TryptanthrineCAS# 13220-57-0 |
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| Cas No. | 13220-57-0 | SDF | Download SDF |
| PubChem ID | 73549 | Appearance | Yellow powder |
| Formula | C15H8N2O2 | M.Wt | 248.2 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | Couroupitine A | ||
| Solubility | Sparingly soluble in DMSO | ||
| Chemical Name | indolo[2,1-b]quinazoline-6,12-dione | ||
| SMILES | C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2 | ||
| Standard InChIKey | VQQVWGVXDIPORV-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The leaves of Strobilanthes cusia
| Description | Tryptanthrin shows antimycobacterial and antifungal activity as well as anti-proliferative activity. | |||||
Tryptanthrine Dilution Calculator
Tryptanthrine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.029 mL | 20.145 mL | 40.2901 mL | 80.5802 mL | 100.7252 mL |
| 5 mM | 0.8058 mL | 4.029 mL | 8.058 mL | 16.116 mL | 20.145 mL |
| 10 mM | 0.4029 mL | 2.0145 mL | 4.029 mL | 8.058 mL | 10.0725 mL |
| 50 mM | 0.0806 mL | 0.4029 mL | 0.8058 mL | 1.6116 mL | 2.0145 mL |
| 100 mM | 0.0403 mL | 0.2015 mL | 0.4029 mL | 0.8058 mL | 1.0073 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences.[Pubmed:32557405]
Nat Prod Bioprospect. 2020 Oct;10(5):297-306.
SARS-CoV-2 (2019-nCoV) emerged in 2019 and proliferated rapidly across the globe. Scientists are attempting to investigate antivirals specific to COVID-19 treatment. The 2019-nCoV and SARS-CoV utilize the same receptor of the host which is COVID-19 of the main protease (Mpro).COVID-19 caused by SARS-CoV-2 is burdensome to overcome by presently acquired antiviral candidates. So the objective and purpose of this work was to investigate the plants with reported potential antiviral activity. With the aid of in silico techniques such as molecular docking and druggability studies, we have proposed several natural active compounds including glycyrrhizin, bicylogermecrene, Tryptanthrine, beta-sitosterol, indirubin, indican, indigo, hesperetin, crysophanic acid, rhein, berberine and beta-caryophyllene which can be encountered as potential herbal candidate exhibiting anti-viral activity against SARS-CoV-2. Promising docking outcomes have been executed which evidenced the worthy of these selected herbal remedies for future drug development to combat coronavirus disease.
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