Aurora Kinase
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
Products for Aurora Kinase
- Cat.No. Product Name Information
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BCN2483
Ginkgolic acid C15:0 Noncompetitive PCAF/p300 inhibitor
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BCC1393
AZD1152Aurora B kinase inhibitor,highly potent and selective
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BCC1892
ReversineA3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
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BCC1934
SCH-1473759Aurora A/B inhibitor
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BCC2058
XL228IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor
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BCC2166
MLN8237 (Alisertib)Aurora A Kinase inhibitor, Potent and selective
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BCC2167
VX-680 (MK-0457,Tozasertib)High affinity and selective Aurora kinase inhibitor
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BCC2168
Barasertib (AZD1152-HQPA)Aurora Kinase B inhibitor, Potent and selective
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BCC2169
ZM 447439Inhibits Aurora kinase B
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BCC2170
MLN8054Aurora A inhibitor
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BCC2171
JNJ-7706621Potent CDK/Aurora kinase inhibitor
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BCC2173
AT9283Aurora kinase/JAK inhibitor
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BCC2174
HesperadinPotent Aurora kinase B inhibitor
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BCC2175
AMG-900Aurora kinase inhibitor
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BCC2176
MK-5108 (VX-689)Aurora-A kinase inhibitor,highly selective
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BCC2177
SNS-314 MesylatePotent pan-Aurora kinase inhibitor
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BCC2178
PHA-680632Aurora kinase inhibitor,novel and potent
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BCC2180
TAK-901Novel Aurora A/B inhibitor
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BCC2181
CYC116Potent Aurora A/B inhibitor
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BCC2183
GSK1070916Aurora B/C inhibitor
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BCC2184
PF-03814735Aurora kinase A and B inhibitor
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BCC2185
ENMD-2076 L-(+)-Tartaric acidAurora kinases inhibitor
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BCC2186
ENMD-2076Selective Aurora A/Flt3 inhibitor
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BCC2187
CCT129202Aurora kinase inhibitor,ATP-competitive and potent
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BCC2188
CCT137690Potent pan-Aurora kinase inhibitor
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BCC2418
TC-A 2317 hydrochloridePotent, selective Aurora kinase A inhibitor