Abl Kinase
The Abl family of non-receptor tyrosine kinases includes c-Abl (Abelson tyrosine kinase) and Arg (Abl2) subtypes. c-Abl is localized at many subcellular sites including the nucleus, cytoplasm, mitochondria and endoplasmic reticulum, where it interacts with several proteins.
Products for Abl Kinase
- Cat.No. Product Name Information/Activity
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BCC3890
Adaphostin
p210<sup>bcr/abl</sup> kinase inhibitor
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BCC2522
Ponatinib (AP24534)
Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
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BCC1167
Bosutinib (SKI-606)
Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively.
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BCC3891
GNF 2
GNF-2 is a highly selective non-ATP competitive inhibitor of oncogenic Bcr-Abl activity (IC50 = 0.14 μM).
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BCC3892
GNF 5
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).
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BCC1115
Imatinib Mesylate (STI571)
Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
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BCC3893
1-Naphthyl PP1
1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).
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BCC3894
PD 180970
p210<sup>Bcr/Abl</sup> kinase inhibitor; also inhibits c-Src and KIT
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BCC3895
PPY A
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
