxyflavan) showed an important cytotoxic effect.
