Ikarisoside FCAS# 113558-14-8 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 113558-14-8 | SDF | Download SDF |
| PubChem ID | 5318413 | Appearance | Yellow powder |
| Formula | C31H36O14 | M.Wt | 632.62 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Synonyms | Ikarisoside-F; Icarisoside-F | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-[(2S,3R,4S,5R)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one | ||
| SMILES | CC1C(C(C(C(O1)OC2C(C(COC2OC3=C(OC4=C(C3=O)C(=CC(=C4CC=C(C)C)O)O)C5=CC=C(C=C5)O)O)O)O)O)O | ||
| Standard InChIKey | JFEVWNOGUFYCOV-NPFMWIEOSA-N | ||
| Standard InChI | InChI=1S/C31H36O14/c1-12(2)4-9-16-17(33)10-18(34)20-23(38)28(26(43-27(16)20)14-5-7-15(32)8-6-14)44-31-29(22(37)19(35)11-41-31)45-30-25(40)24(39)21(36)13(3)42-30/h4-8,10,13,19,21-22,24-25,29-37,39-40H,9,11H2,1-3H3/t13-,19+,21-,22-,24+,25+,29+,30-,31-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. |
Ikarisoside F Dilution Calculator
Ikarisoside F Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5807 mL | 7.9036 mL | 15.8073 mL | 31.6146 mL | 39.5182 mL |
| 5 mM | 0.3161 mL | 1.5807 mL | 3.1615 mL | 6.3229 mL | 7.9036 mL |
| 10 mM | 0.1581 mL | 0.7904 mL | 1.5807 mL | 3.1615 mL | 3.9518 mL |
| 50 mM | 0.0316 mL | 0.1581 mL | 0.3161 mL | 0.6323 mL | 0.7904 mL |
| 100 mM | 0.0158 mL | 0.079 mL | 0.1581 mL | 0.3161 mL | 0.3952 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Ikarisoside F is a flavonol glycoside from Vancouveria hexandra; could bind to AdoHcy hydrolase.
References:
[1]. Mizuno M, et al. Two flavonol glycosides from Vancouveria hexandra. Phytochemistry. 1992 Jan;31(1):297-9.
[2]. Zhang X, et al. Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Life Sci. 2005 Nov 26;78(2):180-6.
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Two flavonol glycosides from Vancouveria hexandra.[Pubmed:1367883]
Phytochemistry. 1992 Jan;31(1):297-9.
In addition to two known glycosides, Ikarisoside F and epimedin A, two new glycosides of a flavonol with a gamma, gamma-dimethylallyl group were isolated from the underground and the aerial parts of Vancouveria hexandra. The structures were determined to be des-O-methylanhydroicaritin 3,7-diglucoside and anhydroicaritin 3-glucosyl (1----3)rhamnoside-7-glucoside by means of spectral analysis.
Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation.[Pubmed:16125732]
Life Sci. 2005 Nov 26;78(2):180-6.
In the present paper, the inhibitory effect of Epimedium extract on the activity of S-adenosyl-L-homocysteine (AdoHcy) Hydrolase was studied. The results showed that Epimedium extract inhibited the activity of recombinant human AdoHcy hydrolase in a dose-dependent manner. This inhibitory effect was also observed in hepatic cell line 7701 and hepatoma HepG2, however, the effect in 7701 cells was more potent than in HepG2 cells. The extract could significantly reduce AdoMet/AdoHcy ratio in 7701 cells in a dose-dependent manner, suggesting reduced biomethylation level in 7701 cells. In contrast, it resulted in elevated AdoMet/AdoHcy ratio in the HepG2 cells. The result of MALDI-MS assay indicated that epimedin A and Ikarisoside F from the extract could bind to AdoHcy hydrolase. The present data suggested that Epimedium extract could inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. These results will provide new clues to the mechanisms of Epimedium in curing of cardiovascular disease and regulating tumor cell growth.
