Aurora Kinase
Aurora kinases are a family of three highly homologous serine/threonine kinases that play a critical role in regulating many of the processes that are pivotal to mitosis. Each of the isoforms, Aurora A, Aurora B and Aurora C, has a different function in the control of mitosis.
Products for Aurora Kinase
- Cat.No. Product Name Information/Activity
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BCC2188
CCT137690
CCT 137690 is a potent and orally available aurora kinase inhibitor with IC50s of 15, 25, and 19 nM for aurora A, B and C, respectively.
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BCC2174
Hesperadin
Hesperadin is an ATP-competitive inhibitor of aurora B kinase with an IC50 of 250 nM.
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BCC2184
PF-03814735
PF-03814735 is a potent, orally available and reversible aurora A and aurora B inhibitor with IC50s of 0.8 and 0.5 nM, respectively.
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BCC2177
SNS-314 Mesylate
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
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BCC2418
TC-A 2317 hydrochloride
Potent, selective Aurora kinase A inhibitor
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BCC2182
Aurora A Inhibitor I
Potent and selective Aurora kinase A inhibitor,Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.
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BCC2167
VX-680 (MK-0457,Tozasertib)
Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.
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BCC2169
ZM 447439
ZM-447439 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.
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BCN2483
Ginkgolic acid C15:0
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.
