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Isorhamnetin-3-O-neohespeidoside

CAS# 55033-90-4

Isorhamnetin-3-O-neohespeidoside

Catalog No. BCN1234----Order now to get a substantial discount!

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Isorhamnetin-3-O-neohespeidoside: 5mg $17 In Stock
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Quality Control of Isorhamnetin-3-O-neohespeidoside

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Chemical structure

Isorhamnetin-3-O-neohespeidoside

3D structure

Chemical Properties of Isorhamnetin-3-O-neohespeidoside

Cas No. 55033-90-4 SDF Download SDF
PubChem ID 11664505 Appearance Yellow powder
Formula C28H32O16 M.Wt 624.54
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Calendoflavoside; 3,4',5,7-Tetrahydroxy 3'-methoxyflavone 3-neohesperidoside
Solubility Soluble in DMSO and methan
Chemical Name 3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one
SMILES CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)OC)CO)O)O)O)O)O
Standard InChIKey QHLKSZBFIJJREC-SPSUIZEHSA-N
Standard InChI InChI=1S/C28H32O16/c1-9-18(33)21(36)23(38)27(40-9)44-26-22(37)19(34)16(8-29)42-28(26)43-25-20(35)17-13(32)6-11(30)7-15(17)41-24(25)10-3-4-12(31)14(5-10)39-2/h3-7,9,16,18-19,21-23,26-34,36-38H,8H2,1-2H3/t9-,16+,18-,19+,21+,22-,23+,26+,27-,28-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isorhamnetin-3-O-neohespeidoside

The barks of Rhamnus purshiana

Biological Activity of Isorhamnetin-3-O-neohespeidoside

DescriptionIsorhamnetin 3-O-neohesperoside is the major active substance of Puhuang, a traditional herb medicine widely used in clinical practice to tackle many chronic diseases. It has significant biological and pharmacological activities, including antioxidant, antiatherogenic and antimicrobial effects.

Protocol of Isorhamnetin-3-O-neohespeidoside

Structure Identification
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:131-7.

Measurement of hydroxysafflor yellow A in human urine by liquid chromatography-tandem mass spectrometry.[Pubmed: 25463208]


METHODS AND RESULTS:
A rapid and specific high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the quantification of hydroxysafflor yellow A (HSYA) in human urine with Isorhamnetin-3-O-neohespeidoside as internal standard (IS). HSYA and IS were extracted from urine samples by simple solid-phase extraction and separated on an Agilent Zorbax SB C18 column (4.6 mm × 150 mm, 5 μm) with the mobile phase of 0.2 mM ammonium acetate: methanol (30/70, v/v) at a flow rate of 0.4 mL/min. Polar endogenous interferences eluted in 0.1-2.5 min were switched into waste channel by the Valve Valco, to reduce the possible matrix effect for MS detection in each run. The MS detection of analytes was performed on a tandem mass spectrometer equipped with an electrospray ionization source in negative mode using multiple-reaction monitoring. The MS/MS ion transitions monitored were m/z 611.3→491.2 for HSYA and m/z 623.2→299.2 for IS. The method was fully validated for selectivity, sensitivity, linearity, precision, accuracy, recovery, matrix effect and stability, and then was applied to the urinary excretion study of injectable powder of pure HSYA in healthy Chinese volunteers for the first time.
CONCLUSIONS:
The results suggested that urine was the main excretion way of HSYA in healthy volunteers, further demonstrating the feasibility and necessity of our current method.

Isorhamnetin-3-O-neohespeidoside Dilution Calculator

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Preparing Stock Solutions of Isorhamnetin-3-O-neohespeidoside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6012 mL 8.0059 mL 16.0118 mL 32.0236 mL 40.0295 mL
5 mM 0.3202 mL 1.6012 mL 3.2024 mL 6.4047 mL 8.0059 mL
10 mM 0.1601 mL 0.8006 mL 1.6012 mL 3.2024 mL 4.0029 mL
50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6405 mL 0.8006 mL
100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Isorhamnetin-3-O-neohespeidoside

Measurement of hydroxysafflor yellow A in human urine by liquid chromatography-tandem mass spectrometry.[Pubmed:25463208]

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 1;974:131-7.

A rapid and specific high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the quantification of hydroxysafflor yellow A (HSYA) in human urine with Isorhamnetin-3-O-neohespeidoside as internal standard (IS). HSYA and IS were extracted from urine samples by simple solid-phase extraction and separated on an Agilent Zorbax SB C18 column (4.6 mm x 150 mm, 5 mum) with the mobile phase of 0.2 mM ammonium acetate: methanol (30/70, v/v) at a flow rate of 0.4 mL/min. Polar endogenous interferences eluted in 0.1-2.5 min were switched into waste channel by the Valve Valco, to reduce the possible matrix effect for MS detection in each run. The MS detection of analytes was performed on a tandem mass spectrometer equipped with an electrospray ionization source in negative mode using multiple-reaction monitoring. The MS/MS ion transitions monitored were m/z 611.3-->491.2 for HSYA and m/z 623.2-->299.2 for IS. The method was fully validated for selectivity, sensitivity, linearity, precision, accuracy, recovery, matrix effect and stability, and then was applied to the urinary excretion study of injectable powder of pure HSYA in healthy Chinese volunteers for the first time. The results suggested that urine was the main excretion way of HSYA in healthy volunteers, further demonstrating the feasibility and necessity of our current method.

Description

Isorhamnetin-3-O-neohespeidoside is a flavonoid isolated from Pollen typhae.

Keywords:

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