GSK256066 2,2,2-trifluoroacetic acidPDE4 inhibitor CAS# 1415560-64-3 |
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Quality Control & MSDS
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| Cas No. | 1415560-64-3 | SDF | Download SDF |
| PubChem ID | 71576691 | Appearance | Powder |
| Formula | C29H27F3N4O7S | M.Wt | 632.61 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 50 mg/mL (79.04 mM; Need ultrasonic) | ||
| Chemical Name | 6-[3-(dimethylcarbamoyl)phenyl]sulfonyl-4-(3-methoxyanilino)-8-methylquinoline-3-carboxamide;2,2,2-trifluoroacetic acid | ||
| SMILES | CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O | ||
| Standard InChIKey | PTTKEASHQDSBJR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C27H26N4O5S.C2HF3O2/c1-16-11-21(37(34,35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4;3-2(4,5)1(6)7/h5-15H,1-4H3,(H2,28,32)(H,29,30);(H,6,7) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
GSK256066 2,2,2-trifluoroacetic acid Dilution Calculator
GSK256066 2,2,2-trifluoroacetic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.5808 mL | 7.9038 mL | 15.8075 mL | 31.6151 mL | 39.5188 mL |
| 5 mM | 0.3162 mL | 1.5808 mL | 3.1615 mL | 6.323 mL | 7.9038 mL |
| 10 mM | 0.1581 mL | 0.7904 mL | 1.5808 mL | 3.1615 mL | 3.9519 mL |
| 50 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.6323 mL | 0.7904 mL |
| 100 mM | 0.0158 mL | 0.079 mL | 0.1581 mL | 0.3162 mL | 0.3952 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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GSK256066(GSK-256066) is an exceptionally high affinity and selective PDE4 inhibitor with an IC50 of 3.2 pM for PDE4B.
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GSK 256066 Trifluoroacetate (GSK256066 2,2,2-trifluoroacetic acid) is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC50 of 3.2 pM for PDE4B; developed for the treatment of chronic obstructive pulmonary disease.
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