Growth Factors and Cytokines

Growth factors are extracellular polypeptides that bind to cell surface receptors and trigger intracellular signaling cascades, resulting in cell proliferation and/or differentiation. Growth factors can be versatile, stimulating growth in a variety of different cell types (for example IGF-1), whilst others are cell-specific (for example erythropoietin acts solely on erythrocytes).

Growth Factors and Cytokines Products Targets

Products for Growth Factors and Cytokines - Page 6

Cat.No. Product Name Information/Activity
BCC5568 PF-06463922 Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib has anticancer activity.
BCC2520 AEE788 (NVP-AEE788) AEE788 is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively.
BCC1051 AG-18 Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
BCC2193 AG-490 AG-490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
BCC6722 AG 494 Potent EGFR-kinase inhibitor
BCC6721 AG 555 AG 555, a potent antiretroviral drug, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation.
BCC6720 AG 556 EGFR-kinase inhibitor
BCC7113 AG 825 AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC50 of 0.35 μM. AG-825 displays anti-cancer activity. AG825 significantly accelerates apoptosis of human neutrophils. AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development.
BCC4514 Tyrphostin AG 879 Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity.
BCC6667 AG 99 (E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor.