Ac-IEPD-AFCRecognition motif for serine protease granzyme B CAS# 1135417-31-0 |
Related Products
- Amyloid β-Protein (1-15)
Catalog No.:BCC1003
CAS No.:183745-81-5
- Beta-Amyloid (1-11)
Catalog No.:BCC1002
CAS No.:190436-05-6
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1135417-31-0 | SDF | Download SDF |
| PubChem ID | 25108575 | Appearance | Powder |
| Formula | C32H38F3N5O11 | M.Wt | 725.67 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 14.51 mg/ml in DMSO | ||
| Sequence | IEPD (Modifications: Ile-1 = N-Ac-Ile, Asp-4 = Asp-(7-amino-4-trifluoromethyl | ||
| Chemical Name | (4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[(2S)-2-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid | ||
| SMILES | CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F)NC(=O)C | ||
| Standard InChIKey | HWXKKVLJPWMVLL-FGGUPADCSA-N | ||
| Standard InChI | InChI=1S/C32H38F3N5O11/c1-4-15(2)27(36-16(3)41)30(49)38-20(9-10-24(42)43)31(50)40-11-5-6-22(40)29(48)39-21(14-25(44)45)28(47)37-17-7-8-18-19(32(33,34)35)13-26(46)51-23(18)12-17/h7-8,12-13,15,20-22,27H,4-6,9-11,14H2,1-3H3,(H,36,41)(H,37,47)(H,38,49)(H,39,48)(H,42,43)(H,44,45)/t15-,20-,21-,22-,27-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Peptide sequence shown to be preferred recognition motif for the serine protease granzyme B. Fluorogenic substrate. |
Ac-IEPD-AFC Dilution Calculator
Ac-IEPD-AFC Molarity Calculator
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
Featured Products
- 25(S)-Hydroxyprotopanaxatriol
Catalog No.:BCN2495
CAS No.:113539-03-0
- 6-Bnz-cAMP sodium salt
Catalog No.:BCC8043
CAS No.:1135306-29-4
- Altanserin hydrochloride
Catalog No.:BCC7183
CAS No.:1135280-78-2
- KN-92 phosphate
Catalog No.:BCC1682
CAS No.:1135280-28-2
- 3'-Fluorobenzylspiperone maleate
Catalog No.:BCC6752
CAS No.:1135278-61-3
- CGP 78608 hydrochloride
Catalog No.:BCC7087
CAS No.:1135278-54-4
- SR 59230A hydrochloride
Catalog No.:BCC7094
CAS No.:1135278-41-9
- VU 0255035
Catalog No.:BCC7766
CAS No.:1135243-19-4
- VU 0357017 hydrochloride
Catalog No.:BCC7907
CAS No.:1135242-13-5
- Tracazolate hydrochloride
Catalog No.:BCC7115
CAS No.:1135210-68-2
- Moxidectin
Catalog No.:BCC5309
CAS No.:113507-06-5
- Ferulic acid
Catalog No.:BCN5948
CAS No.:1135-24-6
New Products
- Magnoloside A
Catalog No.:BCN6013
CAS No.:113557-95-2
- 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid
Catalog No.:BCN1615
CAS No.:113558-03-5
- Ikarisoside F
Catalog No.:BCN2284
CAS No.:113558-14-8
- Baohuoside I
Catalog No.:BCN5350
CAS No.:113558-15-9
- E-4031 dihydrochloride
Catalog No.:BCC7182
CAS No.:113559-13-0
- Q-VD-OPh hydrate
Catalog No.:BCC1125
CAS No.:1135695-98-5
- Tigecycline mesylate
Catalog No.:BCC4229
CAS No.:1135871-27-0
- Orbifloxacin
Catalog No.:BCC4689
CAS No.:113617-63-3
- 6beta-(Hexa-2,4-dienoyloxy)-9alpha,12-dihydroxydrimenol
Catalog No.:BCN7277
CAS No.:1136245-81-2
- Metasequoic acid A
Catalog No.:BCN6652
CAS No.:113626-22-5
- Stigmast-4-ene-3,6-diol
Catalog No.:BCN6014
CAS No.:113626-76-9
- IDE 2
Catalog No.:BCC6099
CAS No.:1136466-93-7
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.[Pubmed:9218414]
J Biol Chem. 1997 Jul 18;272(29):17907-11.
There is compelling evidence that members of the caspase (interleukin-1beta converting enzyme/CED-3) family of cysteine proteases and the cytotoxic lymphocyte-derived serine protease granzyme B play essential roles in mammalian apoptosis. Here we use a novel method employing a positional scanning substrate combinatorial library to rigorously define their individual specificities. The results divide these proteases into three distinct groups and suggest that several have redundant functions. The specificity of caspases 2, 3, and 7 and Caenorhabditis elegans CED-3 (DEXD) suggests that all of these enzymes function to incapacitate essential homeostatic pathways during the effector phase of apoptosis. In contrast, the optimal sequence for caspases 6, 8, and 9 and granzyme B ((I/L/V)EXD) resembles activation sites in effector caspase proenzymes, consistent with a role for these enzymes as upstream components in a proteolytic cascade that amplifies the death signal.
Ac-IEPD-AFC (IEPD) is a substrate of Granzyme B.
Ac-IEPD-AFC,1135417-31-0,Natural Products,Caspase, buy Ac-IEPD-AFC , Ac-IEPD-AFC supplier , purchase Ac-IEPD-AFC , Ac-IEPD-AFC cost , Ac-IEPD-AFC manufacturer , order Ac-IEPD-AFC , high purity Ac-IEPD-AFC
