Amprenavir (agenerase)HIV-1 protease inhibitor CAS# 161814-49-9 |
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Quality Control & MSDS
3D structure
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| Cas No. | 161814-49-9 | SDF | Download SDF |
| PubChem ID | 65016 | Appearance | Powder |
| Formula | C25H35N3O6S | M.Wt | 505.63 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (197.77 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate | ||
| SMILES | CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)O)S(=O)(=O)C3=CC=C(C=C3)N | ||
| Standard InChIKey | YMARZQAQMVYCKC-OEMFJLHTSA-N | ||
| Standard InChI | InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Amprenavir is an inhibitor of HIV protease with IC50 of 14.6 ng/mL in wild-type HIV isolates. | |||||
| Targets | HIV Protease | |||||
Amprenavir (agenerase) Dilution Calculator
Amprenavir (agenerase) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9777 mL | 9.8887 mL | 19.7773 mL | 39.5546 mL | 49.4433 mL |
| 5 mM | 0.3955 mL | 1.9777 mL | 3.9555 mL | 7.9109 mL | 9.8887 mL |
| 10 mM | 0.1978 mL | 0.9889 mL | 1.9777 mL | 3.9555 mL | 4.9443 mL |
| 50 mM | 0.0396 mL | 0.1978 mL | 0.3955 mL | 0.7911 mL | 0.9889 mL |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1978 mL | 0.3955 mL | 0.4944 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Amprenavir (agenerase), an N,N-disubstituted hydroxyethylamino sulfonamide, is a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that potently inhibits the activity of HIV-1 protease with a value of 50% inhibition concentration IC50 of 0.6 nM and also weakly inhibits HIV-2 protease with IC50 value of 19 nM. Amprenavir binds to the catalytic aspartate residues of the HIV-1 protease and hence inhibits the processing of the gag and gag-pol polyprotein precursors, which cleave to yield structural proteins and replication enzymes of HIV, resulting in immature and noninfectious viral particles. Amprenavir has been effectively used for the treatment of HIV disease in patients with primary HIV infection.
Reference
Fung HB, Kirschenbaum HL, Hameed R. Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. Clin Ther. 2000 May;22(5):549-72.
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Amprenavir (AGENERASE) oral solution: warning for some patients.[Pubmed:12870457]
AIDS Treat News. 2000 May 5;(342):3.
The oral form of amprenavir, intended for those who cannot use the capsules, could be harmful to some patients because they cannot metabolize large amounts of an ingredient used to dissolve the drug into liquid form.
Amprenavir (VX-478) is a HIV protease inhibitor(Ki=0.6 nM) used to treat HIV infection.
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