Ritodrine HClβ-2 adrenergic receptor agonist CAS# 23239-51-2 |
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Quality Control & MSDS
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| Cas No. | 23239-51-2 | SDF | Download SDF |
| PubChem ID | 31728 | Appearance | Powder |
| Formula | C17H22ClNO3 | M.Wt | 323.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride | ||
| SMILES | [Cl-].C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2.[H+] | ||
| Standard InChIKey | IDLSITKDRVDKRV-XHXSRVRCSA-N | ||
| Standard InChI | InChI=1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Ritodrine HCl Dilution Calculator
Ritodrine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0882 mL | 15.4412 mL | 30.8823 mL | 61.7646 mL | 77.2058 mL |
| 5 mM | 0.6176 mL | 3.0882 mL | 6.1765 mL | 12.3529 mL | 15.4412 mL |
| 10 mM | 0.3088 mL | 1.5441 mL | 3.0882 mL | 6.1765 mL | 7.7206 mL |
| 50 mM | 0.0618 mL | 0.3088 mL | 0.6176 mL | 1.2353 mL | 1.5441 mL |
| 100 mM | 0.0309 mL | 0.1544 mL | 0.3088 mL | 0.6176 mL | 0.7721 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ritodrine HCl is a β-2 adrenergic receptor agonist.Ritodrine is a tocolytic drug, used to stop premature labor. Ritodrine can significantly prolong a short interval more quickly but with relatively more side effects than magnesium sulphate. Stratified RCT
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Ritodrine HCL for the prevention of premature labor in twin pregnancies.[Pubmed:801412]
Acta Genet Med Gemellol (Roma). 1976;25:321-4.
The perinatal mortality rate for twin gestation is in the range of 15%, and this is due predominantly to prematurity, although twins may also be born growth retarded. Ritodrine HCl, a beta sympathomimetic drug, has been shown to be effective, both in stopping premature labor and in preventing intrauterine growth retardation. With this in mind, a double-blind study using Ritodrine HCl or placebo was begun in order to study its effect on premature labor, intrauterine growth retardation, and the perinatal mortality rate in twins. Thus far, 30 patients have delivered and have been followed to 6 weeks postpartum. Although the results on individual patients have remained blinded to the investigators, an initial evaluation of the ritodrine and placebo groups have revealed no difference with respect to gestational age, birth weight, or perinatal mortality. These preliminary results are not significant. However, it appears that Ritodrine HCl is a safe oral agent for the antepartum gravida and her fetus. The study will be continued until approximately 100 patients have been enrolled.
Cardiovascular and tocolytic effects of nicardipine HCl in the pregnant rabbit: comparison with ritodrine HCl.[Pubmed:3796925]
Obstet Gynecol. 1987 Jan;69(1):83-7.
The effects of two dosage schedules of nicardipine, a calcium-entry blocker, were studied in the pregnant rabbit during induced preterm uterine contractions and compared with the effects of ritodrine hydrochloride. Uterine activity was inhibited by all treatment regimens, but the most significant inhibition was achieved by the higher dose of nicardipine, which nearly abolished all uterine activity. However, while maternal tachycardia and hypotension were observed during treatment with each of these medications, the most significant drop in blood pressure occurred with high-dose nicardipine. These findings may indicate that nicardipine is a potent tocolytic agent with side effects similar in degree, but of different etiology, than those seen with ritodrine. Additional studies to clarify the effect of nicardipine tocolysis on the fetus are needed before it can be considered for use in human pregnancy.
[The influence of ritodrine-hcl (prepar), bunitrolol (stresson) and oxytocin (syntocinon) on Uteroplacental perfusion (author's transl)].[Pubmed:35885]
Z Geburtshilfe Perinatol. 1979 Apr;183(2):111-7.
The administration of betamimetics has proved to be useful for symptom-oriented treatment in patients with reduced utero-placental flow. In order to quantify the betamimetic effect flow measurements were carried out in a total of 12 sheep, yielding the following experimental results: 1) Betamimetics, up to a certain point which correlates with maternal heart rate, raise the uteroplacental flow-rate. 2) The use of cardio-selective betablocker prevents undesired betamimetic side-effects but there is also a loss of the rise in utero-placental flow rate. 3) In sheep pretreated with Oxytoxin the application of betamimetics not only offsets oxytoxin-action but also greatly improves utero-placental blood flow.
Changes in plasma steroid hormones during treatment of preterm labour with ritodrine-HCl.[Pubmed:6615742]
Br J Obstet Gynaecol. 1983 Sep;90(9):847-53.
Peripheral plasma concentrations of unconjugated oestradiol 17-beta, progesterone and total oestriol were measured in 21 patients presenting with 'uncomplicated' preterm labour. Serial measurements were made during intravenous treatment with ritodrine over a period of 24 h. Mean levels of unconjugated oestradiol 17-beta fell significantly during infusion with ritodrine. Changes in progesterone levels remained within the range of diurnal fluctuations normally found in uncomplicated late pregnancy. Mean total oestriol levels fell significantly, but the changes did not exceed normal variations. No correlation was found between the magnitude, the rate or the timing of changes in any of the hormones measured and the short or long term effects of ritodrine on uterine activity. Although alterations in the peripheral oestrogen concentrations may be a direct effect of beta-mimetics, it is unlikely that this mechanism is important in the inhibition of uterine activity.
