Sclareol glycol

CAS# 38419-75-9

Sclareol glycol

Catalog No. BCN7007----Order now to get a substantial discount!

Product Name & Size Price Stock
Sclareol glycol: 5mg Please Inquire In Stock
Sclareol glycol: 10mg Please Inquire In Stock
Sclareol glycol: 20mg Please Inquire Please Inquire
Sclareol glycol: 50mg Please Inquire Please Inquire
Sclareol glycol: 100mg Please Inquire Please Inquire
Sclareol glycol: 200mg Please Inquire Please Inquire
Sclareol glycol: 500mg Please Inquire Please Inquire
Sclareol glycol: 1000mg Please Inquire Please Inquire

Quality Control of Sclareol glycol

Number of papers citing our products

Chemical structure

Sclareol glycol

3D structure

Chemical Properties of Sclareol glycol

Cas No. 38419-75-9 SDF Download SDF
PubChem ID 11107904 Appearance Powder
Formula C16H30O2 M.Wt 254.41
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol
SMILES CC1(CCCC2(C1CCC(C2CCO)(C)O)C)C
Standard InChIKey AIALTZSQORJYNJ-LQKXBSAESA-N
Standard InChI InChI=1S/C16H30O2/c1-14(2)8-5-9-15(3)12(14)6-10-16(4,18)13(15)7-11-17/h12-13,17-18H,5-11H2,1-4H3/t12-,13+,15-,16+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Sclareol glycol

The plants of Salvia sclarea L.

Biological Activity of Sclareol glycol

Description1. Sclareol glycol (SG) behaves as an anxiogenic, memory-facilitator and perhaps adaptogenic agent, the effects of SG may be mediated by different mechanisms of action (stimulation of adenylate cyclase, interaction with GABA-ergic and dopaminergic transmitter mechanisms). 2. Sclareol glycol shows inhibitory effects on clonidine-induced aggressive behavior, which are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action. 3. Sclareol glycol induces changes in core body temperature by interacting with dopamine (DA) receptors and with the second messenger system of 3',5'-AMP in the brain thermoregulatory areas.
TargetsDopamine Receptor | GABA Receptor

Sclareol glycol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Sclareol glycol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Sclareol glycol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9307 mL 19.6533 mL 39.3066 mL 78.6133 mL 98.2666 mL
5 mM 0.7861 mL 3.9307 mL 7.8613 mL 15.7227 mL 19.6533 mL
10 mM 0.3931 mL 1.9653 mL 3.9307 mL 7.8613 mL 9.8267 mL
50 mM 0.0786 mL 0.3931 mL 0.7861 mL 1.5723 mL 1.9653 mL
100 mM 0.0393 mL 0.1965 mL 0.3931 mL 0.7861 mL 0.9827 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Sclareol glycol

Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice.[Pubmed:2623007]

Pharmacol Biochem Behav. 1989 Nov;34(3):503-5.

The effects of a reversible activator of adenylate cyclase Sclareol glycol (SG), a semisynthetic diterpene of the labdane family, on the aggressive behavior induced by a high dose of clonidine in mice were studied. SG was applied at doses well below the lethal dose. Aggressive behavior induced by clonidine at a dose of 30 mg/kg IP was decreased in a dose-dependent manner by SG (1, 5, 25 mg/kg IP). The aggressive responses were abolished by doses of 50 and 100 mg/kg. It is suggested that the inhibitory effects of SG on clonidine-induced aggressive behavior are realized mainly via its effect on adenylate cyclase and perhaps involving synaptic transmitter action.

Effects of the diterpene sclareol glycol on body temperature in rats.[Pubmed:2755274]

Methods Find Exp Clin Pharmacol. 1989 Apr;11(4):277-80.

The effects of the diterpene Sclareol glycol (SG) of the labdane family on rectal body temperature in rats were studied. Sclareol glycol induced dose-dependent changes in temperature. At the lowest dose (5 mg/kg) SG produced a decrease followed by an increase in temperature; at the middle dose it produced a decrease and at the largest dose, an increase in rectal temperature. Sclareol glycol caused changes in apomorphine-induced hypothermia (at the low and middle doses it reversed hypothermia, and at the high dose hypothermia was enhanced). Sclareol glycol produced a dose-dependent reversal of reserpine-induced hypothermia. These results suggest that the diterpene Sclareol glycol induces changes in core body temperature by interacting with dopamine (DA) receptors and with the second messenger system of 3',5'-AMP in the brain thermoregulatory areas.

[Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level].[Pubmed:2553391]

Eksp Med Morfol. 1989;28(3):1-7.

Sclareol glycol (SG) is a semisynthetic diterpene of the labdanic group. SG is tetranorlabdaniol bivalent alcohol 13, 14, 15, 16-tetranorlabdan-8 alpha, 12-diol, obtained from the plant Salvia sclarea L., grown in Bulgaria. The effects of SG were studied on the level of 3',5'-AMP in:mono-layer tissue cultures of the anterior hypophysis of the rat; in hypophysial and brain tissue during in vitro incubation; in liver microsomes of the rat during in vitro incubation and in liver perfusate of the rat. It was established that SG induced an increase in accumulation of 3,5'-AMP in the tissues from the anterior hypophyses of mature and newborn rats, in the sections of brain cortex and cerebellum of mature rats. Similar changes were found by the diterpene forskolin, studied comparatively. SG induced a reduction of accumulation of 3',5'-AMP in liver microsomes and diminished the release of 3',5'-AMP in a liver perfusate of the rat. The increased accumulation of 3',5'-AMP due to SG could be explained by postreceptor stimulation of the enzyme adenylate cyclase, binding directly to its catalytic subunit. The reduced accumulation of 3',5'-AMP in liver microsomes and its diminished release in liver perfusate could be explained either by activation of the inhibitory adenylate cyclase in hepatocytes or by desensitisation of 3',5'-AMP-generating system.

Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol.[Pubmed:2156119]

Methods Find Exp Clin Pharmacol. 1990 Jan-Feb;12(1):5-10.

In a punished drinking test in rats Sclareol glycol (SG) decreased the number of punished responses ("proconflict response") while diazepam had the opposite effect; SG antagonized the "anticonflict response" of diazepam. Post-training administration of SG in rats enhanced retention in active avoidance task evaluated 24 h later. SG produced an increase in plasma ACTH and corticosterone levels in unstressed rats. The stress-induced increase in ACTH and corticosterone secretion was potentiated by SG. All these data suggest that SG behaves as an anxiogenic, memory-facilitator and perhaps adaptogenic agent. The effects of SG may be mediated by different mechanisms of action (stimulation of adenylate cyclase, interaction with GABA-ergic and dopaminergic transmitter mechanisms).

Influences of diterpene sclareol glycol on some dopamine related behavior.[Pubmed:2055429]

Gen Pharmacol. 1991;22(2):331-5.

1. The effects of the diterpene Sclareol glycol (SG) of the labdane family on some dopamine (DA) related behavior (locomotor activity in mice, apomorphine-induced stereotypy in mice and rats, and haloperidol-induced catalepsy in rats) were studied. 2. The locomotion frequency of mice was significantly increased by SG (stronger effect by low and medium dose). SG antagonized the hypomotility induced by reserpine pretreatment. SG enhanced the apomorphine decreased motility (induced by small dose of apomorphine). 3. SG provoked increase of apomorphine stereotypy. The long-term SG treatment augmented the sensitivity of rats to apomorphine-induced stereotypy. 4. SG at low dose decreased haloperidol-induced catalepsy: at higher dose it increased the catalepsy. SG treatment alone did not induce catalepsy. 5. These results were discussed in the light of a possible interaction of SG with dopaminergic transmission (DA autoreceptors and postsynaptic DA receptors) at the level of the striatum and the nucleus accumbens. The interaction of SG with adenylate cyclase (stimulation of catalytic subunit) and with GABAergic transmission in realization of its effects on DA related behavior was also discussed.

Keywords:

Sclareol glycol,38419-75-9,Natural Products, buy Sclareol glycol , Sclareol glycol supplier , purchase Sclareol glycol , Sclareol glycol cost , Sclareol glycol manufacturer , order Sclareol glycol , high purity Sclareol glycol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: