SalvioloneCAS# 119400-86-1 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 119400-86-1 | SDF | Download SDF |
| PubChem ID | 10355691 | Appearance | Yellow cryst. |
| Formula | C18H20O2 | M.Wt | 268.4 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-hydroxy-4,4,8-trimethyl-2,3-dihydro-1H-cyclohepta[a]naphthalen-10-one | ||
| SMILES | CC1=C(C(=O)C=C2C3=C(C=CC2=C1)C(CCC3)(C)C)O | ||
| Standard InChIKey | QATRODNHXVHGNU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H20O2/c1-11-9-12-6-7-15-13(5-4-8-18(15,2)3)14(12)10-16(19)17(11)20/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Salvia miltiorrhiza
| Description | 1. Salviolone exhibits cytotoxic activity against Vero cells. 2. Salviolone has a benzotropolone moiety has been isolated together with two other nor- and bisnorditerpenes 1 and 2 from the fresh root . |
Salviolone Dilution Calculator
Salviolone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7258 mL | 18.6289 mL | 37.2578 mL | 74.5156 mL | 93.1446 mL |
| 5 mM | 0.7452 mL | 3.7258 mL | 7.4516 mL | 14.9031 mL | 18.6289 mL |
| 10 mM | 0.3726 mL | 1.8629 mL | 3.7258 mL | 7.4516 mL | 9.3145 mL |
| 50 mM | 0.0745 mL | 0.3726 mL | 0.7452 mL | 1.4903 mL | 1.8629 mL |
| 100 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.7452 mL | 0.9314 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- 2,5-Dihydroxybenzaldehyde
Catalog No.:BCN6081
CAS No.:1194-98-5
- mAChR-IN-1
Catalog No.:BCC5512
CAS No.:119391-56-9
- 2-Deacetoxytaxinine J
Catalog No.:BCN7291
CAS No.:119347-14-7
- CRANAD 2
Catalog No.:BCC6293
CAS No.:1193447-34-5
- 2-Hydroxydiplopterol
Catalog No.:BCN7290
CAS No.:1193250-54-2
- Olean-12-ene-3,24-diol
Catalog No.:BCN6079
CAS No.:119318-15-9
- 2-Benzyl-2-(dimethylamino)-4'-morpholinobutyrophenone
Catalog No.:BCC8563
CAS No.:119313-12-1
- Pinobanksin 5-methyl ether
Catalog No.:BCN7775
CAS No.:119309-36-3
- Atalantoflavone
Catalog No.:BCN4857
CAS No.:119309-02-3
- Rocuronium Bromide
Catalog No.:BCC1068
CAS No.:119302-91-9
- PE 154
Catalog No.:BCC7858
CAS No.:1192750-33-6
- Scutellarin methylester
Catalog No.:BCN2828
CAS No.:119262-68-9
New Products
- Przewalskin
Catalog No.:BCN6080
CAS No.:119400-87-2
- LY2811376
Catalog No.:BCC2102
CAS No.:1194044-20-6
- Topotecan hydrochloride
Catalog No.:BCN2604
CAS No.:119413-54-6
- Licoricesaponin E2
Catalog No.:BCN7894
CAS No.:119417-96-8
- Galanin (1-30) (human)
Catalog No.:BCC6961
CAS No.:119418-04-1
- Loureirin A
Catalog No.:BCN3671
CAS No.:119425-89-7
- Loureirin B
Catalog No.:BCN5021
CAS No.:119425-90-0
- Eliprodil
Catalog No.:BCC7280
CAS No.:119431-25-3
- Fruquintinib(HMPL-013)
Catalog No.:BCC6415
CAS No.:1194506-26-7
- Meropenem trihydrate
Catalog No.:BCC4226
CAS No.:119478-56-7
- Ethyllucidone
Catalog No.:BCN6082
CAS No.:1195233-59-0
- Ceanothic acid acetate
Catalog No.:BCN6083
CAS No.:119533-63-0
Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway.[Pubmed:30610802]
J BUON. 2018 Nov-Dec;23(6):1739-1744.
PURPOSE: Cervical cancer is one of the prevalently diagnosed cancers in women worldwide. In this study the antiproliferative and anticancer effects of Salviolone were evaluated against HeLa cervical cancer cell line along with determining the anticancer mode of action. METHODS: MTT assay was employed to examine the proliferation rate of HeLa cells. Transmission electron microscopy (TEM) was used for the detection of the autophagic cell death. The cell invasion and migration were investigated by transwell assay and the expression of the proteins was estimated by western blotting. RESULTS: The results revealed that Salviolone exerts anticancer effects on the HeLa cells with an IC50 of 20 microM. The effect of Salviolone on the viability of normal FR-2 cells was very low. TEM analysis showed that Salviolone triggers autophagic cell death in HeLa cells. Salviolone could also cause arrest of the HeLa cervical cancer cells in the G2/M phase of the cell cycle and suppress their ability to migrate and invade. Western blotting analysis revealed that Salviolone could inhibit the of Nf-kB/m-TOR/PI3K/AKT signalling pathway in HeLa cells. CONCLUSION: Taken all together, it is concluded that Salviolone could prove to be an important lead molecule for the treatment of cervical cancer.
Salviolone,119400-86-1,Natural Products, buy Salviolone , Salviolone supplier , purchase Salviolone , Salviolone cost , Salviolone manufacturer , order Salviolone , high purity Salviolone
