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Tebipenempivoxil

Carbapenem antibiotic CAS# 161715-24-8

Tebipenempivoxil

Catalog No. BCC3861----Order now to get a substantial discount!

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Chemical structure

Tebipenempivoxil

3D structure

Chemical Properties of Tebipenempivoxil

Cas No. 161715-24-8 SDF Download SDF
PubChem ID 9892071 Appearance Powder
Formula C22H31N3O6S2 M.Wt 497.63
Type of Compound N/A Storage Desiccate at -20°C
Synonyms L084
Solubility DMSO : ≥ 150 mg/mL (301.43 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 2,2-dimethylpropanoyloxymethyl (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
SMILES CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)C(C)O
Standard InChIKey SNUDIPVBUUXCDG-QHSBEEBCSA-N
Standard InChI InChI=1S/C22H31N3O6S2/c1-11-15-14(12(2)26)18(27)25(15)16(19(28)30-10-31-20(29)22(3,4)5)17(11)33-13-8-24(9-13)21-23-6-7-32-21/h11-15,26H,6-10H2,1-5H3/t11-,12-,14-,15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tebipenempivoxil

DescriptionTebipenem Pivoxil is a novel oral carbapenem antibiotic. Target: Antibacterial Tebipenem is a broad spectrum orally administered antibiotic, from the carbapenem subgroup of beta-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics. Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form. It has performed well in clinical trials for ear infection and looks likely to be further developed in future [1-3].

References:
[1]. El-Gamal, M.I. and C.H. Oh, Current status of carbapenem antibiotics. Curr Top Med Chem, 2010. 10(18): p. 1882-97. [2]. Fujimoto, K., et al., Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother, 2013. 57(2): p. 697-707. [3]. Kato, K., et al., Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharm, 2010. 7(5): p. 1747-56.

Tebipenempivoxil Dilution Calculator

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Tebipenempivoxil Molarity Calculator

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Preparing Stock Solutions of Tebipenempivoxil

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0095 mL 10.0476 mL 20.0953 mL 40.1905 mL 50.2381 mL
5 mM 0.4019 mL 2.0095 mL 4.0191 mL 8.0381 mL 10.0476 mL
10 mM 0.201 mL 1.0048 mL 2.0095 mL 4.0191 mL 5.0238 mL
50 mM 0.0402 mL 0.201 mL 0.4019 mL 0.8038 mL 1.0048 mL
100 mM 0.0201 mL 0.1005 mL 0.201 mL 0.4019 mL 0.5024 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Tebipenempivoxil

Tebipenem is a broad spectrum orally administered antibiotic, from the carbapenem subgroup of beta-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics.[1][2] Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form.[3] It has performed well in clinical trials for ear infection and looks likely to be further developed in future

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Description

Tebipenem Pivoxil is a novel oral carbapenem antibiotic.

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