Xylazine HCl

α2 Adrenoceptor agonist CAS# 23076-35-9

Xylazine HCl

Catalog No. BCC4341----Order now to get a substantial discount!

Product Name & Size Price Stock
Xylazine HCl: 5mg $6 In Stock
Xylazine HCl: 10mg Please Inquire In Stock
Xylazine HCl: 20mg Please Inquire Please Inquire
Xylazine HCl: 50mg Please Inquire Please Inquire
Xylazine HCl: 100mg Please Inquire Please Inquire
Xylazine HCl: 200mg Please Inquire Please Inquire
Xylazine HCl: 500mg Please Inquire Please Inquire
Xylazine HCl: 1000mg Please Inquire Please Inquire
Related Products
  • XMD17-109

    Catalog No.:BCC2061
    CAS No.:1435488-37-1
  • FR 180204

    Catalog No.:BCC3669
    CAS No.:865362-74-9
  • VRT752271

    Catalog No.:BCC4122
    CAS No.:869886-67-9
  • VX-11e

    Catalog No.:BCC2051
    CAS No.:896720-20-0

Quality Control of Xylazine HCl

Number of papers citing our products

Chemical structure

Xylazine HCl

3D structure

Chemical Properties of Xylazine HCl

Cas No. 23076-35-9 SDF Download SDF
PubChem ID 68554 Appearance Powder
Formula C12H17ClN2S M.Wt 256.79
Type of Compound N/A Storage Desiccate at -20°C
Synonyms BAY 1470 hydrochloride
Solubility DMSO : ≥ 100 mg/mL (389.42 mM)
H2O : ≥ 50 mg/mL (194.71 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine;hydrochloride
SMILES CC1=C(C(=CC=C1)C)NC2=NCCCS2.Cl
Standard InChIKey QYEFBJRXKKSABU-UHFFFAOYSA-N
Standard InChI InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Xylazine HCl

DescriptionXylazine Hydrochloride is α2 class of adrenergic receptor agonist. Target: Adrenergic Receptor Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2].

References:
[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26. [2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.

Xylazine HCl Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Xylazine HCl Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Xylazine HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8942 mL 19.4712 mL 38.9423 mL 77.8847 mL 97.3558 mL
5 mM 0.7788 mL 3.8942 mL 7.7885 mL 15.5769 mL 19.4712 mL
10 mM 0.3894 mL 1.9471 mL 3.8942 mL 7.7885 mL 9.7356 mL
50 mM 0.0779 mL 0.3894 mL 0.7788 mL 1.5577 mL 1.9471 mL
100 mM 0.0389 mL 0.1947 mL 0.3894 mL 0.7788 mL 0.9736 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Xylazine HCl

Xylazine HCl is a strong agonist of α2-adrenoceptor [1].

Xylazine HCl has been reported to stimulate the proliferation of rat thymocytes in vivo (at doses of 2.5 mg/kg and 5 mg/kg) and in vitro (at concentration of 5 mM) [2]. In the analgesic testing, Xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. In addition, Xylazine has also shown the inhibitory effect in the mouse vas deferens bioassay with the IC50 value of 18nM. Furthermore, Xylazine has displayed a potent specific [3H]-dihydromorphine binding inhibition with the IC50 value of 8μM in opiate receptor binding test [1].

References:
[1] S.  BROWNING, D.LAWRENCE1, A.LIVINGSTON & B.MORRIS. Interaction of drugs active at opiate receptors and drugs active at α2-adrenoceptors on various test systems
[2] Colić M1, Cupić V, Pavicić L, Vucević D, Varagić VM.  Xylazine, an alpha 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find Exp Clin Pharmacol. 2000 Sep;22(7):557-62.

Featured Products
New Products
 

Description

Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.

Keywords:

Xylazine HCl,23076-35-9,BAY 1470 hydrochloride,Natural Products,Adrenergic Receptor, buy Xylazine HCl , Xylazine HCl supplier , purchase Xylazine HCl , Xylazine HCl cost , Xylazine HCl manufacturer , order Xylazine HCl , high purity Xylazine HCl

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: