Sclareol glycolCAS# 38419-75-9 |
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| Cas No. | 38419-75-9 | SDF | Download SDF |
| PubChem ID | 11107904 | Appearance | Powder |
| Formula | C16H30O2 | M.Wt | 254.41 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol | ||
| SMILES | CC1(CCCC2(C1CCC(C2CCO)(C)O)C)C | ||
| Standard InChIKey | AIALTZSQORJYNJ-LQKXBSAESA-N | ||
| Standard InChI | InChI=1S/C16H30O2/c1-14(2)8-5-9-15(3)12(14)6-10-16(4,18)13(15)7-11-17/h12-13,17-18H,5-11H2,1-4H3/t12-,13+,15-,16+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Sclareol glycol (SG) behaves as an anxiogenic, memory-facilitator and perhaps adaptogenic agent, the effects of SG may be mediated by different mechanisms of action (stimulation of adenylate cyclase, interaction with GABA-ergic and dopaminergic transmitter mechanisms). 2. Sclareol glycol shows inhibitory effects on clonidine-induced aggressive behavior, which are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action. 3. Sclareol glycol induces changes in core body temperature by interacting with dopamine (DA) receptors and with the second messenger system of 3',5'-AMP in the brain thermoregulatory areas. |
| Targets | Dopamine Receptor | GABA Receptor |
Sclareol glycol Dilution Calculator
Sclareol glycol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9307 mL | 19.6533 mL | 39.3066 mL | 78.6133 mL | 98.2666 mL |
| 5 mM | 0.7861 mL | 3.9307 mL | 7.8613 mL | 15.7227 mL | 19.6533 mL |
| 10 mM | 0.3931 mL | 1.9653 mL | 3.9307 mL | 7.8613 mL | 9.8267 mL |
| 50 mM | 0.0786 mL | 0.3931 mL | 0.7861 mL | 1.5723 mL | 1.9653 mL |
| 100 mM | 0.0393 mL | 0.1965 mL | 0.3931 mL | 0.7861 mL | 0.9827 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice.[Pubmed:2623007]
Pharmacol Biochem Behav. 1989 Nov;34(3):503-5.
The effects of a reversible activator of adenylate cyclase Sclareol glycol (SG), a semisynthetic diterpene of the labdane family, on the aggressive behavior induced by a high dose of clonidine in mice were studied. SG was applied at doses well below the lethal dose. Aggressive behavior induced by clonidine at a dose of 30 mg/kg IP was decreased in a dose-dependent manner by SG (1, 5, 25 mg/kg IP). The aggressive responses were abolished by doses of 50 and 100 mg/kg. It is suggested that the inhibitory effects of SG on clonidine-induced aggressive behavior are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action.
Effects of the diterpene sclareol glycol on body temperature in rats.[Pubmed:2755274]
Methods Find Exp Clin Pharmacol. 1989 Apr;11(4):277-80.
The effects of the diterpene Sclareol glycol (SG) of the labdane family on rectal body temperature in rats were studied. Sclareol glycol induced dose-dependent changes in temperature. At the lowest dose (5 mg/kg) SG produced a decrease followed by an increase in temperature; at the middle dose it produced a decrease and at the largest dose, an increase in rectal temperature. Sclareol glycol caused changes in apomorphine-induced hypothermia (at the low and middle doses it reversed hypothermia, and at the high dose hypothermia was enhanced). Sclareol glycol produced a dose-dependent reversal of reserpine-induced hypothermia. These results suggest that the diterpene Sclareol glycol induces changes in core body temperature by interacting with dopamine (DA) receptors and with the second messenger system of 3',5'-AMP in the brain thermoregulatory areas.
[Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level].[Pubmed:2553391]
Eksp Med Morfol. 1989;28(3):1-7.
Sclareol glycol (SG) is a semisynthetic diterpene of the labdanic group. SG is tetranorlabdaniol bivalent alcohol 13, 14, 15, 16-tetranorlabdan-8 alpha, 12-diol, obtained from the plant Salvia sclarea L., grown in Bulgaria. The effects of SG were studied on the level of 3',5'-AMP in:mono-layer tissue cultures of the anterior hypophysis of the rat; in hypophysial and brain tissue during in vitro incubation; in liver microsomes of the rat during in vitro incubation and in liver perfusate of the rat. It was established that SG induced an increase in accumulation of 3,5'-AMP in the tissues from the anterior hypophyses of mature and newborn rats, in the sections of brain cortex and cerebellum of mature rats. Similar changes were found by the diterpene forskolin, studied comparatively. SG induced a reduction of accumulation of 3',5'-AMP in liver microsomes and diminished the release of 3',5'-AMP in a liver perfusate of the rat. The increased accumulation of 3',5'-AMP due to SG could be explained by postreceptor stimulation of the enzyme adenylate cyclase, binding directly to its catalytic subunit. The reduced accumulation of 3',5'-AMP in liver microsomes and its diminished release in liver perfusate could be explained either by activation of the inhibitory adenylate cyclase in hepatocytes or by desensitisation of 3',5'-AMP-generating system.
Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol.[Pubmed:2156119]
Methods Find Exp Clin Pharmacol. 1990 Jan-Feb;12(1):5-10.
In a punished drinking test in rats Sclareol glycol (SG) decreased the number of punished responses ("proconflict response") while diazepam had the opposite effect; SG antagonized the "anticonflict response" of diazepam. Post-training administration of SG in rats enhanced retention in active avoidance task evaluated 24 h later. SG produced an increase in plasma ACTH and corticosterone levels in unstressed rats. The stress-induced increase in ACTH and corticosterone secretion was potentiated by SG. All these data suggest that SG behaves as an anxiogenic, memory-facilitator and perhaps adaptogenic agent. The effects of SG may be mediated by different mechanisms of action (stimulation of adenylate cyclase, interaction with GABA-ergic and dopaminergic transmitter mechanisms).
Influences of diterpene sclareol glycol on some dopamine related behavior.[Pubmed:2055429]
Gen Pharmacol. 1991;22(2):331-5.
1. The effects of the diterpene Sclareol glycol (SG) of the labdane family on some dopamine (DA) related behavior (locomotor activity in mice, apomorphine-induced stereotypy in mice and rats, and haloperidol-induced catalepsy in rats) were studied. 2. The locomotion frequency of mice was significantly increased by SG (stronger effect by low and medium dose). SG antagonized the hypomotility induced by reserpine pretreatment. SG enhanced the apomorphine decreased motility (induced by small dose of apomorphine). 3. SG provoked increase of apomorphine stereotypy. The long-term SG treatment augmented the sensitivity of rats to apomorphine-induced stereotypy. 4. SG at low dose decreased haloperidol-induced catalepsy: at higher dose it increased the catalepsy. SG treatment alone did not induce catalepsy. 5. These results were discussed in the light of a possible interaction of SG with dopaminergic transmission (DA autoreceptors and postsynaptic DA receptors) at the level of the striatum and the nucleus accumbens. The interaction of SG with adenylate cyclase (stimulation of catalytic subunit) and with GABAergic transmission in realization of its effects on DA related behavior was also discussed.
