Skullcapflavone IICAS# 55084-08-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 55084-08-7 | SDF | Download SDF |
| PubChem ID | 124211 | Appearance | Yellow powder |
| Formula | C19H18O8 | M.Wt | 374.4 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxychromen-4-one | ||
| SMILES | COC1=CC=CC(=C1C2=CC(=O)C3=C(O2)C(=C(C(=C3O)OC)OC)OC)O | ||
| Standard InChIKey | GMQFOKBGMKVUQZ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma. |
| Targets | TGF-β/Smad | COX |
| In vivo | Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.[Pubmed: 22314230]Int Immunopharmacol. 2012 Apr;12(4):666-74.Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant. |
| Kinase Assay | Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants.[Pubmed: 10071954]Arch Pharm Res. 1999 Feb;22(1):18-24.Various flavonoid derivatives were previously reported to possess the inhibitory activity on cyclooxygenase/lipoxygenase. And these properties of flavonoids might contribute to their anti-inflammatory activity in vivo. |
Skullcapflavone II Dilution Calculator
Skullcapflavone II Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6709 mL | 13.3547 mL | 26.7094 mL | 53.4188 mL | 66.7735 mL |
| 5 mM | 0.5342 mL | 2.6709 mL | 5.3419 mL | 10.6838 mL | 13.3547 mL |
| 10 mM | 0.2671 mL | 1.3355 mL | 2.6709 mL | 5.3419 mL | 6.6774 mL |
| 50 mM | 0.0534 mL | 0.2671 mL | 0.5342 mL | 1.0684 mL | 1.3355 mL |
| 100 mM | 0.0267 mL | 0.1335 mL | 0.2671 mL | 0.5342 mL | 0.6677 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Andrographolide
Catalog No.:BCN5735
CAS No.:5508-58-7
- Acitretin
Catalog No.:BCC1189
CAS No.:55079-83-9
- Diversoside
Catalog No.:BCN7537
CAS No.:55062-36-7
- Protodioscin
Catalog No.:BCN6274
CAS No.:55056-80-9
- 2,6,4'-Trihydroxy-4-methoxybenzophenone
Catalog No.:BCN7588
CAS No.:55051-85-9
- Dammar-20(21)-en-3,24,25-triol
Catalog No.:BCN5734
CAS No.:55050-69-6
- Isorhamnetin-3-O-neohespeidoside
Catalog No.:BCN1234
CAS No.:55033-90-4
- (±)-Cloprostenol sodium salt
Catalog No.:BCC7315
CAS No.:55028-72-3
- NAADP tetrasodium salt
Catalog No.:BCC7808
CAS No.:5502-96-5
- Naphazoline HCl
Catalog No.:BCC4331
CAS No.:550-99-2
- Lupanine
Catalog No.:BCN5736
CAS No.:550-90-3
- Afrormosine
Catalog No.:BCN3312
CAS No.:550-79-8
- 5,6,7-Trimethoxycoumarin
Catalog No.:BCN7590
CAS No.:55085-47-7
- Nalmefene - d3
Catalog No.:BCC6093
CAS No.:55096-26-9
- EVP-6124 hydrochloride
Catalog No.:BCC1567
CAS No.:550999-74-1
- EVP-6124
Catalog No.:BCC1566
CAS No.:550999-75-2
- 3-Butylidenephthalide
Catalog No.:BCN6345
CAS No.:551-08-6
- Liquiritin
Catalog No.:BCN5944
CAS No.:551-15-5
- 6-Aminopenicillanic acid
Catalog No.:BCC8765
CAS No.:551-16-6
- Viridiflorine
Catalog No.:BCN2045
CAS No.:551-57-5
- Supinine
Catalog No.:BCN1952
CAS No.:551-58-6
- Dimetridazole
Catalog No.:BCC8944
CAS No.:551-92-8
- 2'-Aminoacetophenone
Catalog No.:BCN1746
CAS No.:551-93-9
- 4beta-Carboxy-19-nortotarol
Catalog No.:BCN4065
CAS No.:55102-39-1
Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.[Pubmed:22314230]
Int Immunopharmacol. 2012 Apr;12(4):666-74.
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant. Here, we were investigated its therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Administration of Skullcapflavone II significantly reduced airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and increased transforming growth factor-beta1 (TGF-beta1) levels in bronchoalveolarlavage (BAL) fluids and lungs from OVA-sensitized and -challenged mice. Skullcapflavone II administration also significantly suppressed subepithelial collagen deposition and goblet cell hyperplasia, elevated Smad7 expression and suppressed pSmad2/3 levels. Collectively, these findings indicate that Skullcapflavone II, a potential bradykinin antagonist, reduced the major pathophysiological features of allergic asthma, at least in part by acting on TGF-beta1/Smad signaling pathways. Thus, Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.
Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants.[Pubmed:10071954]
Arch Pharm Res. 1999 Feb;22(1):18-24.
Various flavonoid derivatives were previously reported to possess the inhibitory activity on cyclooxygenase/lipoxygenase. And these properties of flavonoids might contribute to their anti-inflammatory activity in vivo. In this study, several polyhydroxylated/methoxylated flavonoid derivatives such as oroxylin A, wogonin, Skullcapflavone II, tectorigenin and iristectorigenin A were isolated from the medicinal plants. These compounds were evaluated for their inhibitory effects on cyclooxygenase/lipoxygenase from the homogenate of human platelets in vitro. It was found that isoflavones including daidzein and tectorigenin possessed the inhibitory activity on cyclooxygenase, although the potency of inhibition was far less than that of indomethacin. In addition, oroxylin A, baicalein and wogonin inhibited 12-lipoxygenase activity without affecting cyclooxygenase, which suggested that 5,6,7- or 5,7,8-trisubstitutions of A-ring of flavone gave favorable results. The IC50 values of oroxylin A and NDGA against 12-lipoxygenase were found to be 100 and 1.5 microM, respectively.
