Adrenergic Receptor - GPCR/G protein

Cat.No. Product Name Information

BCC4329 Maprotiline HCl Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

BCC7521 Atipamezole hydrochloride Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

BCC4344 Bisoprolol fumarate (±)-Bisoprolol (hemifumarate) is a selective type β1 adrenergic receptor blocker.

BCC6728 Spiroxatrine

BCC6912 A 61603 hydrobromide

BCC7021 RX 821002 hydrochloride

BCC6947 (S)-(+)-Niguldipine hydrochloride

BCC7094 SR 59230A hydrochloride SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.

BCC4326 Dexmedetomidine Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.

BCC7833 SR 58611A hydrochloride Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.

BCC5741 RS 100329 hydrochloride

BCC6893 CGP 20712 dihydrochloride

BCC7835 NPEC-caged-noradrenalin

BCC7449 JP 1302 dihydrochloride JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM.

BCC6860 BRL 37344, sodium salt BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.

BCC6852 ZD 7114 hydrochloride

BCC6705 3-MPPI 3-MPPI

BCC6881 Pindolol Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

BCC7490 Alprenolol hydrochloride Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.

BCC6726 2-PMDQ 2-PMDQ

BCC5688 ICI 215,001 hydrochloride

BCC4347 Dexmedetomidine HCl Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.

BCC4350 Ivabradine HCl Ivabradine hydrochloride is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.

BCC6741 2-MPMDQ 2-MPMDQ

BCC7091 CL 316243 disodium salt

BCC7336 A 80426 mesylate

BCC4332 Nebivolol Nebivolol hydrochloride selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM.

BCC7350 SNAP 5089

BCC7282 L-755,507 L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM.

BCN2164 Silodosin Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH.

BCC6874 RS 17053 hydrochloride RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.

BCC7628 Rec 15/2615 dihydrochloride

BCC5878 ZD 2079 ZD 2079

BCC6883 AH 11110 hydrochloride

BCC6876 RS 79948 hydrochloride

BCC1919 Salmefamol

BCC4081 Prazosin Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

BCC2505 Prazosin HCl Prazosin hydrochloride is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

BCC6858 WB 4101 hydrochloride

BCC3814 Mirabegron (YM178) Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.

BCC4320 Terbutaline Sulfate Terbutaline sulfate is a β2-adrenergic receptor agonist; a fast-acting bronchodilator and a tocolytic to delay premature labor.

BCC4341 Xylazine HCl Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.

BCC4333 Oxymetazoline HCl

BCC4337 Ritodrine HCl Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.

BCC4327 Guanabenz Acetate Guanabenz (Acetate) (BR-750) is an alpha-2 selective adrenergic agonist used as an antihypertensive agent.

BCC7475 L-748,337

BCC6086 RWJ 52353

BCC7991 TC-G 1000

BCC6657 Dihydroergocristine mesylate Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively.

BCC6813 Agmatine sulfate Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

BCC6916 (S)-(-)-Pindolol

BCC4340 Timolol Maleate (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction.

BCC5180 Guanfacine Guanfacine is a selective α2A receptor agonist.

BCC1609 Guanfacine hydrochloride Guanfacine hydrochloride, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.

BCC6683 HEAT hydrochloride

BCC1650 Indacaterol Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptor agonist.

BCC4336 Propranolol HCl Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol hydrochloride is used to control hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. Propranolol HCl

BCC5489 Labetalol HCl Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure.

BCC4318 DL-Adrenaline DL-Epinephrine is the racemate of epinephrine. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

BCC4322 Acebutolol HCl Acebutolol hydrochloride is a β1 adrenergic receptor (β1AR) antagonist. Acebutolol hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

BCC7474 B-HT 933 dihydrochloride

BCC6911 Zinterol hydrochloride Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.

BCC4356 Sotalol Sotalol

BCC7098 SDZ 21009

BCC6833 Cirazoline hydrochloride Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM).

BCC7527 DSP-4 DSP-4 hydrochloride (Neurotoxin DSP 4 hydrochloride) is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats, can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC). DSP-4

BCC6809 (S)-(-)-Propranolol hydrochloride

BCC4325 Clonidine HCl Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent.

BCC4349 Formoterol Hemifumarate Formoterol fumarate(Foradil) is a potent, selective and long-acting β2-adrenoceptor agonist.

BCC7436 ST 91 ST 91

BCC5391 Dobutamine hydrochloride Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

BCN1940 Scopine Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. Scopine

BCC4030 Vilanterol Vilanterol (GW642444) is a long-acting β2-adrenoceptor (β2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

BCC4031 Vilanterol trifenatate Vilanterol trifenatate (GW642444 trifenatate) is a long-acting β2-adrenoceptor (β2-AR) agonist with inherent 24-hour activity. The pEC50s for β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

BCC5678 Pronethalol hydrochloride

BCC4328 Isoprenaline HCl Isoprenaline hydrochloride is a non-selective beta-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities.

BCC4348 Epinephrine Bitartrate L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

BCN2191 Adrenaline L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

BCC4338 Salbutamol Sulfate Salbutamol Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.

BCC4082 Tizanidine Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

BCC6466 Carteolol HCl Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma.

BCC4339 Tetrahydrozoline HCl Tetrahydrozoline (hydrochloride) is a α-adrenoceptor agonist.

BCC6807 ICI 89406

BCC6647 Cimaterol

BCC4319 Epinephrine HCl L-Epinephrine hydrochloride ((-)-Epinephrine hydrochloride; L-Adrenaline hydrochloride; (-)-Adrenalin hydrochloride), an endogenous neurotransmitter hormone, is used for the treatment of allergic and respiratory disorders.

BCC4331 Naphazoline HCl Naphazoline hydrochloride is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.

BCC4676 Methyldopa Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

BCC6851 ARC 239 dihydrochloride

BCC4330 Metoprolol Tartrate Metoprolol is a cardioselective β1-adrenergic blocking agent.

BCC4352 Naftopidil Naftopidil (Flivas), a selective α1-adrenergic receptor antagonist or alpha blocker, is an antihypertensive drug.

BCC4355 Naftopidil DiHCl Naftopidil DiHCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.

BCC1945 Setiptiline Setiptiline(Org-8282) is a serotonin receptor antagonist.

BCC1634 HOKU-81 HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. HOKU-81

BCC4321 Tolazoline HCl Tolazoline (hydrochloride)(Imidaline (hydrochloride)) Hcl is a non-selective competitive α-adrenergic receptor antagonist.

BCC4359 Synephrine HCl Synephrine hydrochloride (Oxedrine hydrochloride) is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids.

BCC4335 Phenylephrine HCl (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

BCC4323 Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.

BCC6834 Rauwolscine hydrochloride Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.

BCC6937 Procaterol hydrochloride

BCC4334 Phenoxybenzamine HCl Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma.

Products for Adrenergic Receptor