WAY 267464 dihydrochloridePotent non-peptide oxytocin receptor agonist CAS# 1432043-31-6 |
Quality Control & MSDS
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| Cas No. | 1432043-31-6 | SDF | Download SDF |
| PubChem ID | 71555165 | Appearance | Powder |
| Formula | C32H35N7O4.2HCl | M.Wt | 654.59 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 80 mM in DMSO and to 5 mM in water | ||
| Chemical Name | 4-[(3,5-dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-2,4-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamide;dihydrochloride | ||
| SMILES | CC1=C(C=CC(=C1)C(=O)N2CC3=CNN(C3=NC4=CC=CC=C42)C)CNC(=O)N5CCN(CC5)CC6=CC(=CC(=C6)O)O.Cl.Cl | ||
| Standard InChIKey | OFWMUAWQQXSNJI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C32H35N7O4.2ClH/c1-21-13-23(31(42)39-20-25-18-34-36(2)30(25)35-28-5-3-4-6-29(28)39)7-8-24(21)17-33-32(43)38-11-9-37(10-12-38)19-22-14-26(40)16-27(41)15-22;;/h3-8,13-16,18,34,40-41H,9-12,17,19-20H2,1-2H3,(H,33,43);2*1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia. |
WAY 267464 dihydrochloride Dilution Calculator
WAY 267464 dihydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5277 mL | 7.6384 mL | 15.2767 mL | 30.5535 mL | 38.1918 mL |
| 5 mM | 0.3055 mL | 1.5277 mL | 3.0553 mL | 6.1107 mL | 7.6384 mL |
| 10 mM | 0.1528 mL | 0.7638 mL | 1.5277 mL | 3.0553 mL | 3.8192 mL |
| 50 mM | 0.0306 mL | 0.1528 mL | 0.3055 mL | 0.6111 mL | 0.7638 mL |
| 100 mM | 0.0153 mL | 0.0764 mL | 0.1528 mL | 0.3055 mL | 0.3819 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist.[Pubmed:19615387]
Neuropharmacology. 2010 Jan;58(1):69-77.
The widely reported effects of oxytocin (OT) on CNS function has generated considerable interest in the therapeutic potential for targeting this system for a variety of human psychiatric diseases, including anxiety disorders, autism, schizophrenia, and depression. The utility of synthetic OT, as both a research tool and neurotherapeutic, is limited by the physiochemical properties inherent in most neuropeptides, notably its short half-life and poor blood brain barrier penetration. Subsequently, the discovery and development of non-peptide molecules that act as selective agonists of the oxytocin receptor (OTR) has been an important goal of the field. In this study, we report the receptor and behavioral pharmacology of WAY-267464, a first generation small-molecule OTR agonist. WAY-267464 is a high-affinity, potent, and selective (vs. V1a, V2, V1b) agonist of the OTR. In assays measuring both behavioral (four-plate test, elevated zero maze) and autonomic (stress-induced hyperthermia) parameters of the anxiety response, WAY-267464 exhibits an anxiolytic-like profile similar to OT. We have demonstrated that the anxiolytic-like profile of WAY-267464 is mediated through central sites of action. WAY-267464 also significantly reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine, similar to the antipsychotic-like effects previously reported for OT. Interestingly, in the mouse tail suspension test, WAY-267464 failed to produce changes in immobility that are seen with OT, raising the question of whether the antidepressant-like activity of OT may be working independently of the OTR. A selective OTR antagonist also failed to block the effects of OT on immobility in the TST. The significance of these findings for shaping the clinical development of OTR agonists is discussed.
