SetiptilineSerotonin receptor antagonist CAS# 57262-94-9 |
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Quality Control & MSDS
3D structure
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| Cas No. | 57262-94-9 | SDF | Download SDF |
| PubChem ID | 5205 | Appearance | Powder |
| Formula | C19H19N | M.Wt | 261.36 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 25 mg/mL (95.65 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
| SMILES | CN1CCC2=C(C1)C3=CC=CC=C3CC4=CC=CC=C24 | ||
| Standard InChIKey | GVPIXRLYKVFFMK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Setiptiline Dilution Calculator
Setiptiline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8261 mL | 19.1307 mL | 38.2614 mL | 76.5228 mL | 95.6535 mL |
| 5 mM | 0.7652 mL | 3.8261 mL | 7.6523 mL | 15.3046 mL | 19.1307 mL |
| 10 mM | 0.3826 mL | 1.9131 mL | 3.8261 mL | 7.6523 mL | 9.5654 mL |
| 50 mM | 0.0765 mL | 0.3826 mL | 0.7652 mL | 1.5305 mL | 1.9131 mL |
| 100 mM | 0.0383 mL | 0.1913 mL | 0.3826 mL | 0.7652 mL | 0.9565 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. From Wikipedia.
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Sensitive determination of mianserin and setiptiline in body fluids by gas chromatography with surface ionization detection (GC-SID).[Pubmed:12935454]
Leg Med (Tokyo). 2000 Aug;2(2):115-8.
Tetracyclic antidepressants, mianserin and Setiptiline, in human body fluids have been found measurable with high sensitivity by gas chromatography (GC) with surface ionization detection (SID). The compounds in human whole blood or urine samples were extracted by solid-phase extraction using Bond Elut C(18) cartridges. The recoveries of both compounds from the body fluids were above 85%. For quantitation of mianserin, 25 ng of Setiptiline was used as internal standard; and for quantitation of Setiptiline, vice versa. The calibration curves for spiked whole blood or urine samples were linear in the range of 1.25-50 ng/ml. The detection limit of mianserin and Setiptiline was about 1 ng/ml, which is comparable to those obtained by the previous GC-mass spectrometry methods. Our method seems very useful for determination of mianserin and Setiptiline in forensic and clinical toxicology, because of high sensitivity, low background impurities and easy handling of the GC instrument.
Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia.[Pubmed:7516085]
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46.
1. Setiptiline maleate was administered to schizophrenic patients with the object of improving their negative symptoms. 2. Moderate improvements were observed in 58% of the treated patients, thus usefulness of this drug was demonstrated. 3. There was no aggravation of symptoms, and side effects were minor. 4. Measurements of plasma monoamine metabolites showed a tendency of MHPG to decrease and a significant decrease in 5-HIAA, but no change in the level of HVA was observed, suggesting a relationship between the negative symptoms and noradrenaline and/or serotonin systems.
The effect of age on plasma level of setiptiline maleate in depressed patients.[Pubmed:7824756]
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):1015-26.
1. Setiptiline maleate (SPT) was administered orally to 45 subjects aged 22-86 years and steady state plasma levels were determined by mass fragment chromatography (GC-MF) to examine the effect of aging on those values. 2. There was a significant correlation between the plasma levels and daily dose. However, there was a wide interindividual variability. 3. Dose-corrected plasma level (DC-PL), or values corrected by dividing the plasma level by daily dose/body weight, was used as the systemic drug clearance parameter. 4. DC-PL was compared among 7 age groups of the subjects distributed in 10-year-intervals. DC-PL showed no difference among groups of subjects between the > 29 years bracket to the 70 years bracket, but showed significantly higher values in those in the > 80 bracket compared to all age groups and subjects in the < 79 bracket. 5. There was a significant correlation between the age of patients and DC-PL according to polynomial response curve analysis. Regression analysis yielded the equation y = -52.72 + 7.05 x -0.17 x2 + 0.01 x3 (n = 45, r = 0.49, p < 0.01).
[Effect of lithium, carbamazepine, and setiptiline on diacylglycerol in rat brain ex vivo].[Pubmed:8048280]
Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Feb;14(1):33-8.
The effect of lithium on diacylglycerol (DAG), which is an intracellular second messenger, was compared with those of carbamazepine and Setiptiline ex vivo through phosphatidylinositol turnover (PI response). Consequently, (1) PI response cycling by stimulation of norepinephrine participated in the alpha 1 receptor. (2) DAG accumulation in rat brain exhibited a biphasic pattern. (3) Lithium elevated DAG accumulation at 30 seconds after stimulation by norepinephrine. (4) Carbamazepine did not affect DAG accumulation. (5) Setiptiline decreased DAG accumulation at 30 minutes after stimulation by norepinephrine.
