Spectinomycin dihydrochlorideCAS# 21736-83-4 |
- JNK-IN-7
Catalog No.:BCC1672
CAS No.:1408064-71-0
- CC-401 hydrochloride
Catalog No.:BCC1458
CAS No.:1438391-30-0
- CEP 1347
Catalog No.:BCC7982
CAS No.:156177-65-0
- AEG 3482
Catalog No.:BCC8088
CAS No.:63735-71-7
- AS 602801
Catalog No.:BCC1369
CAS No.:848344-36-5
- CC-930
Catalog No.:BCC1459
CAS No.:899805-25-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 21736-83-4 | SDF | Download SDF |
| PubChem ID | 64740 | Appearance | Powder |
| Formula | C14H26Cl2N2O7 | M.Wt | 405.27 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : ≥ 100 mg/mL (246.75 mM) *"≥" means soluble, but saturation unknown. | ||
| SMILES | CC1CC(=O)C2(C(O1)OC3C(C(C(C(C3O2)NC)O)NC)O)O.Cl.Cl | ||
| Standard InChIKey | FOGDPGQSHLLYIK-XYQGXRRISA-N | ||
| Standard InChI | InChI=1S/C14H24N2O7.2ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;/m1../s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.
Target: Antibacterial
Spectinomycin is an antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. Spectinomycin binds to the 30S subunit of the bacterial ribosome and interrupts protein synthesis. One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida [1]. It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. A resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. Furthermore, Spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene Spcr [2]. References: | |||||
Spectinomycin dihydrochloride Dilution Calculator
Spectinomycin dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4675 mL | 12.3375 mL | 24.6749 mL | 49.3498 mL | 61.6873 mL |
| 5 mM | 0.4935 mL | 2.4675 mL | 4.935 mL | 9.87 mL | 12.3375 mL |
| 10 mM | 0.2467 mL | 1.2337 mL | 2.4675 mL | 4.935 mL | 6.1687 mL |
| 50 mM | 0.0493 mL | 0.2467 mL | 0.4935 mL | 0.987 mL | 1.2337 mL |
| 100 mM | 0.0247 mL | 0.1234 mL | 0.2467 mL | 0.4935 mL | 0.6169 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Spectinomycin Dihydrochloride is a new parenteral antibiotic prepared from Streptomyces spectabilis.
- Aristoliukine B
Catalog No.:BCN8096
CAS No.:217310-32-2
- PD 173212
Catalog No.:BCC7706
CAS No.:217171-01-2
- Etifoxine
Catalog No.:BCC1560
CAS No.:21715-46-8
- BCX 1470 methanesulfonate
Catalog No.:BCC1414
CAS No.:217099-44-0
- BCX 1470
Catalog No.:BCC1413
CAS No.:217099-43-9
- Hugorosenone
Catalog No.:BCN3776
CAS No.:217096-49-6
- Esomeprazole Magnesium trihydrate
Catalog No.:BCC1559
CAS No.:217087-09-7
- [Pyr1]-Apelin-13
Catalog No.:BCC7358
CAS No.:217082-60-5
- Apelin-17 (human, bovine)
Catalog No.:BCC5959
CAS No.:217082-57-0
- WB 4101 hydrochloride
Catalog No.:BCC6858
CAS No.:2170-58-3
- 15-Epi-Danshenol-A
Catalog No.:BCN3146
CAS No.:216987-13-2
- Shyobunone
Catalog No.:BCN4930
CAS No.:21698-44-2
- 5-O-Demethylnobiletin
Catalog No.:BCN2958
CAS No.:2174-59-6
- 5-Methoxyresorcinol
Catalog No.:BCN6904
CAS No.:2174-64-3
- SB 268262
Catalog No.:BCC7916
CAS No.:217438-17-0
- (±)-J 113397
Catalog No.:BCC7423
CAS No.:217461-40-0
- 1-Hydroxy-2-oxopomolic acid
Catalog No.:BCN4931
CAS No.:217466-37-0
- Lucidumol A
Catalog No.:BCN8270
CAS No.:217476-73-8
- L-803,087 trifluoroacetate
Catalog No.:BCC7220
CAS No.:217480-26-7
- L-817,818
Catalog No.:BCC7221
CAS No.:217480-27-8
- Tulathromycin A
Catalog No.:BCC2019
CAS No.:217500-96-4
- Cyclo(Tyr-Val)
Catalog No.:BCN2413
CAS No.:21754-25-6
- Cyclo(Ala-Tyr)
Catalog No.:BCN2412
CAS No.:21754-26-7
- Taxoquinone
Catalog No.:BCN6660
CAS No.:21764-41-0
HPLC-ELSD analysis of spectinomycin dihydrochloride and its impurities.[Pubmed:21710577]
J Sep Sci. 2011 Aug;34(15):1811-9.
A simple, rapid and reliable reversed-phase ion-pair chromatography method by HPLC coupled to an evaporative light scattering detector (ELSD) has been developed to simultaneously determine chloride, spectinomycin and its related substances in a sample. The column was a TSKgel ODS-100V. The mobile phase was ACN/aqueous solution of 15 mM ammonium acetate adjusted with TFA to pH 3.0 (2:98 v/v), in an isocratic mode. The drift tube temperature was set at 50 degrees C and the nebulizing gas flow rate of air was 3.5 L/min for ELSD detection. Almost all of the reported degradation compounds of spectinomycin such as actinamine, actinospectinoic acid and biosynthesis intermediates such as dihydrospectinomycin diastereoisomers were baseline separated. MS was utilized for the identification of spectinomycin and its seven related substances. The method for the assay of spectinomycin was successfully validated with respect to accuracy, precision (RSD less than 2%), linearity (throughout the linear range 0.025-3 mg/mL, r=0.9993), sensitivity (LOD: 100 ng on column) and robustness. The experimental results demonstrated that the simultaneous determination of chloride, spectinomycin and related substances is feasible in a single run, which suggests applicability in routine assays.
Determination of spectinomycin dihydrochloride by liquid chromatography with electrochemical detection.[Pubmed:2977438]
Pharm Res. 1988 Oct;5(10):664-7.
Spectinomycin dihydrochloride is determined by liquid chromatography with electrochemical detection. The drug is chromatographed on a reverse-phase Nucleosil C18 column using an eluent containing 0.02 M sodium citrate and 0.0015 M octyl sodium sulfate (pH 6.10 with perchloric acid) and acetonitrile (100:4). Detection is performed using a coulometric detector (porous carbon working electrode) at +0.85 V. The drug and primary degradation product are detectable. Detector response is linear to at least 20 micrograms/ml, which is four times the assay level. The procedure has relative standard deviations of +/- 1.21 to +/- 2.72% for three lots of bulk drug. Sensitivity is greater than 0.1 microgram/ml of spectinomycin (5 ng on column). Repeatability at this level is +/- 4.94%.
