Sibiriquinone BCAS# 723300-09-2 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 723300-09-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Red powder |
| Formula | C19H22O2 | M.Wt | 282.41 |
| Type of Compound | Other Quinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Sibiriquinone B Dilution Calculator
Sibiriquinone B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.541 mL | 17.7048 mL | 35.4095 mL | 70.819 mL | 88.5238 mL |
| 5 mM | 0.7082 mL | 3.541 mL | 7.0819 mL | 14.1638 mL | 17.7048 mL |
| 10 mM | 0.3541 mL | 1.7705 mL | 3.541 mL | 7.0819 mL | 8.8524 mL |
| 50 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.4164 mL | 1.7705 mL |
| 100 mM | 0.0354 mL | 0.177 mL | 0.3541 mL | 0.7082 mL | 0.8852 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.[Pubmed:17583950]
J Nat Prod. 2007 Jul;70(7):1093-7.
The hypoxia-inducible factor-1 (HIF-1) has been known to be correlated to the adaptation and proliferation of tumor cells; therefore HIF-1 has become an important target in the development of anticancer drugs. A phytochemical study of the CHCl3-soluble fraction of Salvia miltiorrhiza, which strongly inhibited hypoxia-induced reporter gene expression, led to the isolation of 12 abietane-type diterpenes. Of these compounds, sibiriquinone A (1), Sibiriquinone B (2), cryptotanshinone (3), and dihydrotanshinone I (4) potently inhibited hypoxia-induced luciferase expression with IC50 values of 0.34, 3.36, 1.58, and 2.05 microM on AGS cells, a human gastric cancer cell line, and 0.28, 3.18, 1.36, and 2.29 microM on Hep3B cells, a human hepatocarcinoma cell line, respectively. Consistently, 1 and 4 dose-dependently suppressed the HIF-1alpha accumulation and 1 inhibited mRNA expression of vascular endothelial growth factor (VEGF) under hypoxia. These results suggest that the anticancer activity of tanshinones is likely at least in part associated with their inhibition of HIF-1 accumulation.
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