Pronethalol hydrochlorideCAS# 51-02-5 |
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Quality Control & MSDS
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| Cas No. | 51-02-5 | SDF | Download SDF |
| PubChem ID | 60975 | Appearance | Powder |
| Formula | C15H20ClNO | M.Wt | 265.78 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | ICI-38174 | ||
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol;hydrochloride | ||
| SMILES | CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O.Cl | ||
| Standard InChIKey | QONLGXRPRAIDGI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H19NO.ClH/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14;/h3-9,11,15-17H,10H2,1-2H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | β-adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias. |
Pronethalol hydrochloride Dilution Calculator
Pronethalol hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.7625 mL | 18.8126 mL | 37.6251 mL | 75.2502 mL | 94.0628 mL |
| 5 mM | 0.7525 mL | 3.7625 mL | 7.525 mL | 15.05 mL | 18.8126 mL |
| 10 mM | 0.3763 mL | 1.8813 mL | 3.7625 mL | 7.525 mL | 9.4063 mL |
| 50 mM | 0.0753 mL | 0.3763 mL | 0.7525 mL | 1.505 mL | 1.8813 mL |
| 100 mM | 0.0376 mL | 0.1881 mL | 0.3763 mL | 0.7525 mL | 0.9406 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Gastric, intestinal and colonic absorption of a series of beta-blockers in the rat.[Pubmed:1356102]
Int J Clin Pharmacol Ther Toxicol. 1992 Aug;30(8):280-6.
Gastric, intestinal and colonic absorption rates of a series of eleven beta-blockers (alprenolol hydrochloride, atenolol, bunolol hydrochloride, penbutolol sulphate, Pronethalol hydrochloride, metoprolol, oxprenolol, bevantolol, bufuralol, propranolol hydrochloride and timolol maleate) were estimated using Doluisio's method. The gastric absorption rate was very low and the absorption rate constant could not be assessed accurately in all cases. In the small intestine, the absorption rate constants, Ka, at pH 6.2 ranged between 0.38 h-1 for atenolol and 4.28 h-1 for penbutolol. In the colon, the rate of drug absorption at pH 7.5 ranged between 0.12 h-1 for atenolol and 2.15 h-1 for penbutolol. In most cases, colonic absorption rate constants were of the same order as those obtained in the small intestine, demonstrating the good penetrability through colonic membrane of the series studied. The relationship between absorption rate constants found in the small intestine and colon and the partition constant ([1/Rf]-1), was studied for this non-homologous series of beta-blocker drugs. In both cases, the functional hyperbolic absorption model proposed by Wagner and Sedman [1973] was the most representative.
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