Dimetridazole

Microbial Flora Associated with the Halophyte-Salsola imbricate and Its Biotechnical Potential.[Pubmed:29445362]

Front Microbiol. 2018 Jan 31;9:65.

Halophytes are associated with the intertidal forest ecosystem of Saudi Arabia and seemingly have an immense potential for yielding useful and important natural products. In this study we have aimed to isolate and characterize the endophytic and rhizospheric bacterial communities from the halophyte, Salsola imbricata, In addition these bacterial strains were identified and selected strains were further studied for bioactive secondary metabolites. At least 168 rhizspheric and endophytic bacteria were isolated and of these 22 were active antagonists against the oomycetous fungal plant pathogens, Phytophthora capsici and Pythium ultimum. Active cultures were mainly identified with molecular techniques (16S r DNA) and this revealed 95.7-100% sequence similarities with relevant type strains. These microorgansims were grouped into four major classes: Actinobacteria, Firmicutes, beta-Proteobacteria, and gamma-Proteobacteria. Production of fungal cell wall lytic enzymes was detected mostly in members of Actinobacteria and Firmicutes. PCR screening for type I polyketide synthases (PKS-I), type II polyketide synthases (PKS-II) and nonribosomal peptide synthetases (NRPS) revealed 13 of the 22 strains (59%) were positive for at least one of these important biosynthetic genes that are known to be involved in the synthesis of important antibiotics. Four bacterial strains of Actinobacteria with potential antagonistic activity including two rhizobacteria, EA52 (Nocardiopsis sp.), EA58 (Pseudonocardia sp.) and two endophytic bacteria Streptomyces sp. (EA65) and Streptomyces sp. (EA67) were selected for secondary metabolite analyses using LC-MS. As a result, the presence of different bioactive compounds in the culture extracts was detected some of which are already reported for their diverse biological activities including antibiotics such as Sulfamethoxypyridazine, Sulfamerazine, and Dimetridazole. In conclusion, this study provides an insight into antagonistic bacterial population especially the Actinobacteria from S. imbricata, producing antifungal metabolites of medical significance and characterized taxonomically in future.

[Kinetics and Reactive Species Analysis of Dimetridazole Degradation by TiO2].[Pubmed:26911000]

Huan Jing Ke Xue. 2015 Nov;36(11):4135-40.

Dimetridazole is considered as an emerging pollutant in waterbodies, which can potentially impact ecosystem and human health. Heterogeneous photocatalytic decomposition of Dimetridazole by TiO2 was investigated under 365 nm UV light and effects of initial pH, TiO2 content and Dimetridazole concentration on photocatalytic process were discussed. The results indicated that the optimized experiment condition is that the TiO2 content of 1 g x L(-1), Dimetridazole concentration of 40 mg x L (-1), pH of 11, Dimetridazole can be removed 90%. The photocatalytic degradation kinetics of Dimetridazole could be fitted to the quasi-first-order equation. Photocatalytic degradation of Dimetridazole can take place via two pathways: oxidation by *OH and reduction by e -.