BathophenanthrolineCAS# 1662-01-7 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 1662-01-7 | SDF | Download SDF |
| PubChem ID | 72812 | Appearance | Powder |
| Formula | C24H16N2 | M.Wt | 332.4 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 6 mg/mL (18.05 mM; Need ultrasonic and warming); | ||
| Chemical Name | 4,7-diphenyl-1,10-phenanthroline | ||
| SMILES | C1=CC=C(C=C1)C2=C3C=CC4=C(C=CN=C4C3=NC=C2)C5=CC=CC=C5 | ||
| Standard InChIKey | DHDHJYNTEFLIHY-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C24H16N2/c1-3-7-17(8-4-1)19-13-15-25-23-21(19)11-12-22-20(14-16-26-24(22)23)18-9-5-2-6-10-18/h1-16H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Bathophenanthroline Dilution Calculator
Bathophenanthroline Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0084 mL | 15.0421 mL | 30.0842 mL | 60.1685 mL | 75.2106 mL |
| 5 mM | 0.6017 mL | 3.0084 mL | 6.0168 mL | 12.0337 mL | 15.0421 mL |
| 10 mM | 0.3008 mL | 1.5042 mL | 3.0084 mL | 6.0168 mL | 7.5211 mL |
| 50 mM | 0.0602 mL | 0.3008 mL | 0.6017 mL | 1.2034 mL | 1.5042 mL |
| 100 mM | 0.0301 mL | 0.1504 mL | 0.3008 mL | 0.6017 mL | 0.7521 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bathophenanthroline is an agent used for the measurement of iron concentrations in aqueous , serum and urine samples by colorimetry.
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Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand.[Pubmed:29443934]
Molecules. 2018 Feb 14;23(2). pii: molecules23020420.
We report on the preparation and thorough characterization of cytotoxic half-sandwich complexes [Ru(eta(6)-pcym)(bphen)(dca)]PF(6) (Ru-dca) and [Os(eta(6)-pcym)(bphen)(dca)]PF(6) (Os-dca) containing dichloroacetate(1-) (dca) as the releasable O-donor ligand bearing its own cytotoxicity; pcym = 1-methyl-4-(propan-2-yl)benzene (p-cymene), bphen = 4,7-diphenyl-1,10-phenanthroline (Bathophenanthroline). Complexes Ru-dca and Os-dca hydrolyzed in the water-containing media, which led to the dca ligand release (supported by (1)H NMR and electrospray ionization mass spectra). Mass spectrometry studies revealed that complexes Ru-dca and Os-dca do not interact covalently with the model proteins cytochrome c and lysozyme. Both complexes exhibited slightly higher in vitro cytotoxicity (IC50 = 3.5 muM for Ru-dca, and 2.6 muM for Os-dca) against the A2780 human ovarian carcinoma cells than cisplatin (IC50 = 5.9 muM), while their toxicity on the healthy human hepatocytes was found to be IC50 = 19.1 muM for Ru-dca and IC50 = 19.7 muM for Os-dca. Despite comparable cytotoxicity of complexes Ru-dca and Os-dca, both the complexes modified the cell cycle, mitochondrial membrane potential, and mitochondrial cytochrome c release by a different way, as revealed by flow cytometry experiments. The obtained results point out the different mechanisms of action between the complexes.
