Ginkgolic acid C15:0HAT inhibitor CAS# 16611-84-0 |
- Olprinone
Catalog No.:BCC1820
CAS No.:106730-54-5
- GSK256066 2,2,2-trifluoroacetic acid
Catalog No.:BCC1605
CAS No.:1415560-64-3
- Nortadalafil
Catalog No.:BCC1806
CAS No.:171596-36-4
- Bay 60-7550
Catalog No.:BCC1405
CAS No.:439083-90-6
- Oglemilast
Catalog No.:BCC1817
CAS No.:778576-62-8
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 16611-84-0 | SDF | Download SDF |
PubChem ID | 167551 | Appearance | Powder |
Formula | C22H36O3 | M.Wt | 348.52 |
Type of Compound | Phenols | Storage | Desiccate at -20°C |
Solubility | DMSO : 100 mg/mL (286.93 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) | ||
Chemical Name | 2-hydroxy-6-pentadecylbenzoic acid | ||
SMILES | CCCCCCCCCCCCCCCC1=C(C(=CC=C1)O)C(=O)O | ||
Standard InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C22H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h15,17-18,23H,2-14,16H2,1H3,(H,24,25) | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Kinase Assay | Spectroscopic studies on the interaction of bovine serum albumin with ginkgolic acid: Binding characteristics and structural analysis[Reference: WebLink]Journal of Luminescence Volume 132, Issue 5, May 2012, Pages 1207–1214The interaction between Ginkgolic acid C15:0 and bovine serum albumin (BSA) is investigated by several spectroscopic methodologies. |
Ginkgolic acid C15:0 Dilution Calculator
Ginkgolic acid C15:0 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.8693 mL | 14.3464 mL | 28.6928 mL | 57.3855 mL | 71.7319 mL |
5 mM | 0.5739 mL | 2.8693 mL | 5.7386 mL | 11.4771 mL | 14.3464 mL |
10 mM | 0.2869 mL | 1.4346 mL | 2.8693 mL | 5.7386 mL | 7.1732 mL |
50 mM | 0.0574 mL | 0.2869 mL | 0.5739 mL | 1.1477 mL | 1.4346 mL |
100 mM | 0.0287 mL | 0.1435 mL | 0.2869 mL | 0.5739 mL | 0.7173 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
IC50: Noncompetitively inhibit histone acetyltransferase (HAT) activity in prostate cancer with an IC50 value of about 5.0 M.
Anacardic acid (AA) is commonly regarded as a non-specific HAT inhibitor of p300. Meanwhile, it regulates the activity and expression of several other crucial enzymes including NFκB kinase, lipoxygenase (LOX-1), xanthine oxidase, tyrosinase and ureases. Therefore, this compound exerts anti-oxidation, anti-inflammation and anti-tumor activities in vitro and in vivo. [1]
In vitro: LNCaP, a classical metastatic prostate adenocarcinoma cell line, was adopted to study the effect of AA on cell growth, cycles and apoptosis. It was found that 125 M AA significantly inhibited LNCaP cell proliferation. In addition, the G1/S cell cycles arrest and the apoptosis of LNCaP cell was induced. Further mechanistic study suggested that AA induced cell apoptosis via suppressing p300. [1]
In vivo: Diesel exhaust particle- (DEP-) induced lung inflammation model was established to study the effect of AA on inflammation in mice. Ten days before DEP-instillation stimulation, mice were orally pretreated with 50, 150, or 250 mg/kg of AA for thirty days. All doses of AA ameliorated activities of oxidative enzymes. Moreover, 50 mg/kg of AA significantly decreased the expression level of tumor necrosis factor in lung. [2]
Clinical trial: So far, no clinical study has been conducted yet.
References:
[1] Tan J, Chen B, He L, Tang Y, Jiang Z, Yin G, Wang J, Jiang X. Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling. Chin J Cancer Rea. 2012 Dec; 24(4): 275–83.
[2] Carvalho A, Annoni R, Torres L, Durao A, Shimada A, Almeida F, Hebeda C, Lopes F, Dolhnikoff F, Martins M, Silva L, Farsky S, Saldiva P, Ulrich C, Owen R, Marcourakis T, Trevisan M, Mauad T. Anacardic acid from Cashew nuts ameliorate lung damage induced by exposure to exhaust particles in mice. Evid-Based Compl Alt. 2013 Jan. DOI: org/10.1155/2013/549879.
- 3,4-O-dimethylcedrusin
Catalog No.:BCN8211
CAS No.:166021-14-3
- Cyclogrifolin
Catalog No.:BCN7547
CAS No.:1660156-04-6
- Z-Thr-OBzl
Catalog No.:BCC2737
CAS No.:16597-50-5
- (-)-Tetramisole
Catalog No.:BCC4670
CAS No.:16595-80-5
- Calystegine A5
Catalog No.:BCN1887
CAS No.:165905-26-0
- Naltrexone
Catalog No.:BCC1783
CAS No.:16590-41-3
- 1-Hydroxy-N-methylacridone
Catalog No.:BCN7551
CAS No.:16584-54-6
- Eperezolid
Catalog No.:BCC5177
CAS No.:165800-04-4
- Linezolid
Catalog No.:BCC2496
CAS No.:165800-03-3
- Torososide A
Catalog No.:BCN4694
CAS No.:165689-32-7
- Methyl 6-acetoxyangolensate
Catalog No.:BCN1732
CAS No.:16566-88-4
- L-Stepholidine
Catalog No.:BCN2599
CAS No.:16562-13-3
- CCT251545
Catalog No.:BCC6487
CAS No.:1661839-45-7
- Bathophenanthroline
Catalog No.:BCC8840
CAS No.:1662-01-7
- Argentinine
Catalog No.:BCN3987
CAS No.:16625-57-3
- Taberdivarine H
Catalog No.:BCN6958
CAS No.:1662688-34-7
- 9-O-Feruloyl-5,5'-dimethoxylariciresinol
Catalog No.:BCN1535
CAS No.:166322-14-1
- m-Nitrohydrocinnamic acid
Catalog No.:BCC9048
CAS No.:1664-57-9
- 1H-Pyrido[3,4-b]indole-1,3 4(2H,9H)-trione
Catalog No.:BCN7913
CAS No.:16641-79-5
- p-Nitrohydrocinnamic acid
Catalog No.:BCC9124
CAS No.:16642-79-8
- trans-4-(Trifluoromethyl)cinnamic acid
Catalog No.:BCN1534
CAS No.:16642-92-5
- Metaxalone
Catalog No.:BCC5223
CAS No.:1665-48-1
- Avasimibe
Catalog No.:BCC2274
CAS No.:166518-60-1
- H-Tyr(Bzl)-OH
Catalog No.:BCC3130
CAS No.:16652-64-5
Spectroscopic studies on the interaction of bovine serum albumin with ginkgolic acid: Binding characteristics and structural analysis
Journal of Luminescence Volume 132, Issue 5, May 2012, Pages 1207–1214
The interaction between Ginkgolic acid C15:0 and bovine serum albumin (BSA) is investigated by several spectroscopic methodologies. At first, the binding characteristics of Ginkgolic acid C15:0 and BSA are determined by fluorescence emission spectra. It is showed that Ginkgolic acid C15:0 quenches the fluorescence of BSA and the static quenching constant KLB is 11.7891×104 L mol−1 s−1 at 297 K. Ginkgolic acid C15:0 and BSA form a 1:1 complex with a binding constant of 9.12×105 L mol−1. Ginkgolic acid C15:0 binds to the Sudlow's drug binding site II in BSA, and the binding distance between them is calculated as 1.63 nm based on the Förster theory. The thermodynamic parameters indicate that the interaction between BSA and Ginkgolic acid C15:0 is driven mainly by hydrophobic forces. On the other hand, structural analysis indicates that Ginkgolic acid C15:0 binding results in an increased hydrophobicity around the tryptophan residues of BSA as revealed by the synchronous fluorescence spectra, and a decrease in α-helix as revealed by the far-UV CD spectra. In addition, ANS, UV–vis and RLS experiments confirmed that Ginkgolic acid C15:0 binding causes a certain structural changes in BSA. These findings provide the binding information between BSA and Ginkgolic acid C15:0), and may be helpful for pharmacokinetics and the design of dosage forms of Ginkgolic acid C15:0.