Suffruticosol DCAS# 1261292-11-8 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1261292-11-8 | SDF | Download SDF |
| PubChem ID | 46830467 | Appearance | Brown powder |
| Formula | C42H32O9 | M.Wt | 680.7 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-[(2R,3R,5R,6S)-3-(3,5-dihydroxyphenyl)-2,6-bis(4-hydroxyphenyl)-4-[(E)-2-(4-hydroxyphenyl)ethenyl]-2,3,5,6-tetrahydrofuro[3,2-f][1]benzofuran-5-yl]benzene-1,3-diol | ||
| SMILES | C1=CC(=CC=C1C=CC2=C3C(C(OC3=CC4=C2C(C(O4)C5=CC=C(C=C5)O)C6=CC(=CC(=C6)O)O)C7=CC=C(C=C7)O)C8=CC(=CC(=C8)O)O)O | ||
| Standard InChIKey | PHIHHTIYURVLDB-SIXZTWGTSA-N | ||
| Standard InChI | InChI=1S/C42H32O9/c43-27-8-1-22(2-9-27)3-14-34-39-35(50-41(23-4-10-28(44)11-5-23)37(39)25-15-30(46)19-31(47)16-25)21-36-40(34)38(26-17-32(48)20-33(49)18-26)42(51-36)24-6-12-29(45)13-7-24/h1-21,37-38,41-49H/b14-3+/t37-,38-,41-,42+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Suffruticosol D Dilution Calculator
Suffruticosol D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.4691 mL | 7.3454 mL | 14.6908 mL | 29.3815 mL | 36.7269 mL |
| 5 mM | 0.2938 mL | 1.4691 mL | 2.9382 mL | 5.8763 mL | 7.3454 mL |
| 10 mM | 0.1469 mL | 0.7345 mL | 1.4691 mL | 2.9382 mL | 3.6727 mL |
| 50 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.5876 mL | 0.7345 mL |
| 100 mM | 0.0147 mL | 0.0735 mL | 0.1469 mL | 0.2938 mL | 0.3673 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- N-(3-(4-Fluorophenyl)propyl)-7-hydroxycoumarin-3-carboxamide
Catalog No.:BCX0264
CAS No.:2136579-33-2
- Assiguxanthone B
Catalog No.:BCX0263
CAS No.:197447-29-3
- Pruniflorone R
Catalog No.:BCX0262
CAS No.:1238102-65-2
- (2S,3S)-Pterosin S 14-O-glucoside
Catalog No.:BCX0261
CAS No.:62043-50-9
- Sanggenon O
Catalog No.:BCX0260
CAS No.:101664-32-8
- Sibiriquinone B
Catalog No.:BCX0259
CAS No.:723300-09-2
- Suffruticosol B
Catalog No.:BCX0258
CAS No.:220936-87-8
- Arucadiol
Catalog No.:BCX0257
CAS No.:105037-85-2
- (E)-α-Atlantone
Catalog No.:BCX0256
CAS No.:26294-59-7
- (E)-4-(4-Hydroxyphenyl)but-3-en-2-one
Catalog No.:BCX0255
CAS No.:22214-30-8
- Dulcisxanthone B
Catalog No.:BCX0254
CAS No.:869669-62-5
- Chasmanthin
Catalog No.:BCX0253
CAS No.:20379-19-5
- Isogarcinol
Catalog No.:BCX0266
CAS No.:71117-97-0
- (E)-Eucomin
Catalog No.:BCX0267
CAS No.:17934-08-6
- Marsdenoside I
Catalog No.:BCX0268
CAS No.:872993-75-4
- Daphnetin 8-O-glucoside
Catalog No.:BCX0269
CAS No.:20853-56-9
- Euryanoside
Catalog No.:BCX0270
CAS No.:125300-52-9
- Suffruticosol A
Catalog No.:BCX0271
CAS No.:220936-82-3
- 6α-Hydroxystigmast-4-en-3-one
Catalog No.:BCX0272
CAS No.:75686-40-7
- Kushenol Q
Catalog No.:BCX0273
CAS No.:952491-35-9
- Suffruticosol C
Catalog No.:BCX0274
CAS No.:220936-94-7
- 6-(4-Hydroxyphenyl)-2-methylhept-2-en-4-one
Catalog No.:BCX0275
CAS No.:949081-06-5
- Lup-20(29)-ene-2α,3α-diol
Catalog No.:BCX0276
CAS No.:55476-83-0
- Trijugin C
Catalog No.:BCX0277
CAS No.:1233534-45-6
[Simultaneous rapid detection of ten stilbenes in serum of mice by UPLC-MS/MS].[Pubmed:32495569]
Zhongguo Zhong Yao Za Zhi. 2020 May;45(9):2180-2185.
Stilbenes is a class of natural polyphenols with 1,2-diphenylethylene as the skeleton structure which have structural and active diversity. However, there are fewer studies on their metabolic process, which limits the in-depth research and development of such components. An UPLC-MS/MS method simultaneously determining contents of ten stilbenes was firstly established in this study and applied to study the ten stilbenes of peony seed coats in the serum of C57 mice.Piceatannol was the internal standard, and methanol was used for protein precipitation, UPLC-MS/MS with negative ion mode was used for analysis, and the method was validated.The serum samples were collected and detected after mice being oral administered with 800 mg.kg~(-1) peony seed coat extracts for 8 weeks. The results showed that suffruticosol A, suffruticosol B, suffruticosol C, trans-epsilon-viniferin, cis-gnetin H, trans-Suffruticosol D and trans-gnetin H were detected in serum samples, and the highest is suffruticosol A. The method is simple and quick with high specificity and sensitivity, and it is suitable for quantitative determination of ten stilbenes in the serum of mice.
[Determination of ten stilbenes and their antioxidant activity of peony seed coat, seed kernel and seed coat extracts].[Pubmed:28875674]
Zhongguo Zhong Yao Za Zhi. 2016 Mar;41(6):1081-1086.
The seed of tree peony and herbaceous peony contained a variety of stilbenes which possess many pharmacological activities, such as antitumor, anti-inflammatory, allergy and neuraminidase inhibition. In order to develop and use peony seed resources, a simple and sensitive HPLC-DAD was developed for simultaneous determination of 10 stilbenes in peony samples, i.e.,suffruticosol A,suffruticosol B,suffruticosol C,trans-resveratrol,cis-epsilon-viniferin,trans-epsilon-viniferin,cis-Suffruticosol D,cis-gnetin H,trans-Suffruticosol D and trans-gnetin H. At the same time, the scavenging activity of DPPH free radicals was employed to evaluate their antioxidant effect. The results showed that the 10 stilbenes are mainly present in peony seed coat (total content of more than 16.7%) compared to peony seed kernel (total content less than 0.3%), and can be enriched in the extract of peony seed coat (total content of more than 75%) The extract of peony seed coat and 10 stilbenes exhibited significant antioxidant properties. This work provides a foundation for comprehensive utilization of the tree peony and herbaceous peony seed resources.
In vitro antitumor effects of two novel oligostilbenes, cis- and trans-suffruticosol D, isolated from Paeonia suffruticosa seeds.[Pubmed:26647827]
Int J Oncol. 2016 Feb;48(2):646-56.
Naturally derived stilbenes have been shown to elicit cytotoxic, anti-steroidal, anti-mutagenic, anti-oxidative, anti-inflammatory, and antitumor bioactivities. Previous phytochemical studies revealed that the seeds of Paeonia suffruticosa are rich in natural stilbenes. In this study the antitumor effects and mechanism of action of the oligostilbene isomers, cis- and trans-Suffruticosol D, isolated from the seeds of P. suffruticosa were examined. cis- and trans-Suffruticosol D exhibited remarkable cytotoxicity against the human cancer cell lines A549 (lung), BT20 (breast), MCF-7 (breast), and U2OS (osteosarcoma), but showed significantly less toxicity to the normal human cell lines HMEC (breast) and HPL1A (lung). We also demonstrated that cis- and trans-Suffruticosol D exerted their antitumor effects by provoking oxidative stress, stimulating apoptosis, decreasing the mitochondrial membrane potential, inhibiting cell motility, and blocking the NF-kappaB pathway in human lung cancer cells. In addition, we evaluated their respective bioefficacy and found that trans-Suffruticosol D is more potent than cis-Suffruticosol D. Collectively, our results suggest that cis- and trans-Suffruticosol D could be promising chemotherapeutic agents against cancer.
Three new oligostilbenes from the seeds of Paeonia suffruticosa.[Pubmed:20522997]
Chem Pharm Bull (Tokyo). 2010 Jun;58(6):843-7.
Three new oligostilbenes, trans-Suffruticosol D (1), cis-Suffruticosol D (2), and cis-gnetin H (7), were isolated along with the eight known stilbenes, trans-resveratrol (3), trans-epsilon-viniferin (4), cis-epsilon-viniferin (5), gnetin H (6), suffruticosol A (8), suffruticosol B (9), suffruticosol C (10), and cis-ampelopsin E (11) from the seeds of Paeonia suffruticosa. Compounds 3-6 were isolated for the first time from this plant species, and compound 11 was isolated for the first time from the genus Paeonia. The structures of the new compounds were elucidated based on spectral analyses, including 1D and 2D NMR experiments. The absolute configuration of compound 1 was determined by quantum chemical calculation of the electronic circular dichroism and comparison with the experimental circular dichroism spectrum.
