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3,4-O-dimethylcedrusin

CAS# 166021-14-3

3,4-O-dimethylcedrusin

2D Structure

Catalog No. BCN8211----Order now to get a substantial discount!

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Quality Control of 3,4-O-dimethylcedrusin

3D structure

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3,4-O-dimethylcedrusin

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Chemical Properties of 3,4-O-dimethylcedrusin

Cas No. 166021-14-3 SDF Download SDF
PubChem ID 124426 Appearance Powder
Formula C21H26O6 M.Wt 374.4
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(2S,3R)-2-(3,4-dimethoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol
SMILES COC1=C(C=C(C=C1)C2C(C3=CC(=CC(=C3O2)OC)CCCO)CO)OC
Standard InChIKey UVPCDEDIFJYIPT-OXJNMPFZSA-N
Standard InChI InChI=1S/C21H26O6/c1-24-17-7-6-14(11-18(17)25-2)20-16(12-23)15-9-13(5-4-8-22)10-19(26-3)21(15)27-20/h6-7,9-11,16,20,22-23H,4-5,8,12H2,1-3H3/t16-,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 3,4-O-dimethylcedrusin

The peel of Magnolia officinalis

Biological Activity of 3,4-O-dimethylcedrusin

Description3′,4-O-Dimethylcedrusin can improve wound healing in vivo by stimulating the formation of fibroblasts and collagen.
In vivo

In vivo wound healing activity of Dragon's Blood (Croton spp.), a traditional South American drug, and its constituents[Reference: WebLink]

Phytomedicine, 1995, 2(1):17-22.


METHODS AND RESULTS:
The wound healing activity of dragon'sblood (Croton spp.), in Spanish ‚sangre de drago‛ or ‚sangre de grado‛, a traditional South American drug, and some of its constituents, including the alkaloid taspine (1), the dihydrobenzufuran lignan 3′,4-O-dimethylcedrusin (3,4-O-dimethylcedrusin,2) and proantho-cyanidins, was evaluated in vivo on rats, and compared with the wound healing actitivy of synthetic proanthocyanidins. The beneficial effect of dragon's blood on wound healing was confirmed. Dragon's blood stimulated contraction of the wound, formation of a crust, formation of new collagen, and regeneration of the epithelial layer. 3′,4-O-Dimethylcedrusin also improved wound healing in vivo by stimulating the formation of fibroblasts and collagen, but crude dragon's blood was more effective.
CONCLUSIONS:
This was due to the proanthocyanidins, present in dragon's blood, which stimulate contraction of the wound and precipitate with proteins forming a dark crust covering the wound, but which delay wound repair by a decreased formation of new fibroblasts.

3,4-O-dimethylcedrusin Dilution Calculator

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Preparing Stock Solutions of 3,4-O-dimethylcedrusin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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