Naphazoline HClCAS# 550-99-2 |
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Quality Control & MSDS
3D structure
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| Cas No. | 550-99-2 | SDF | Download SDF |
| PubChem ID | 11079 | Appearance | Powder |
| Formula | C14H15ClN2 | M.Wt | 246.74 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : 50 mg/mL (202.64 mM; Need ultrasonic) DMSO : ≥ 25 mg/mL (101.32 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride | ||
| SMILES | C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl | ||
| Standard InChIKey | DJDFFEBSKJCGHC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Naphazoline HCl Dilution Calculator
Naphazoline HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0528 mL | 20.2642 mL | 40.5285 mL | 81.057 mL | 101.3212 mL |
| 5 mM | 0.8106 mL | 4.0528 mL | 8.1057 mL | 16.2114 mL | 20.2642 mL |
| 10 mM | 0.4053 mL | 2.0264 mL | 4.0528 mL | 8.1057 mL | 10.1321 mL |
| 50 mM | 0.0811 mL | 0.4053 mL | 0.8106 mL | 1.6211 mL | 2.0264 mL |
| 100 mM | 0.0405 mL | 0.2026 mL | 0.4053 mL | 0.8106 mL | 1.0132 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
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Comparison of Naphcon-A and its components (naphazoline and pheniramine) in a provocative model of allergic conjunctivitis.[Pubmed:8055694]
Curr Eye Res. 1994 May;13(5):319-24.
A double-masked, randomized, parallel group, placebo-controlled study demonstrated the efficacy of Naphcon-A (Naphazoline HCl 0.025% and pheniramine maleate 0.3%). Seventy-two patients with a documented positive skin test or radioallergosorbent test were recruited. Three groups of 24 patients each received 1 drop of Naphcon-A instilled in one eye, and 1 drop of either naphazoline, pheniramine, or placebo in the other eye. After the instillation of test medication, a titrated dose of ragweed antigen was administered bilaterally, and ocular signs and symptoms were evaluated 10, 30, and 120 minutes later. All patients (excluding 4 who had persistent symptoms attributable to ragweed) were rechallenged with ragweed antigen at 120 minutes to assess the duration of action of the test medications. Naphcon-A was significantly more effective than placebo, naphazoline, and pheniramine in reducing redness. Naphcon-A and pheniramine were equally effective in relieving itching.
Topical naphazoline in treatment of myopathic ptosis.[Pubmed:8503264]
Acta Neurol Scand. 1993 Apr;87(4):322-4.
We instilled Naphazoline HCl (0.1%), an imidazole derivative with preferential alpha-2 activity, in 17 eyes of 12 patients with myopathic ptosis due to involvement of the levator palpebrae superioris, in the attempt to selectively stimulate Muller's smooth muscle. Naphazoline significantly widened the palpebral fissure with little change in pupillary diameter and no significant change in ocular pressure, visual acuity and near point determination. However, a reduction of the effect, probably due to tachyphylaxis, was noticed when using naphazoline regularly several times a day for few weeks. In conclusion naphazoline has powerful cosmetical and functional effects in mild to moderate myopathic ptosis above all if taken occasionally.
Intravenous naphazoline intoxication.[Pubmed:7246278]
Acta Med Scand. 1981;209(5):429-30.
Nine pale perspiring drug addicts with drowsiness, nausea, headache, normal blood pressure and marked sinus bradycardia with premature ventricular beats were seen at the Casualty Department soon after alleged i.v. cocaine administration. Eight were treated with atropine, as the bradycardia suggested intoxication with a parasympathomimetic compound. Seven were discharged in good condition after a few hours' observation. One patient developed a blood pressure of 150/120 mmHg after atropine. Subsequently, a hemiparesis was found and an intracerebral haematoma was evaluated at surgery. Another patient was admitted forthwith to the CCU. He did not receive any medication and recovered within two days. Urinalysis of these two patients disclosed contents of naphazoline, a powerful alpha-adrenergic agent. Samples of the alleged cocaine contained 97% Naphazoline HCl. A conscious rabbit was injected with naphazoline and thereafter with atropine. I.v. naphazoline doubled mean arterial pressure (MAP) and reduced heart rate (HR) from 167 to 30 beats/min. Atropine doubled HR, but caused a marked rise in MAP, too, stressing the adverse effects of atropine in these cases. When confronted with patients after alleged cocaine abuse, the role of substitute drugs, especially alpha-adrenergic compounds, should be considered as this should influence the therapeutic approach.
