BIX 01294 TrihydrochlorideCAS# 1392399-03-9 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1392399-03-9 | SDF | Download SDF |
| PubChem ID | 46945860 | Appearance | Powder |
| Formula | C28H38N6O2.3HCl | M.Wt | 600.02 |
| Type of Compound | Inhibitors | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine;trihydrochloride | ||
| SMILES | CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl | ||
| Standard InChIKey | FMURUEPQXKJIPS-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
BIX 01294 Trihydrochloride Dilution Calculator
BIX 01294 Trihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.6666 mL | 8.3331 mL | 16.6661 mL | 33.3322 mL | 41.6653 mL |
| 5 mM | 0.3333 mL | 1.6666 mL | 3.3332 mL | 6.6664 mL | 8.3331 mL |
| 10 mM | 0.1667 mL | 0.8333 mL | 1.6666 mL | 3.3332 mL | 4.1665 mL |
| 50 mM | 0.0333 mL | 0.1667 mL | 0.3333 mL | 0.6666 mL | 0.8333 mL |
| 100 mM | 0.0167 mL | 0.0833 mL | 0.1667 mL | 0.3333 mL | 0.4167 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Teupolioside
Catalog No.:BCN9833
CAS No.:143617-02-1
- Ethyl caproate
Catalog No.:BCN9832
CAS No.:123-66-0
- 28-Homobrassinolide
Catalog No.:BCN9831
CAS No.:82373-95-3
- Urushiol (15:1)
Catalog No.:BCN9830
CAS No.:35237-02-6
- 4,4'-Dimethoxychalcone
Catalog No.:BCN9829
CAS No.:2373-89-9
- Picrotoxinin
Catalog No.:BCN9828
CAS No.:17617-45-7
- 6-Hydroxyflavone
Catalog No.:BCN9827
CAS No.:6665-83-4
- Vaccarin E
Catalog No.:BCN9826
CAS No.:2252345-81-4
- Grayanotoxin I
Catalog No.:BCN9825
CAS No.:4720-09-6
- Acetic acid hexyl ester
Catalog No.:BCN9824
CAS No.:142-92-7
- Morindin
Catalog No.:BCN9823
CAS No.:60450-21-7
- Eclalbasaponin II
Catalog No.:BCN9822
CAS No.:78285-90-3
- 6,7-Bis(benzyloxy)coumarin
Catalog No.:BCN9835
CAS No.:909-84-2
- Urushiol (15:2)
Catalog No.:BCN9836
CAS No.:83258-37-1
- Isobutyl acetate
Catalog No.:BCN9837
CAS No.:110-19-0
- 5-Methoxyflavone
Catalog No.:BCN9838
CAS No.:42079-78-7
- Pilocarpine
Catalog No.:BCN9839
CAS No.:92-13-7
- Sutherlandioside D
Catalog No.:BCN9840
CAS No.:1055329-49-1
- Bletilol B
Catalog No.:BCN9841
CAS No.:147235-17-4
- Butyl acetate
Catalog No.:BCN9842
CAS No.:123-86-4
- Eugenol benzoate
Catalog No.:BCN9843
CAS No.:531-26-0
- Tryptanthrine
Catalog No.:BCN9844
CAS No.:13220-57-0
- 9-Hydroxy-O-senecioyl-8,9-dihydrooroselol
Catalog No.:BCN9845
CAS No.:31456-63-0
- Vitexin 7-glucoside
Catalog No.:BCN9846
CAS No.:35109-95-6
G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress.[Pubmed:32256958]
Oxid Med Cell Longev. 2020 Mar 12;2020:6983268.
Background: G9a, a well-known methyltransferase, plays a vital role in biological processes. However, its role in corneal neovascularization (CoNV) remains unclear. Methods. In vitro and in vivo models were assessed in hypoxia-stimulated angiogenesis and in a mouse model of alkali burn-induced CoNV. Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic conditions and different reoxygenation times to identify the molecular mechanisms involved in this process. Results: In this study, we found that G9a was positively related to corneal alkali burn-induced injury. Inhibition of G9a with BIX 01294 (BIX) alleviated corneal injury, including oxidative stress and neovascularization in vivo models were assessed in hypoxia-stimulated angiogenesis and in a mouse model of alkali burn-induced CoNV. Human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic conditions and different reoxygenation times to identify the molecular mechanisms involved in this process.
H3K9 Demethylation-Induced R-Loop Accumulation Is Linked to Disorganized Nucleoli.[Pubmed:32117455]
Front Genet. 2020 Feb 6;11:43.
The nucleolar structure and integrity are important for a range of cellular functions of the nucleoli. It has been shown that cells lacking histone H3 Lysine 9 (H3K9) methylation form fragmented nucleoli. However, the molecular mechanism involved remains poorly understood. Here, we present evidence suggesting that loss of H3K9 dimethylation (H3K9me2) triggers R-loop accumulation at the rDNA locus, which further leads to the multilobed nucleoli. We reveal that suppression of H3K9 methyltransferase G9a by the inhibitor BIX 01294 causes R-loop accumulation at the rDNA region as well as inducing formation of multiple nucleoli. SiRNA-mediated knockdown of RNase H1 which can hydrolyze the RNA chain in R-loops causes an increase in R-loop formation, which in turn results in multiple nucleoli in one nucleus, whereas H3K9me2 levels are not affected by R-loop accumulation. Inhibition of RNA polymerase I transcription elongation by small molecule inhibitors induces a substantial decrease in H3K9me2 levels, accumulation of R-loops at rDNA sites, and nucleolus fragmentation. These results provide a mechanistic insight into the role of H3K9me2 in the structural integrity and organization of nucleoli via regulating R-loop accumulation.
