TC-A 2317 hydrochlorideAurora kinase A inhibitor,potent and selective CAS# 1245907-03-2 |
- Nadifloxacin
Catalog No.:BCC4804
CAS No.:124858-35-1
- Calcipotriol monohydrate
Catalog No.:BCC1445
CAS No.:147657-22-5
- Halobetasol Propionate
Catalog No.:BCC4664
CAS No.:66852-54-8
- Dihydroartemisinin
Catalog No.:BCN6264
CAS No.:71939-50-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1245907-03-2 | SDF | Download SDF |
PubChem ID | 46911725 | Appearance | Powder |
Formula | C19H29ClN6O | M.Wt | 392.93 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | ||
Chemical Name | 2-[(6-hydroxy-6-methylheptan-2-yl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile;hydrochloride | ||
SMILES | CC1=CC(=NC(=C1C#N)NC(C)CCCC(C)(C)O)NC2=NNC(=C2)C.Cl | ||
Standard InChIKey | DXVATYHPJJPMIN-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C19H28N6O.ClH/c1-12-9-16(22-17-10-14(3)24-25-17)23-18(15(12)11-20)21-13(2)7-6-8-19(4,5)26;/h9-10,13,26H,6-8H2,1-5H3,(H3,21,22,23,24,25);1H | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity. |
TC-A 2317 hydrochloride Dilution Calculator
TC-A 2317 hydrochloride Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.545 mL | 12.7249 mL | 25.4498 mL | 50.8997 mL | 63.6246 mL |
5 mM | 0.509 mL | 2.545 mL | 5.09 mL | 10.1799 mL | 12.7249 mL |
10 mM | 0.2545 mL | 1.2725 mL | 2.545 mL | 5.09 mL | 6.3625 mL |
50 mM | 0.0509 mL | 0.2545 mL | 0.509 mL | 1.018 mL | 1.2725 mL |
100 mM | 0.0254 mL | 0.1272 mL | 0.2545 mL | 0.509 mL | 0.6362 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
TC-A-2317 hydrochloride is a potent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.
- Daidzin 6'-O-malonate
Catalog No.:BCN8245
CAS No.:124590-31-4
- Brain natriuretic peptide (1-32) (human)
Catalog No.:BCC6034
CAS No.:124584-08-3
- ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside
Catalog No.:BCN1598
CAS No.:1245636-01-4
- GR 79236
Catalog No.:BCC7215
CAS No.:124555-18-6
- NVP-BGT226
Catalog No.:BCC3827
CAS No.:1245537-68-1
- Glucocorticoid receptor agonist
Catalog No.:BCC1596
CAS No.:1245526-82-2
- PI4KIII beta inhibitor 3
Catalog No.:BCC1310
CAS No.:1245319-54-3
- 16-Oxoalisol A
Catalog No.:BCN3460
CAS No.:124515-98-6
- Retusin
Catalog No.:BCN7794
CAS No.:1245-15-4
- 2,2'-Bicinchoninic acid
Catalog No.:BCC8487
CAS No.:1245-13-2
- 16R-sitsirikine
Catalog No.:BCN3492
CAS No.:1245-00-7
- VU 0364739 hydrochloride
Catalog No.:BCC7875
CAS No.:1244640-48-9
- 2-Methyl-4-(2-methylbutyryl)phloroglucinol
Catalog No.:BCN7175
CAS No.:124598-11-4
- 6-O-Benzoylphlorigidoside B
Catalog No.:BCN6128
CAS No.:1246012-24-7
- 6-O-trans-Cinnamoylphlorigidoside B
Catalog No.:BCN6129
CAS No.:1246012-25-8
- 6-O-trans-p-Coumaroylshanzhiside methyl ester
Catalog No.:BCN1597
CAS No.:1246012-26-9
- 4'-O-trans-p-Coumaroylmussaenoside
Catalog No.:BCN6130
CAS No.:1246012-27-0
- Methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate
Catalog No.:BCN8363
CAS No.:124605-42-1
- VU 0364439
Catalog No.:BCC1239
CAS No.:1246086-78-1
- C3bot (154-182)
Catalog No.:BCC6117
CAS No.:1246280-79-4
- Officinaruminane B
Catalog No.:BCN3594
CAS No.:1246282-67-6
- (-)-Dihydroguaiaretic acid
Catalog No.:BCN8002
CAS No.:124649-78-1
- SR1078
Catalog No.:BCC1963
CAS No.:1246525-60-9
- MPI-0479605
Catalog No.:BCC5347
CAS No.:1246529-32-7
3-Cyano-6-(5-methyl-3-pyrazoloamino)pyridines: selective Aurora A kinase inhibitors.[Pubmed:20573509]
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4709-11.
A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl-3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent selectivity to Aurora B kinase and other 60 kinases, good cell permeability and good PK profile. Therefore compound 6 was effective in antitumor mice model at a dose of 30 mg/kg po qd without decrease of body weight.