Caspase
Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.
Products for Caspase
- Cat.No. Product Name Information/Activity
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BCC2356
AZ 10417808
Selective non-peptide caspase-3 inhibitor
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BCC1137
Z-DEVD-FMK
Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with IC50 of 18 μM.
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BCC1126
Z-VAD-FMK
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.
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BCC1138
Z-VDVAD-FMK
N/A
-
BCC2358
Ac-IEPD-AFC
Ac-IEPD-AFC (IEPD) is a substrate of Granzyme B.
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BCC2359
Ac-LEHD-AFC
210345-03-2
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BCN1552
Cisplatin
Potent pro-apoptotic anticancer agent; activates caspase-3,Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells.
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BCN2318
Gambogic acid
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
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BCC3600
PAC-1
PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.
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BCC2360
PETCM
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells.
