Tirotundin 3-O-methyl etherCAS# 1454840-36-8 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 1454840-36-8 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C20H30O6 | M.Wt | 366.45 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Tirotundin 3-O-methyl ether Dilution Calculator
Tirotundin 3-O-methyl ether Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7289 mL | 13.6444 mL | 27.2889 mL | 54.5777 mL | 68.2221 mL |
| 5 mM | 0.5458 mL | 2.7289 mL | 5.4578 mL | 10.9155 mL | 13.6444 mL |
| 10 mM | 0.2729 mL | 1.3644 mL | 2.7289 mL | 5.4578 mL | 6.8222 mL |
| 50 mM | 0.0546 mL | 0.2729 mL | 0.5458 mL | 1.0916 mL | 1.3644 mL |
| 100 mM | 0.0273 mL | 0.1364 mL | 0.2729 mL | 0.5458 mL | 0.6822 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vitro leishmanicidal activities of sesquiterpene lactones from Tithonia diversifolia against Leishmania braziliensis promastigotes and amastigotes.[Pubmed:24830711]
Molecules. 2014 May 14;19(5):6070-9.
Natural compounds represent a rich and promising source of novel, biologically active chemical entities for treating leishmaniasis. Sesquiterpene lactones are a recognized class of terpenoids with a wide spectrum of biological activities, including activity against Leishmania spp. In this work, a sesquiterpene lactone-rich preparation-a leaf rinse extract (LRE) from Tithonia diversifolia-was tested against promastigote forms of L. braziliensis. The results revealed that the LRE is a rich source of potent leishmanicidal compounds, with an LD50 value 1.5 +/- 0.50 microg.mL-1. Therefore, eight sesquiterpene lactones from the LRE were initially investigated against promastigote forms of L. braziliensis. One of them did not present any significant leishmanicidal effect (LD50 > 50 microg.mL-1). Another had a cytotoxic effect against macrophages (4.5 microg.mL-1). The five leishmanicidal compounds with the highest level of selectivity were further evaluated against intracellular parasites (amastigotes) using peritoneal macrophages. Tirotundin 3-O-methyl ether, tagitinin F, and a guaianolide reduced the internalization of parasites after 48 h, in comparison with the negative control. This is the first report on sesquiterpene lactones that have potent leishmanicidal effects on both developmental stages of L. braziliensis.
