1-Hydroxy-2-oxopomolic acidCAS# 217466-37-0 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 217466-37-0 | SDF | Download SDF |
| PubChem ID | 10625284 | Appearance | Powder |
| Formula | C30H46O6 | M.Wt | 502.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1R,2R,4aS,6aS,6aS,6bR,8aS,10R,12S,12aR,14bS)-1,10,12-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-11-oxo-3,4,5,6,6a,7,8,8a,10,12,13,14b-dodecahydro-2H-picene-4a-carboxylic acid | ||
| SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(C(C(=O)C(C5(C)C)O)O)C)C)C2C1(C)O)C)C(=O)O | ||
| Standard InChIKey | VBLIMTVKFVIDFU-PAZRJNPVSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Agrimonia pilosa
| Description | 1. 1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression. |
| Targets | PPAR | GLUT | Fatty Acid Synthase |
1-Hydroxy-2-oxopomolic acid Dilution Calculator
1-Hydroxy-2-oxopomolic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9893 mL | 9.9463 mL | 19.8926 mL | 39.7852 mL | 49.7315 mL |
| 5 mM | 0.3979 mL | 1.9893 mL | 3.9785 mL | 7.957 mL | 9.9463 mL |
| 10 mM | 0.1989 mL | 0.9946 mL | 1.9893 mL | 3.9785 mL | 4.9731 mL |
| 50 mM | 0.0398 mL | 0.1989 mL | 0.3979 mL | 0.7957 mL | 0.9946 mL |
| 100 mM | 0.0199 mL | 0.0995 mL | 0.1989 mL | 0.3979 mL | 0.4973 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- (±)-J 113397
Catalog No.:BCC7423
CAS No.:217461-40-0
- SB 268262
Catalog No.:BCC7916
CAS No.:217438-17-0
- 5-Methoxyresorcinol
Catalog No.:BCN6904
CAS No.:2174-64-3
- 5-O-Demethylnobiletin
Catalog No.:BCN2958
CAS No.:2174-59-6
- Spectinomycin dihydrochloride
Catalog No.:BCC5166
CAS No.:21736-83-4
- Aristoliukine B
Catalog No.:BCN8096
CAS No.:217310-32-2
- PD 173212
Catalog No.:BCC7706
CAS No.:217171-01-2
- Etifoxine
Catalog No.:BCC1560
CAS No.:21715-46-8
- BCX 1470 methanesulfonate
Catalog No.:BCC1414
CAS No.:217099-44-0
- BCX 1470
Catalog No.:BCC1413
CAS No.:217099-43-9
- Hugorosenone
Catalog No.:BCN3776
CAS No.:217096-49-6
- Esomeprazole Magnesium trihydrate
Catalog No.:BCC1559
CAS No.:217087-09-7
New Products
- Lucidumol A
Catalog No.:BCN8270
CAS No.:217476-73-8
- L-803,087 trifluoroacetate
Catalog No.:BCC7220
CAS No.:217480-26-7
- L-817,818
Catalog No.:BCC7221
CAS No.:217480-27-8
- Tulathromycin A
Catalog No.:BCC2019
CAS No.:217500-96-4
- Cyclo(Tyr-Val)
Catalog No.:BCN2413
CAS No.:21754-25-6
- Cyclo(Ala-Tyr)
Catalog No.:BCN2412
CAS No.:21754-26-7
- Taxoquinone
Catalog No.:BCN6660
CAS No.:21764-41-0
- BX 471
Catalog No.:BCC6029
CAS No.:217645-70-0
- 4-Cadinen-7-ol
Catalog No.:BCN4932
CAS No.:217650-27-6
- H-Asp(OBzl)-OH
Catalog No.:BCC2885
CAS No.:2177-63-1
- 9,16-Dioxo-10,12,14-octadecatrienoic acid
Catalog No.:BCN1490
CAS No.:217810-46-3
- Curcolonol
Catalog No.:BCN3558
CAS No.:217817-09-9
1beta-Hydroxy-2-oxopomolic acid isolated from Agrimonia pilosa extract inhibits adipogenesis in 3T3-L1 cells.[Pubmed:22687396]
Biol Pharm Bull. 2012;35(5):643-9.
In order to determine anti-adipogenic effect, this study investigated 1beta-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor gamma (PPARgamma), CCAAT-enhancer-binding protein alpha (C/EBPalpha), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c (ADD1/SREBP1c), resistin, and fatty acid synthase (Fas) in 3T3-L1 preadipocyte. We demonstrated that HOA induced a significant decrease in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, HOA reduced the transcripitional activity of PPARgamma induced by troglitazone, a potent diabetes agent; it also suppressed expression of PPARgamma and C/EBPalpha protein levels. Our data suggest that HOA isolated from Agrimonia pilosa inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARgamma and C/EBPalpha expression.
1-Hydroxy-2-oxopomolic acid,217466-37-0,Natural Products, buy 1-Hydroxy-2-oxopomolic acid , 1-Hydroxy-2-oxopomolic acid supplier , purchase 1-Hydroxy-2-oxopomolic acid , 1-Hydroxy-2-oxopomolic acid cost , 1-Hydroxy-2-oxopomolic acid manufacturer , order 1-Hydroxy-2-oxopomolic acid , high purity 1-Hydroxy-2-oxopomolic acid
