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Licoricesaponin E2

CAS# 119417-96-8

Licoricesaponin E2

Catalog No. BCN7894----Order now to get a substantial discount!

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Quality Control of Licoricesaponin E2

Number of papers citing our products

Chemical structure

Licoricesaponin E2

3D structure

Chemical Properties of Licoricesaponin E2

Cas No. 119417-96-8 SDF Download SDF
PubChem ID 86278258 Appearance Powder
Formula C42H60O16 M.Wt 820.92
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC8(CC7OC8=O)C)C)C)C)C
Standard InChIKey ACCYCJOHUMRMMV-NHJGESHHSA-N
Standard InChI InChI=1S/C42H60O16/c1-37(2)20-8-11-42(7)31(19(43)14-17-18-15-38(3)16-22(55-36(38)53)39(18,4)12-13-41(17,42)6)40(20,5)10-9-21(37)54-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h14,18,20-31,34-35,44-48H,8-13,15-16H2,1-7H3,(H,49,50)(H,51,52)/t18-,20-,21-,22+,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35+,38+,39+,40-,41+,42+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Licoricesaponin E2

The roots of Glycyrrhiza uralensis

Biological Activity of Licoricesaponin E2

Description1. Licoricesaponin E2 displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 umol/L, it could significantly increase the cytotoxic activity after hydrolysis.

Licoricesaponin E2 Dilution Calculator

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Licoricesaponin E2 Molarity Calculator

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Preparing Stock Solutions of Licoricesaponin E2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2181 mL 6.0907 mL 12.1815 mL 24.3629 mL 30.4536 mL
5 mM 0.2436 mL 1.2181 mL 2.4363 mL 4.8726 mL 6.0907 mL
10 mM 0.1218 mL 0.6091 mL 1.2181 mL 2.4363 mL 3.0454 mL
50 mM 0.0244 mL 0.1218 mL 0.2436 mL 0.4873 mL 0.6091 mL
100 mM 0.0122 mL 0.0609 mL 0.1218 mL 0.2436 mL 0.3045 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Licoricesaponin E2

Chemical constituents of triterpenoid saponins from Glycyrrhiza uralensis.

Chinese Traditional & Herbal Drugs, 2013, 44(12):1552-1557.

To study the chemical constituents from the roots and rhizomes of Glycyrrhiza uralensis. Methods: The compounds were separated and purified by solvent and chromatographic methods. Their structures were identified by spectroscopic techniques. Results: Fourteen triterpenoid saponins isolated from 50% ethanol extract of the roots and rhizomes of G. uralensis were identified as uralsaponin C (1), uralsaponin D (2), licorice-saponin A3 (3), uralsaponin F (4), 22β-acetoxyl-glycyrrizin (5), 24-hydroxyl-licorice-saponin E2 (6), Licoricesaponin E2 (7), licorice-saponin G2 (8), 22β-acetoxyl-glyrrhaldehyde (9), 3β-O-[β-D-glucuronopyranosyl-(1→2) - β-D-glucuronopyranosyl]-glycyrretol (10), araboglycyrrhizin (11), licorice-saponin J2 (12), glycyrrhizin (13), and glycyrrhetic acid monoglucuronide (14). Compounds 1-14 showed the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μmol/L. The aglycones of compounds 2, 6-8, and 13 displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 μmol/L. Conclusion: Compound 14 is a new natural product, and compound 11 is isolated from the plant for the first time; Compounds 1-14 show no cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721, and the aglycones of compounds 2, 6-8, and 13 could significantly increase the cytotoxic activity after hydrolysis.

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