Aurora Kinase
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
Products for Aurora Kinase
- Cat.No. Product Name Information
- BCN2483 Ginkgolic acid C15:0 Noncompetitive PCAF/p300 inhibitor
- BCC1393 AZD1152Aurora B kinase inhibitor,highly potent and selective
- BCC1892 ReversineA3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
- BCC1934 SCH-1473759Aurora A/B inhibitor
- BCC2058 XL228IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor
- BCC2166 MLN8237 (Alisertib)Aurora A Kinase inhibitor, Potent and selective
- BCC2167 VX-680 (MK-0457,Tozasertib)High affinity and selective Aurora kinase inhibitor
- BCC2168 Barasertib (AZD1152-HQPA)Aurora Kinase B inhibitor, Potent and selective
- BCC2169 ZM 447439Inhibits Aurora kinase B
- BCC2170 MLN8054Aurora A inhibitor
- BCC2171 JNJ-7706621Potent CDK/Aurora kinase inhibitor
- BCC2173 AT9283Aurora kinase/JAK inhibitor
- BCC2174 HesperadinPotent Aurora kinase B inhibitor
- BCC2175 AMG-900Aurora kinase inhibitor
- BCC2176 MK-5108 (VX-689)Aurora-A kinase inhibitor,highly selective
- BCC2177 SNS-314 MesylatePotent pan-Aurora kinase inhibitor
- BCC2178 PHA-680632Aurora kinase inhibitor,novel and potent
- BCC2180 TAK-901Novel Aurora A/B inhibitor
- BCC2181 CYC116Potent Aurora A/B inhibitor
- BCC2183 GSK1070916Aurora B/C inhibitor
- BCC2184 PF-03814735Aurora kinase A and B inhibitor
- BCC2185 ENMD-2076 L-(+)-Tartaric acidAurora kinases inhibitor
- BCC2186 ENMD-2076Selective Aurora A/Flt3 inhibitor
- BCC2187 CCT129202Aurora kinase inhibitor,ATP-competitive and potent
- BCC2188 CCT137690Potent pan-Aurora kinase inhibitor
- BCC2418 TC-A 2317 hydrochloridePotent, selective Aurora kinase A inhibitor